Explore the latest in coagulation disorders, including primary and secondary coagulopathies, hemophilia and factor deficiencies, and more.
The case report describes the occurrence of antiphospholipid syndrome following pembrolizumab treatment of stage IIIB unresectable melanoma.
This cohort study investigates the association between heparin-induced thrombocytopenia and bacterial infection in trauma patients.
This cohort study uses Swedish national databases to assess major bleeding and venous thromboembolism (VTE) following hip and knee replacement surgical procedures in patients with and without a family history of VTE.
This report describes a woman diagnosed with a rare case of concomitant heparin-induced thrombocytopenia and antiphospholipid antibody syndrome that presented with auricular necrosis.
This phase 3 randomized clinical trial compares the efficacy and safety of Janus kinase 2 inhibitor pacritinib with that of best available therapy, including ruxolitinib, in patients with myelofibrosis and thrombocytopenia.
This Teachable Moment describes the case of a 56-year-old man who presented to his primary care physician with bleeding gums and was subsequently diagnosed with primary immune thrombocytopenia.
A 45-year-old man with superior mesenteric vein thrombosis (SMVT) and with mesenteric ischemia was treated with partial small bowel resection and 2 weeks of enoxaparin. Three weeks later, he underwent bowel resection for recurrent SMVT and developed venous thromboembolism on intravenous heparin. Lab results were consistent with heparin-induced thrombocytopenia (4Ts score, 6). What would you do next?
This case-control study compares the hypercoagulability status of patients with calciphylaxis and renal disease with controls to identify conditions that are risk factors for developing calciphylaxis while controlling for chronic kidney disease.
A 39-year-old man with a history of ischemic stroke presented with right calf swelling and shortness of breath and was diagnosed with pulmonary embolism by CTPA. Testing 2 days later showed elevated titers of anticardiolipin and anti–β2 glycoprotein I antibodies and negative lupus anticoagulant screening assays. How would you interpret these results?
An 84-year-old woman with a history of chronic kidney disease, prior stroke, and hypertension but no personal or family history of bleeding disorders was admitted with a 2-week history of spontaneous subcutaneous ecchymoses and hematomas. She had normal vital signs, laboratory results showing isolated severe anemia but unremarkable for other causes of anemia, and a large soft-tissue hematoma in the left chest wall without evidence of internal hemorrhage. How do you interpret these test results?
This cohort study investigates whether a low serum calcium level is associated with an increase in the extent of bleeding in patients with intracerebral hemorrhage as measured by baseline hematoma volume and risk of hematoma expansion.
This case report describes a male infant born with an unusual, large vascular mass complicated by anemia, thrombocytopenia, and disseminated intravascular coagulopathy, as well as innumerable small vascular papules in a generalized cutaneous distribution.
A 22-year-old woman presented with a 2-month history of fevers and pleuritic chest pain and a 2-day history of cutaneous necroses on her ears, without trauma. Evaluation revealed abnormal coagulation values and a deep vein thrombosis in one leg. What would you do next?
This cohort study determines whether dysfunctional valve prostheses are associated with von Willebrand factor abnormalities, identifies their severity relative to other conditions, and describes associated bleeding and the occurrence of gastrointestinal angiodysplasia.
This Teachable Moment explains that increased awareness of type II thrombocytopenia has been associated with overtesting and inappropriate treatment and calls for more discriminate testing based on the well-validated 4T score.
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