Explore the latest in coagulation disorders, including primary and secondary coagulopathies, hemophilia and factor deficiencies, and more.
A 5-year-old boy with a history of Escherichia coli infection complicated by hemolytic uremic syndrome presents with a homogenous, gray mass in the macula of the right eye. What would you do next?
This randomized trial compares the effect of recombinant human soluble thrombomodulin vs placebo in patients with sepsis-associated coagulopathy on 28-day all-cause mortality.
This cohort study examines the use of closure time following stimulation with collagen and adenosine diphosphate vs the platelet count as a marker of bleeding in premature neonates with thrombocytopenia.
A 30-year-old previously healthy man presented with 1 month of rapidly declining vision in both eyes following acute gastroenteritis.
The case report describes the occurrence of antiphospholipid syndrome following pembrolizumab treatment of stage IIIB unresectable melanoma.
This cohort study investigates the association between heparin-induced thrombocytopenia and bacterial infection in trauma patients.
This cohort study uses Swedish national databases to assess major bleeding and venous thromboembolism (VTE) following hip and knee replacement surgical procedures in patients with and without a family history of VTE.
This report describes a woman diagnosed with a rare case of concomitant heparin-induced thrombocytopenia and antiphospholipid antibody syndrome that presented with auricular necrosis.
This phase 3 randomized clinical trial compares the efficacy and safety of Janus kinase 2 inhibitor pacritinib with that of best available therapy, including ruxolitinib, in patients with myelofibrosis and thrombocytopenia.
This Teachable Moment describes the case of a 56-year-old man who presented to his primary care physician with bleeding gums and was subsequently diagnosed with primary immune thrombocytopenia.
A 45-year-old man with superior mesenteric vein thrombosis (SMVT) and with mesenteric ischemia was treated with partial small bowel resection and 2 weeks of enoxaparin. Three weeks later, he underwent bowel resection for recurrent SMVT and developed venous thromboembolism on intravenous heparin. Lab results were consistent with heparin-induced thrombocytopenia (4Ts score, 6). What would you do next?
This case-control study compares the hypercoagulability status of patients with calciphylaxis and renal disease with controls to identify conditions that are risk factors for developing calciphylaxis while controlling for chronic kidney disease.
A 39-year-old man with a history of ischemic stroke presented with right calf swelling and shortness of breath and was diagnosed with pulmonary embolism by CTPA. Testing 2 days later showed elevated titers of anticardiolipin and anti–β2 glycoprotein I antibodies and negative lupus anticoagulant screening assays. How would you interpret these results?
An 84-year-old woman with a history of chronic kidney disease, prior stroke, and hypertension but no personal or family history of bleeding disorders was admitted with a 2-week history of spontaneous subcutaneous ecchymoses and hematomas. She had normal vital signs, laboratory results showing isolated severe anemia but unremarkable for other causes of anemia, and a large soft-tissue hematoma in the left chest wall without evidence of internal hemorrhage. How do you interpret these test results?
This cohort study investigates whether a low serum calcium level is associated with an increase in the extent of bleeding in patients with intracerebral hemorrhage as measured by baseline hematoma volume and risk of hematoma expansion.
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