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    Acute Coronary Syndromes

    Explore the latest in acute coronary syndromes, including recent guidelines and advances in management of STEMI, NSTEMI, and unstable angina.

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    • Fact or Artifact in Inferior ST Elevation—Avoiding Misdiagnosis and Missed Diagnosis
      JAMA Internal Medicine
      Case Report
      June 5, 2023

      This case report describes a patient in their 60s with a history of hypertension who experienced sudden chest pain radiating to the back and sweating for 2 hours without relief.

      Cardiology Emergency Medicine Percutaneous Coronary Intervention Challenges in Clinical Electrocardiography Ischemic Heart Disease
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Percutaneous Coronary Intervention vs Coronary Artery Bypass Graft Surgery for Left Main Disease in Patients With and Without Acute Coronary Syndromes: A Pooled Analysis of 4 Randomized Clinical Trials
      JAMA Cardiology
      Research
      May 31, 2023

      This pooled analysis includes data from 4 major randomized clinical trials that compare PCI with drug-eluting stents vs CABG to assess differences in outcomes for patients with left main coronary artery disease with and without acute coronary syndrome.

      Cardiology Ischemic Heart Disease Cardiothoracic Surgery Percutaneous Coronary Intervention Surgery
      Full Text | pdf link PDF
    • Association Between Acute Myocardial Infarction and Cognition
      JAMA Neurology
      Research
      May 30, 2023

      This cohort study uses pooled data from 6 US population-based cohort studies to assess whether incident myocardial infarction is associated with changes in cognition immediately after of in the years following the event.

      Dementia and Cognitive Impairment Neurology Ischemic Heart Disease Cardiology
      Full Text | pdf link PDF
    • Myocardial Infarction Bends the Curve of Age-Related Cognitive Decline, but How?
      JAMA Neurology
      Opinion
      May 30, 2023
      Dementia and Cognitive Impairment Neurology Ischemic Heart Disease Cardiology Geriatrics
      Full Text | pdf link PDF
    • Titanium-Nitride-Oxide–Coated vs Everolimus-Eluting Stents in Acute Coronary Syndrome: 5-Year Clinical Outcomes of the TIDES-ACS Randomized Clinical Trial
      JAMA Cardiology
      Research
      May 19, 2023

      This randomized clinical trial compares the rate of main composite outcome of cardiac death, myocardial infarction, or ischemia-driven target lesion revascularization at 5 years in patients with acute coronary syndromes.

      Cardiology Percutaneous Coronary Intervention Ischemic Heart Disease Emergency Medicine
      Full Text | pdf link PDF
    • Sex Differences in Post–Heart Attack Rehospitalizations
      JAMA
      News
      May 17, 2023
      Cardiology Emergency Medicine Ischemic Heart Disease
      Full Text | pdf link PDF free
    • Red Flag on Electrocardiogram Findings in a Patient With Lung Cancer
      JAMA Internal Medicine
      Case Report
      May 8, 2023

      This case report describes a patient in their early 70s with sudden onset squeezing precordial chest pain, back pain, and nausea, and a history of long-term lung cancer treatment.

      Clinical Pharmacy and Pharmacology Emergency Medicine Lung Cancer Targeted and Immune Cancer Therapy Oncology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Association of Cardiac Biomarkers With Major Adverse Cardiovascular Events in High-risk Patients With Diabetes: A Secondary Analysis of the DECLARE-TIMI 58 Trial
      JAMA Cardiology
      Research
      May 1, 2023

      This secondary analysis of the DECLARE-TIMI 58 trial evaluates whether N-terminal pro–B-type natriuretic peptide and high-sensitivity cardiac troponin T levels can identify a subset of patients with type 2 diabetes at higher risk and who might benefit more from dapagliflozin with regard to atherosclerotic events.

      Diabetes Ischemic Heart Disease Diabetes and Endocrinology Cardiology
      Full Text | pdf link PDF
    • Effect of Routine Invasive vs Conservative Strategy in Older Adults With Frailty and Non–ST-Segment Elevation Acute Myocardial Infarction: A Randomized Clinical Trial
      JAMA Internal Medicine
      Research
      May 1, 2023

      This randomized clinical trial compares outcomes of invasive vs conservative strategies in older adults with frailty and non–ST-segment elevation acute myocardial infarction at 1 year.

      Geriatrics Cardiology Ischemic Heart Disease Emergency Medicine
      Full Text | pdf link PDF
    • Assessing the Clinical Treatment Dynamics of Antiplatelet Therapy Following Acute Coronary Syndrome and Percutaneous Coronary Intervention in the US
      JAMA Network Open
      Research
      April 17, 2023

      This cohort study uses national claims data to describe platelet ADP P2Y12 receptor inhibitor choice and switching among patients who underwent percutaneous coronary intervention for acute coronary syndrome.

      Cardiology Clinical Pharmacy and Pharmacology Pharmacy and Clinical Pharmacology Percutaneous Coronary Intervention Bleeding and Transfusion
      Full Text | pdf link PDF open access
    • Aspirin vs Clopidogrel for Long-term Maintenance After Coronary Stenting in Patients With Diabetes: A Post Hoc Analysis of the HOST-EXAM Trial
      JAMA Cardiology
      Research
      April 12, 2023

      This secondary analysis of the HOST-EXAM randomized clinical trial evaluates clopidogrel vs aspirin for long-term maintenance after percutaneous coronary intervention in patients with diabetes.

      Diabetes Diabetes and Endocrinology Ischemic Heart Disease Cardiology Percutaneous Coronary Intervention
      Full Text | pdf link PDF
    • Cardiovascular Outcomes and Mortality After Bariatric Surgery in Patients With Nonalcoholic Fatty Liver Disease and Obesity
      JAMA Network Open
      Research
      April 7, 2023

      This cohort study assesses the association of bariatric surgery with the incidence of adverse cardiovascular events and all-cause mortality in patients with nonalcoholic fatty liver disease (NAFLD) and obesity.

      Gastroenterology and Hepatology Hepatobiliary Disease Cardiovascular Risk Factors Obesity Cardiology
      Full Text | pdf link PDF open access
    • Prevalence of Antiphospholipid Antibodies and Association With Incident Cardiovascular Events
      JAMA Network Open
      Research
      April 4, 2023

      This cohort study examines the association between measurements of antiphospholipid antibodies (aPL) at a single time point and atherosclerotic cardiovascular disease risk in a diverse population.

      Cardiology Cardiovascular Risk Factors Dyslipidemia Neurology Stroke
      Full Text | pdf link PDF open access
    • Differences in Treatment Patterns and Outcomes of Acute Myocardial Infarction for Low- and High-Income Patients in 6 Countries
      JAMA
      Research
      April 4, 2023

      This serial cross-sectional cohort study compares whether treatment patterns and outcomes for patients presenting with acute myocardial infarction differ for low- vs high-income individuals across 6 countries.

      Cardiology Emergency Medicine Global Health Ischemic Heart Disease Percutaneous Coronary Intervention
      Full Text | pdf link PDF has multimedia
    • Performance of the European Society of Cardiology 0/1-Hour Algorithm With High-Sensitivity Cardiac Troponin T Among Patients With Known Coronary Artery Disease
      JAMA Cardiology
      Research
      April 1, 2023

      This diagnostic study evaluates and compares the diagnostic performance of the European Society of Cardiology (ESC) 0/1-hour algorithm for 30-day cardiac death or myocardial infarction among patients with and without known coronary artery disease and determine if the algorithm could achieve the negative predictive value rule-out threshold of 99% or higher.

      Ischemic Heart Disease Cardiology Emergency Medicine
      Full Text | pdf link PDF
    • Critical Appraisal of the Negative Predictive Performance of the European Society of Cardiology 0/1-Hour Algorithm for Evaluating Patients With Chest Pain in the US
      JAMA Cardiology
      Opinion
      April 1, 2023
      Cardiology Emergency Medicine Ischemic Heart Disease
      Full Text | pdf link PDF
    • Uncommon Culprit Vessel of de Winter Electrocardiogram Pattern
      JAMA Internal Medicine
      Case Report
      April 1, 2023

      This case report describes a patient in their 50s who presented to the emergency department with perspiration, persistent and squeezing chest pain, and chest distress that had persisted for 90 minutes without relief.

      Cardiology Challenges in Clinical Electrocardiography Ischemic Heart Disease Emergency Medicine
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Wide QRS Complex Transient Pattern in a Patient With Severe COVID-19
      JAMA Internal Medicine
      Case Report
      April 1, 2023

      This case report describes a patient in their 60s with shortness of breath who tested positive for COVID-19.

      Emergency Medicine Challenges in Clinical Electrocardiography Ischemic Heart Disease Coronavirus (COVID-19) Cardiology
      Full Text | pdf link PDF | CME & MOC free is active quiz
    • A Paradoxical ST-Segment Elevation Distribution Rendering a Challenging Prediction of the Culprit Vessel in Acute Myocardial Infarction
      JAMA Internal Medicine
      Case Report
      March 1, 2023

      This case report describes a patient in their 50s with sudden-onset chest pain.

      Cardiology Challenges in Clinical Electrocardiography Emergency Medicine Ischemic Heart Disease
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Association of Sociodemographic Characteristics With 1-Year Hospital Readmission Among Adults Aged 18 to 55 Years With Acute Myocardial Infarction
      JAMA Network Open
      Research
      February 14, 2023

      This cohort study of patients with acute myocardial infarction (AMI) assesses whether race and social determinants of health are associated with hospital readmission rates within 1 year of discharge.

      Equity, Diversity, and Inclusion Cardiology Emergency Medicine Health Care Quality Ischemic Heart Disease
      Full Text | pdf link PDF open access
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