Explore the latest in stem cell transplantation, including recent advances in indications for the procedure, safer conditioning regimens, and more.
This cohort study analyzes infants who received allogeneic hematopoietic cell transplants at age 12 months or younger to determine changes over time in complications and outcomes.
This consensus project reports the findings of the American Society for Blood and Marrow Transplantation, Center for International Blood and Marrow Transplant Research, and European Society for Blood and Marrow Transplantation expert panel, which convened to formulate consensus recommendations regarding the use of maintenance and/or consolidation therapies after autologous hematopoietic cell transplantation in patients with lymphoma.
This cohort study examines patient data in the European Society for Blood and Marrow Transplantation Registry for causes of death, risk factors, and overall survival rates among patients who received a second cancer diagnosis after being treated with stem cell transplant.
This nonrandomized controlled intervention study compared the effect of matched sibling donor hematopoietic stem cell transplantation (HSCT) vs standard care comprising transfusions and hydroxyurea on transcranial Doppler velocities, a measure of cerebral vasculopathy, at 1 year in children with sickle cell anemia requiring chronic transfusion.
In this randomized trial, nonmyeloablative hematopoietic stem cell transplantation (HSCT) resulted in longer time to disease progression among patients with relapsing-remitting multiple sclerosis compared with continued disease-modifying therapy.
This cohort study examines cause-specific late mortality among individuals who have lived 2 years or more after allogeneic blood or marrow transplantation performed in childhood and whether rates of late mortality have changed over time.
This case report describes alopecia universalis and chronic graft-vs-host disease occurring after allogenic hematopoietic stem-cell transplantation and treated with ruxolitinib.
This Medical News & Perspectives article examines the proliferation of US clinics offering unproven stem cell therapies.
This open-label randomized clinical trial involving pediatric patients with acute leukemia receiving intensive chemotherapy or undergoing hematopoietic stem cell transplantation compares the rate of bacteremia among those who received levofloxacin prophylaxis with those who did not.
This registry-based study compares survival in patients with acute myelogenous leukemia who have undergone a second allogeneic hematopoietic cell transplant vs donor lymphocyte infusion after relapse.
This case series examines the factors that contribute to disease progression and neurological deterioration in children who undergo hematopoietic stem cell transplantation to treat cerebral X-linked adrenoleukodystrophy.
This case series describes the occurrence of graft-vs-host-disease (GVHD) in patients with cutaneous T-cell lymphomas (CTCLs) treated with the CC chemokine receptor 4 (CCR4) antibody mogalizumab prior to allogeneic hematopoietic stem cell transplantation (HSCT).
This study examines crowdfunding campaigns on GoFundMe and YouCaring sponsored by US-based businesses engaging in direct-to-consumer marketing of stem cell interventions to discover whether the benefits and risks are mentioned in the campaign descriptions.
This systematic review and meta-analysis reviews phase 3 randomized clinical trials of high-dose therapy followed by autologous stem cell transplant in patients with multiple myeloma.
This cohort study examines the prognostic association of comorbidities on 1-year mortality after initial therapy of acute myeloid leukemia and a risk-stratifying composite model that incorporates comorbidities, age, and cytogenetic/molecular risks.
A 66-year-old man developed noninfectious fever and rash after autologous HSCT. Chest computed tomography showed ground-glass and consolidative lung opacities; skin punch biopsy showed vacuolar change and superficial perivascular mononuclear cell infiltrate. What would you do next?
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