[Skip to Navigation]
Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue
JAMA Network Home
JAMA Network
HomeJN Learning / CMESubscribeJobs

Multimedia

Podcasts Video

Publications

JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959)
JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions
Terms of Use | Privacy Policy | Accessibility Statement
2023 American Medical Association. All Rights Reserved
    Sign In
    Individual Sign In
    Sign inCreate an Account
    Access through your institution
    Sign In
    Purchase Options:
    Subscriptions and More

    Amyotrophic Lateral Sclerosis

    Explore the latest in amyotrophic lateral sclerosis, including recent advances in understanding the epidemiology and etiology of the disorder.

    Add to My Interests
     
    Publication
    All Publications
    Apply
    Publication
    Article Type
    All Article Types
    Apply
    Article Type
    • What Is Amyotrophic Lateral Sclerosis?
      JAMA
      Patient Information
      December 27, 2022

      This JAMA Patient Page describes the neurological disorder amyotrophic lateral sclerosis and its symptoms, risk factors, diagnosis, and treatment options.

      Neurology Neuromuscular Diseases Patient Information JAMA Patient Information
      Full Text | pdf link PDF free
    • Preapproval Promises to Voluntarily Withdraw FDA-Approved Drugs
      JAMA
      Opinion
      December 27, 2022

      This Viewpoint provides recommendations for improvements to strengthen legal obligations and decrease ambiguity for the US Food and Drug Administration regarding their reliance on voluntary preapproval withdrawal pledges.

      Law and Medicine Neurology Regulatory Agencies Health Policy Drug Development
      Full Text | pdf link PDF
    • Amyotrophic Lateral Sclerosis Clinical Trials and Interpretation of Functional End Points and Fluid Biomarkers: A Review
      JAMA Neurology
      Review
      December 1, 2022

      This narrative review discusses aspects of clinical trial design that may be important in discerning efficacy of treatments for amyotrophic lateral sclerosis (ALS).

      Neurology Neuromuscular Diseases
      Full Text | pdf link PDF | CME & MOC is active quiz
    • New Funding for Research Into Rare Diseases Treatments
      JAMA
      News
      November 15, 2022
      Neurology Drug Development Regulatory Agencies Neuromuscular Diseases
      Full Text | pdf link PDF
    • New Research Partnership for ALS, Rare Neurodegenerative Diseases
      JAMA
      News
      November 1, 2022
      Neurology Drug Development Neuromuscular Diseases
      Full Text | pdf link PDF
    • Partnership Focuses on Neurodegenerative Diseases
      JAMA
      News
      October 18, 2022
      Neurology
      Full Text | pdf link PDF
    • Trial Tests Combined Cell and Gene Therapy for ALS
      JAMA
      News
      October 11, 2022
      Neurogenetics Neurology Neuromuscular Diseases Genetics and Genomics
      Full Text | pdf link PDF
    • Action Plan Targets ALS and Other Neurodegenerative Diseases
      JAMA
      News
      August 2, 2022
      Neurology Neuromuscular Diseases Regulatory Agencies
      Full Text | pdf link PDF
    • TDP-43 Accumulation Within Intramuscular Nerve Bundles of Patients With Amyotrophic Lateral Sclerosis
      JAMA Neurology
      Research
      July 1, 2022

      This dual case-control and cohort study assesses for a characteristic pathological hallmark in the muscle tissues of patients with amyotrophic lateral sclerosis.

      Neurology Neuromuscular Diseases Clinical Pharmacy and Pharmacology
      Full Text | pdf link PDF open access
    • Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial
      JAMA Neurology
      Research
      June 1, 2022

      This randomized clinical trial showed that use of ultrahigh-dose methylcobalamin in Japanese patients in the early stages of amyotrophic lateral sclerosis with moderate progression can slow functional decline and had a good safety profile.

      Neurology Neuromuscular Diseases
      Full Text | pdf link PDF
    • Unintended Consequences of Approving Unproven Treatments—Hope, Hype, or Harm?
      JAMA Neurology
      Opinion
      February 1, 2022
      Neurology Neuromuscular Diseases
      Full Text | pdf link PDF
    • Fasciculation
      JAMA
      Humanities
      February 1, 2022
      Neurology Neuromuscular Diseases Poetry Poetry and Medicine
      Full Text | pdf link PDF
    • Safety and Effectiveness of Long-term Intravenous Administration of Edaravone for Treatment of Patients With Amyotrophic Lateral Sclerosis
      JAMA Neurology
      Research
      February 1, 2022

      This multicenter cohort study uses real-world clinical data to compare the long-term safety and effectiveness of intravenous edaravone plus riluzole therapy vs propensity score–matched controls receiving riluzole therapy alone among patients with amyotrophic lateral sclerosis.

      Neurology Neuromuscular Diseases
      Full Text | pdf link PDF free
    • Incidence of and Mortality From Amyotrophic Lateral Sclerosis in National Football League Athletes
      JAMA Network Open
      Research
      December 15, 2021

      This cohort study evaluates the incidence of and mortality from amyotrophic lateral sclerosis (ALS) in National Football League (NFL) athletes from 1960 to 2019 and describes characteristics associated with ALS within this cohort.

      Neurology Sports Medicine Neuromuscular Diseases
      Full Text | pdf link PDF open access
    • Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Sclerosis
      JAMA Neurology
      Research
      October 1, 2021

      This genetic association study identifies genetic variants associated with juvenile amyotrophic lateral sclerosis.

      Genetics and Genomics Neurology Neuromuscular Diseases
      Full Text | pdf link PDF open access
    • Respiratory Care for Patients With Amyotrophic Lateral Sclerosis in the US: In Need of Support
      JAMA Neurology
      Opinion
      September 1, 2021

      This Viewpoint describes the dearth of noninvasive ventilation for patients with amyotrophic lateral sclerosis in the US and proposes methods to increase access to this type of care.

      Neurology Neuromuscular Diseases Respiratory Failure and Ventilation Critical Care Medicine
      Full Text | pdf link PDF
    • Sailing to the Mediterranean and Navigating Amyotrophic Lateral Sclerosis
      JAMA Neurology
      Opinion
      August 1, 2021

      This essay discusses the journey of a surgical oncologist as she navigates her father’s diagnosis of amyotrophic lateral sclerosis as a physician and daughter in the face of evolving health care value.

      Humanities Narrative Medicine Neurology On The Brain
      Full Text | pdf link PDF
    • Effect of Ezogabine on Cortical and Spinal Motor Neuron Excitability in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial
      JAMA Neurology
      Research
      February 1, 2021

      This randomized clinical trial examines the use of clinical neurophysiological metrics of excitability as pharmacodynamic biomarkers in individuals with amyotrophic lateral sclerosis.

      Neurology Neuromuscular Diseases
      Full Text | pdf link PDF free
    • Assessment of Use and Safety of Edaravone for Amyotrophic Lateral Sclerosis in the Veterans Affairs Health Care System
      JAMA Network Open
      Research
      October 5, 2020

      This cohort study uses real-world data to assess patient characteristics and use as well as the safety and effectiveness of edaravone among patients with amyotrophic lateral sclerosis in the US Department of Veterans Affairs Health Care System.

      Neurology Neuromuscular Diseases Health Care Quality Veterans Health
      Full Text | pdf link PDF open access
    • In Familial ALS, Antisense Agent Reduces Disease-Related Proteins
      JAMA
      News
      August 11, 2020
      Neurology Neuromuscular Diseases
      Full Text | pdf link PDF
    1 2 3 4 5 … 11
    Next 20 Results »
    Get the latest from JAMA Network
    Sign Up
    Privacy Policy | Terms of Use
     

    Select Your Interests

    Customize your JAMA Network experience by selecting one or more topics from the list below.

    • Academic Medicine
    • Acid Base, Electrolytes, Fluids
    • Allergy and Clinical Immunology
    • Anesthesiology
    • Anticoagulation
    • Art and Images in Psychiatry
    • Bleeding and Transfusion
    • Cardiology
    • Caring for the Critically Ill Patient
    • Challenges in Clinical Electrocardiography
    • Clinical Challenge
    • Clinical Decision Support
    • Clinical Implications of Basic Neuroscience
    • Clinical Pharmacy and Pharmacology
    • Complementary and Alternative Medicine
    • Consensus Statements
    • Coronavirus (COVID-19)
    • Critical Care Medicine
    • Cultural Competency
    • Dental Medicine
    • Dermatology
    • Diabetes and Endocrinology
    • Diagnostic Test Interpretation
    • Drug Development
    • Electronic Health Records
    • Emergency Medicine
    • End of Life
    • Environmental Health
    • Equity, Diversity, and Inclusion
    • Ethics
    • Facial Plastic Surgery
    • Gastroenterology and Hepatology
    • Genetics and Genomics
    • Genomics and Precision Health
    • Geriatrics
    • Global Health
    • Guide to Statistics and Methods
    • Guidelines
    • Hair Disorders
    • Health Care Delivery Models
    • Health Care Economics, Insurance, Payment
    • Health Care Quality
    • Health Care Reform
    • Health Care Safety
    • Health Care Workforce
    • Health Disparities
    • Health Inequities
    • Health Informatics
    • Health Policy
    • Hematology
    • History of Medicine
    • Humanities
    • Hypertension
    • Images in Neurology
    • Implementation Science
    • Infectious Diseases
    • Innovations in Health Care Delivery
    • JAMA Infographic
    • Law and Medicine
    • Leading Change
    • Less is More
    • LGBTQIA Medicine
    • Lifestyle Behaviors
    • Medical Coding
    • Medical Devices and Equipment
    • Medical Education
    • Medical Education and Training
    • Medical Journals and Publishing
    • Melanoma
    • Mobile Health and Telemedicine
    • Narrative Medicine
    • Nephrology
    • Neurology
    • Neuroscience and Psychiatry
    • Notable Notes
    • Nursing
    • Nutrition
    • Nutrition, Obesity, Exercise
    • Obesity
    • Obstetrics and Gynecology
    • Occupational Health
    • Oncology
    • Ophthalmic Images
    • Ophthalmology
    • Orthopedics
    • Otolaryngology
    • Pain Medicine
    • Pathology and Laboratory Medicine
    • Patient Care
    • Patient Information
    • Pediatrics
    • Performance Improvement
    • Performance Measures
    • Perioperative Care and Consultation
    • Pharmacoeconomics
    • Pharmacoepidemiology
    • Pharmacogenetics
    • Pharmacy and Clinical Pharmacology
    • Physical Medicine and Rehabilitation
    • Physical Therapy
    • Physician Leadership
    • Poetry
    • Population Health
    • Preventive Medicine
    • Professional Well-being
    • Professionalism
    • Psychiatry and Behavioral Health
    • Public Health
    • Pulmonary Medicine
    • Radiology
    • Regulatory Agencies
    • Research, Methods, Statistics
    • Resuscitation
    • Rheumatology
    • Risk Management
    • Scientific Discovery and the Future of Medicine
    • Shared Decision Making and Communication
    • Sleep Medicine
    • Sports Medicine
    • Stem Cell Transplantation
    • Substance Use and Addiction Medicine
    • Surgery
    • Surgical Innovation
    • Surgical Pearls
    • Teachable Moment
    • Technology and Finance
    • The Art of JAMA
    • The Arts and Medicine
    • The Rational Clinical Examination
    • Tobacco and e-Cigarettes
    • Toxicology
    • Trauma and Injury
    • Treatment Adherence
    • Ultrasonography
    • Urology
    • Users' Guide to the Medical Literature
    • Vaccination
    • Venous Thromboembolism
    • Veterans Health
    • Violence
    • Women's Health
    • Workflow and Process
    • Wound Care, Infection, Healing
    Save Preferences
    Privacy Policy | Terms of Use
    X

    JAMA Network

    Content

    Home Podcasts Video Featured Content
    JN Learning / CME Store Jobs Institutions Reprints & Permissions

    Subscribe

    Go

    JAMA Network

    Publications

    JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959)

    Sites

    Art and Images in Psychiatry Best of the JAMA Network Clinical Crosswords from JAMA Coronavirus Resource Center Evidence-Based Medicine: An Oral History Fishbein Fellowship Genomics and Precision Health Hypertension JAMA Forum Archive JAMA Network Audio JAMA Network Video JAMA Network Conferences JAMA Surgery Guide to Statistics and Methods Machine Learning Medical News Mpox (Monkeypox) Research Ethics Topics and Collections Visual Abstracts War and Health

    Featured Articles

    Antiretroviral Drugs for HIV Treatment and Prevention in Adults - 2022 IAS-USA Recommendations CONSERVE 2021 Guidelines for Reporting Trials Modified for the COVID-19 Pandemic Global Burden of Cancer, 2010-2019 Global Burden of Long COVID Global Burden of Skin Diseases, 1990-2017 Guidelines for Reporting Outcomes in Trial Protocols: The SPIRIT-Outcomes 2022 Extension Mass Violence and the Complex Spectrum of Mental Illness and Mental Functioning Organization and Performance of US Health Systems Spirituality in Serious Illness and Health The US Medicaid Program: Coverage, Financing, Reforms, and Implications for Health Equity

    USPSTF Recommendation Statements

    Screening for Colorectal Cancer Screening for Hypertension Screening for Lung Cancer Screening for Prediabetes and Type 2 Diabetes Statins for Primary Prevention of Cardiovascular Disease Vitamin and Mineral Supplements for Primary Prevention of of Cardiovascular Disease and Cancer

    Blogs

    AMA Style Insider

    Information

    For Authors For Institutions & Librarians For Advertisers For Subscription Agents For Employers & Job Seekers For the Media Equity, Diversity, Inclusion Online Commenting Policy Public Access and Open Access Policy Statement on Potentially Offensive Content

    JAMA Network Products

    AMA Manual of Style JAMAevidence Peer Review Congress

    JN Learning

    Home State CME Clinical Challenge CME Atrial Fibrillation Course Women's Health Course CME / MOC Reporting Preferences About CME & MOC

    Help

    Subscriptions & Renewals Manage Emails Update My Address Contact Us My Account

    JAMA Career Center

    Physician Job Listings
     
    Get the latest from JAMA Network
    Sign Up
    Privacy Policy | Terms of Use
    Jama Network Logo

    © 2023 American Medical Association. All Rights Reserved.
    Terms of Use| Privacy Policy| Accessibility Statement

    Silverchair Logo
    .
    ×
    Access your subscriptions

    Add or change institution
    Free access to newly published articles

    To register for email alerts with links to free full-text articles
    Purchase access

    Get full journal access for 1 year
    Get unlimited access and a printable PDF ($40.00)—
    Sign in or create a free account
    Access your subscriptions

    Add or change institution
    Free access to newly published articles

    To register for email alerts with links to free full-text articles
    Purchase access

    Get full journal access for 1 year
    Get unlimited access and a printable PDF ($40.00)—
    Sign in or create a free account
    Sign in to access free PDF

    Add or change institution
    Free access to newly published articles

    To register for email alerts with links to free full-text articles
    Save your search

    Free access to newly published articles

    To register for email alerts with links to free full-text articles
    Purchase access

    Customize your interests

    Free access to newly published articles

    To register for email alerts with links to free full-text articles
    Create a personal account or sign in to:
    • Register for email alerts with links to free full-text articles
    • Access PDFs of free articles
    • Manage your interests
    • Save searches and receive search alerts
    Privacy Policy
    Make a comment

    Free access to newly published articles

    To register for email alerts with links to free full-text articles
    Create a personal account or sign in to:
    • Register for email alerts with links to free full-text articles
    • Access PDFs of free articles
    • Manage your interests
    • Save searches and receive search alerts
    Privacy Policy