Explore the latest in bipolar and related disorders, including recent advances in management of manic depression in children and adults.
This cross-sectional, longitudinal study examines neuroimaging measures of emotion processing and regulation neural circuitries with symptoms of bipolar disorder in offspring of parents with bipolar disorder compared with offspring of parents with non–bipolar disroder psychopathologies and offspring of healthy parents.
This study uses normative modeling to map regional brain alterations to examine brain structural heterogeneity in adults with schizophrenia and bipolar disorder vs healthy individuals.
This population-based cohort study characterizes neurocognitive functions in 7-year-old children at familial high risk of schizophrenia and bipolar disorder in the Danish High Risk and Resilience Study VIA 7.
This Finnish nationwide cohort study examines the comparative effectiveness of pharmacologic treatments in the prevention of rehospitalization in a nationwide cohort of patients with bipolar disorder.
This Viewpoint argues that the therapeutic approach to bipolar disorder should mimic that for cancer, with immediate aggressive treatment and vigilant monitoring and follow-up to prevent long-term sequelae of disability, cognitive deficits, and suicide.
This randomized clinical trial evaluates the efficacy and safety of transcranial direct current stimulation as add-on therapy in patients with bipolar depression.
This case-control study examines the association between polygenic liability for schizophrenia and psychotic presentations of bipolar disorder.
This study uses data from the population-based Generation R Study of Rotterdam, the Netherlands, to assess an association of genetic risk for schizophrenia and bipolar disorder with infant neuromotor development.
This genome-wide association study tests whether a polygenic score for schizophrenia is associated with treatment response to lithium in bipolar affective disorder and explores the potential molecular underpinnings of this association.
This Viewpoint discusses a neurocomputational model of bipolar disorder and makes predictions about how mood changes will escalate, resolve, and reverse in bipolar disorder.
This Arts and Medicine essay uses Kay Redfield Jamison’s 2016 study of poet Robert Lowell to explore writing as a way of calming disintegrated psyches and proposes that physicians collaborate with patients who have bipolar illness to balance the effects medications have on blunting manic symptoms and creative impulses.
This Viewpoint summarizes a number of important issues related to the clinical use of ketamine for the treatment of psychiatric disorders addressed in the consensus statement and provides suggestions for addressing remaining concerns.
This longitudinal cohort study assesses a risk calculator to predict the 5-year onset of bipolar spectrum disorder in youth at familial risk for the disorder.
This longitudinal nationwide cohort study determines the association of the adolescent personality domains of social maturity, mental energy, and emotional stability with later diagnosis of serious mental illness among Swedish men.
This case-control study examines whether the general cognitive deficit observed across psychotic disorders is similarly associated with functional integrity of 2 brain networks widely implicated in supporting many cognitive domains.
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: