Explore the latest in critical care medicine, including management of respiratory failure, sepsis, HAI prevention, end-of-life care, and more.
This Special Communication describes a Bayesian reanalysis of a randomized clinical trial comparing the effects on mortality of venovenous extracorporeal membrane oxygenation (ECMO) vs conventional mechanical ventilation among patients with severe acute respiratory distress syndrome, performed because of divergence between the clinical vs statistical significance of the trial’s findings and continued controversy over the benefit of ECMO.
This randomized clinical trial compares the effects of prophylactic hypothermia targeted to a core temperature of 33°C-35°C vs usual normothermic emergency care on neurologic outcomes or independent living of adult patients with severe traumatic brain injury (TBI).
This Viewpoint examines how the term intensive care unit may contribute to patient and physician expectations of more invasive and aggressive therapies, and suggests that a change in the nomenclature may be a first step in realigning patient and physician expectations from burdensome treatment towoard a more patient-centered approach.
This cross-sectional study investigates whether ambulance response time to 9-1-1 calls were longer in low-income vs high-income areas and compares response times with national benchmarks of 4, 8, or 15 minutes across income quartiles.
This cluster randomized trial compares associations between commonly used decontamination strategies (chlorhexidine 2% mouthwash, selective oropharyngeal decontamination, and selective digestive tract decontamination) and occurrence of intensive care unit (ICU)–acquired bloodstream infections with multidrug-resistant gram-negative bacteria in ICUs with moderate to high levels of antibiotic resistance.
This randomized clinical trial compares the effects of high-flow nasal vs standard oxygen therapy on 28-day mortality among immunocompromised patients with acute hypoxemic respiratory failure.
This randomized clinical trial determines the optimal therapeutic dose, effect on kidney function, and adverse effects of human recombinant alkaline phosphatase in patients who are critically ill with sepsis-associated acute kidney injury.
This randomized clinical trial compares the effects of a multimodal program involving education and role-play in simulated patient care sequences vs no intervention on work-related stress and work-related outcomes among nurses working at adult intensive care units (ICUs) in France.
Following esophageal resection for cancer, a 73-year-old man was admitted to the ICU with pneumonia and progressive acute respiratory failure, and he was placed on mechanical ventilation. At day 5, his creatinine level continued to increase. How would you proceed?
In this Viewpoint, Eric Topol and Lionel Tarrasenko, a biomedical engineer known for developing early-warning systems in critical care settings, contrast the precision monitoring of jet engines with existing monitoring systems in patients, and discuss how sensors, artificial intelligence, and other contemporary digital technologies used to monitor the maintenance needs of engines can be used to personalize treatment and improve outcomes for patients without generating false alarms.
This case study examines a man in his 30s who presented 20 months after an emergency intubation with an iatrogenic retained nasal trumpet.
This randomized trial compares the effects of protocolized weaning via early extubation to noninvasive ventilation vs standard weaning from invasive ventilation on time to liberation from mechanical ventilation among adults with respiratory failure ready to wean but with an unsuccessful spontaneous breathing trial.
This randomized trial compares the effects of low vs intermediate tidal volumes on ventilator-free days and mortality among intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS).
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