Explore the latest in amyotrophic lateral sclerosis, including recent advances in understanding the epidemiology and etiology of the disorder.
This case-control study investigates cerebrospinal fluid levels of neurofilament light protein in participants with various forms of dementia, motor neuron disease, and movement disorders and controls, as determined by clinical and autopsy-definite criteria.
This human and animal study assesses the role of regulatory T-cells in the pathophysiology of amyotrophic lateral sclerosis and the therapeutic association with increasing regulatory T-cell activity in a mouse model of the disease.
This case-control cohort study investigates the association between the onset and prognosis of amyotrophic lateral sclerosis and serum retinol-binding protein 4 concentration as a biomarker for insulin resistance and vitamin A metabolism.
This Medical News story discusses recent progress in ALS research fueled by work in basic model systems and funding from the Ice Bucket Challenge.
This multicenter cross-sectional study assesses the occurrence of cognitive, structural, and microstructural changes in presymptomatic carriers of C9orf72 mutation.
This study investigates the rate of decline in percentage predicted slow vital capacity and its association with respiratory-related clinical events and mortality in patients with amyotrophic lateral sclerosis.
This Art and Medicine essay reviews the 2 best graphic medicine novels of 2017: Last Things by Marissa Moss, about her husband’s decline from ALS; and Taking Turns by MK Czerwiec, about a Chicago inpatient AIDS unit.
This longitudinal cohort study assesses peripheral inflammatory markers, tracks immune changes, and correlates these changes with disease progression in patients with amyotrophic lateral sclerosis.
This population-based, case-control, family aggregation study examines the frequency and range of neuropsychiatric conditions that occur within individual first-degree and second-degree relatives of patients with amyotrophic lateral sclerosis.
This epidemiologic register-based study examines the 20-year epidemiologic trends of amyotrophic lateral sclerosis in the Piemonte and Valle d’Aosta regions of Italy.
This study characterizes the transcriptomics of peripheral monocytes in patients with amyotrophic lateral sclerosis.
This cohort study examines the prognostic significance of C-reactive protein in amyotrophic lateral sclerosis.
This study assesses the ability of neurofilament light chain to serve as a diagnostic biomarker in amyotrophic lateral sclerosis and the prognostic value of cerebrospinal fluid neurofilament light chain in patients with amyotrophic lateral sclerosis.
This cohort study examines evidence for disease anticipation in families carrying a C9orf72 repeat expansion by analyzing age at onset, disease duration, and age at death in successive generations.
This review discusses the pathogenicity of variants that affect protein levels of TBK1, the gene associated with amyotrophic lateral sclerosis and frontotemporal dementia.
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