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    Colorectal Cancer

    Explore the latest in colorectal cancer, including advances in the diagnosis, management, screening, and prevention of the disease.

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    • Comparing Risk for Second Primary Cancers After Intensity-Modulated vs 3-Dimensional Conformal Radiation Therapy for Prostate Cancer, 2002-2015
      JAMA Oncology
      Research
      June 8, 2023

      This cohort study evaluates whether radiotherapy type (intensity-modulated radiotherapy vs 3-dimensional conformal radiotherapy) was associated with second primary cancer risk among older men treated for prostate cancer.

      Prostate Cancer Urology Urologic Cancer Radiation Oncology Oncology
      Full Text | pdf link PDF
    • Germline Genetic Testing After Cancer Diagnosis
      JAMA
      Research
      June 5, 2023

      This observational study describes the prevalence of germline genetic testing in California and Georgia between 2013 and 2019 among patients diagnosed with cancer.

      Endometrial Cancer Gastroenterology Gastrointestinal Cancer Cancer Genetics Cancer Epidemiology
      Full Text | pdf link PDF free
    • Frequency of Use and Outcomes of Colonoscopy in Individuals Older Than 75 Years
      JAMA Internal Medicine
      Research
      June 1, 2023

      This cross-sectional study with a nested cohort assesses the number of screening colonoscopies done in patients older than 75 years with a life expectancy of fewer than 10 years.

      Less is More Geriatrics Colorectal Surgery Cancer Screening, Prevention, Control Gastroenterology
      Full Text | pdf link PDF
    • Efficacy of Systemic Chemotherapy in Patients With Low-grade Mucinous Appendiceal Adenocarcinoma: A Randomized Crossover Trial
      JAMA Network Open
      Research
      June 1, 2023

      This randomized crossover trial evaluates the effectiveness of fluoropyrimidine-based systemic chemotherapy in patients with inoperable low-grade mucinous appendiceal adenocarcinoma.

      Oncology Gastroenterology and Hepatology Gastroenterology Gastrointestinal Cancer
      Full Text | pdf link PDF open access
    • Panitumumab Plus Trifluridine-Tipiracil as Anti–Epidermal Growth Factor Receptor Rechallenge Therapy for Refractory RAS Wild-Type Metastatic Colorectal Cancer: A Phase 2 Randomized Clinical Trial
      JAMA Oncology
      Research
      May 18, 2023

      This randomized clinical trial assesses progression-free survival among patients with RAS wild-type metastatic colorectal cancer receiving panitumumab plus standard-of-care trifluridine-tipiracil as third-line therapy.

      Targeted and Immune Cancer Therapy Oncology Surgery Surgical Oncology Gastroenterology and Hepatology
      Full Text | pdf link PDF open access
    • Long-term Quality of Life and Functional Outcome of Patients With Rectal Cancer Following a Watch-and-Wait Approach
      JAMA Surgery
      Research
      May 10, 2023

      This cohort study assesses quality of life and functional outcome of patients with rectal cancer who are followed up via a watch-and-wait approach.

      Oncology Surgery Surgical Oncology Urology Gastroenterology and Hepatology
      Full Text | pdf link PDF
    • Guiding Patients Through a “Watch-and-Wait” Approach for Rectal Cancer—Understanding the Functional Outcomes
      JAMA Surgery
      Opinion
      May 10, 2023
      Gastroenterology Gastrointestinal Cancer Oncology Gastroenterology and Hepatology
      Full Text | pdf link PDF
    • Association of Life Expectancy With Surveillance Colonoscopy Findings and Follow-up Recommendations in Older Adults
      JAMA Internal Medicine
      Research
      May 1, 2023

      This cohort study examines the association of estimated life expectancy with colonoscopy findings and recommendations for surveillance colonoscopy among adults older than 65 years in New Hampshire.

      Cancer Screening, Prevention, Control Cancer Epidemiology Geriatrics Gastroenterology and Hepatology Gastroenterology
      Full Text | pdf link PDF
    • Brugada Pattern, Tall Peaked T Waves, Absence of P Waves, and Broad QRS Complexes
      JAMA Internal Medicine
      Case Report
      May 1, 2023

      This case report presents the electrocardiogram findings of a patient in their 70s with chest tightness and shortness of breath for 5 hours and loss of consciousness for 10 minutes.

      Acid Base, Electrolytes, Fluids Acute Kidney Injury Cardiology Gastrointestinal Cancer Nephrology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Regorafenib, Ipilimumab, and Nivolumab for Patients With Microsatellite Stable Colorectal Cancer and Disease Progression With Prior Chemotherapy: A Phase 1 Nonrandomized Clinical Trial
      JAMA Oncology
      Research
      May 1, 2023

      This nonrandomized clinical trial assesses the recommended phase 2 dose of regorafenib, ipilimumab, and nivolumab immunotherapy for patients with refractory microsatellite stable metastatic colorectal cancer.

      Gastroenterology Gastrointestinal Cancer Targeted and Immune Cancer Therapy Oncology Gastroenterology and Hepatology
      Full Text | pdf link PDF
    • Immunotherapy Success for Microsatellite Stable Colorectal Cancers—Searching for the Horizon
      JAMA Oncology
      Opinion
      May 1, 2023
      Gastroenterology Gastrointestinal Cancer Targeted and Immune Cancer Therapy Oncology Gastroenterology and Hepatology
      Full Text | pdf link PDF
    • Comparative Effectiveness of 2 Interventions to Increase Breast, Cervical, and Colorectal Cancer Screening Among Women in the Rural US: A Randomized Clinical Trial
      JAMA Network Open
      Research
      April 28, 2023

      This randomized clinical trial assesses whether 2 tailored interventions delivered remotely were effective at increasing the rate of any or all needed cancer screenings in rural women.

      Oncology Women's Health Breast Cancer Cancer Screening, Prevention, Control Gastroenterology
      Full Text | pdf link PDF open access
    • Practice-Level Variation in Molecular Testing and Use of Targeted Therapy for Patients With Non–Small Cell Lung Cancer and Colorectal Cancer
      JAMA Network Open
      Research
      April 28, 2023

      This cross-sectional study compares rates of molecular testing and targeted therapy among patients with non–small cell lung cancer (NSCLC) and colorectal cancer (CRC) use by practice type and across practices.

      Health Policy Pharmacy and Clinical Pharmacology Genetics and Genomics Lung Cancer Oncology
      Full Text | pdf link PDF open access
    • Evaluation of Birth by Cesarean Delivery and Development of Early-Onset Colorectal Cancer
      JAMA Network Open
      Research
      April 27, 2023

      This case-control study conducted in Sweden examines the association between birth by cesarean delivery and development of early-onset colorectal cancer before age 50 years.

      Gastroenterology and Hepatology Obstetrics and Gynecology Oncology Pregnancy Surgery
      Full Text | pdf link PDF open access
    • Efficacy and Safety of Intraoperative Hyperthermic Intraperitoneal Chemotherapy for Locally Advanced Colon Cancer: A Phase 3 Randomized Clinical Trial
      JAMA Surgery
      Research
      April 26, 2023

      This phase 3 randomized clinical trial assesses locoregional control rates after hyperthermic intraperitoneal chemotherapy with mitomycin C during cytoreductive surgery among adults with locally advanced colorectal cancer in Spain.

      Surgery Surgical Oncology Oncology Gastroenterology and Hepatology Gastroenterology
      Full Text | pdf link PDF
    • Heated Intraperitoneal Chemotherapy for Locally Advanced Colon Cancer–Restarting the Fire
      JAMA Surgery
      Opinion
      April 26, 2023
      Gastroenterology Gastrointestinal Cancer Surgery Surgical Oncology Gastroenterology and Hepatology
      Full Text | pdf link PDF
    • Longitudinal Analysis of Cancer Risk in Children and Adults With Germline PTEN Variants
      JAMA Network Open
      Research
      April 24, 2023

      This cohort study evaluates the cancer spectrum and risks in children and adults with germline PTEN variants.

      Genetics and Genomics Oncology Cancer Genetics Pediatric Cancer Cancer Epidemiology
      Full Text | pdf link PDF open access
    • Association of Overweight, Obesity, and Recent Weight Loss With Colorectal Cancer Risk
      JAMA Network Open
      Research
      April 21, 2023

      This case-control study examines how recent weight loss of patients with colorectal cancer may affect estimates of the association of colorectal cancer risk with overweight or obesity.

      Nutrition, Obesity, Exercise Obesity Lifestyle Behaviors Diet Gastroenterology and Hepatology
      Full Text | pdf link PDF open access
    • Early Detection of Molecular Residual Disease and Risk Stratification for Stage I to III Colorectal Cancer via Circulating Tumor DNA Methylation
      JAMA Oncology
      Research
      April 20, 2023

      This cohort study investigates the effectiveness of circulating tumor DNA methylation in early detection of colorectal cancer recurrence.

      Cancer Biomarkers Surgery Surgical Oncology Oncology Gastroenterology and Hepatology
      Full Text | pdf link PDF
    • Liquid Biopsy Assessment of Molecular Residual Disease in Localized Colorectal Cancer: Is It Ready for Prime Time?
      JAMA Oncology
      Opinion
      April 20, 2023
      Oncology Surgery Surgical Oncology Pathology and Laboratory Medicine Gastroenterology
      Full Text | pdf link PDF
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