Explore the latest in valvular heart disease, including advances in diagnosis and management of mitral and aortic valve disease, TAVR, and more.
A 40-year-old woman with dizziness and imbalance, a petechial rash on her palms and soles, and a right thumbnail splinter hemorrhage had acute right cerebellar infarcts with a left atrial mass on CT angiogram. What is the diagnosis and what would you do next?
This case report describes a patient with severe biventricular dilatation and functional mitral and tricuspid regurgitation.
A 40-year-old woman with a history of vitral valve endocarditis is pregnant and presents with mild exertional dyspnea, a right ventricular heave, and elevated jugular venous pulsation. What would you do next?
This cohort study assesses whether left ventricular volumes and volume-derived left ventricular ejection fraction are determinants of mortality in aortic regurgitation.
A woman presents with jugular venous pulsations, a grade 3/6 systolic murmur, and a mobile mass located on the tricuspid valve. What would you do next?
This cohort study assesses contemporary outcomes of mitral valve-in-valve replacement with the SAPIEN 3 transcatheter heart valve.
This randomized clinical study assesses whether a 6-month mobile cardiac rehabilitation program is an effective therapy for elderly patients who decline participation in cardiac rehabilitation.
This Viewpoint discusses the national coverage decision for the MitraClip in patients with functional mitral regurgitation.
This case report describes pseudopapilledema with exuberant epipapillary fibrosis in both eyes of a man with Williams syndrome.
This study evaluates the procedural safety, efficacy, and 30-day outcomes of transcatheter aortic valve replacement in patients with bicuspid aortic stenosis at low surgical risk.
This diagnostic study aims to (1) determine if clonal hematopoiesis of indeterminate potential is associated with an inflammatory gene expression that sensitizes monocytes to aggravated immune responses and (2) generate hypotheses on the relevance of this to coronavirus disease 2019 infection and cytokine release syndrome.
This case report describes eccentric mitral regurgitation, stenosis, and poorly visualized posterior mitral leaflet in an elderly woman.
This cross-sectional study assesses national 30-day and 1-year outcomes of mitral valve surgery and defines the hospital- and surgeon-level volume-outcome associations for mitral valve repair or replacement in patients with primary mitral regurgitation.
This systematic review and meta-analysis examines the natural history of asymptomatic aortic stenosis and the association of early intervention with survival.
This cohort study evaluates the associations of elevated B-type natriuretic peptide levels after transcatheter aortic valve replacement (TAVR) and change in B-type natriuretic peptide levels between follow-up time points with risk of subsequent clinical outcomes.
This Viewpoint describes the diverse pathophysiology of mitral regurgitation and discusses implications for clinical care and trial results interpretation.
This prespecified analysis of a randomized clinical trial assesses the long-term health status of surviving patients randomized to self-expanding transcatheter or surgical aortic valve replacement.
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