Explore the latest in depressive disorders from The JAMA Network, including recent screening and treatment guidelines and advances in management in children and adults.
This consortium study of multiple data sets assesses whether patients with major depressive disorder had different degrees of genetic overlap with obesity-related traits.
This commentary discusses a study published in JAMA Psychiatry that examined whether a pediatrics-based behavioral intervention targeting anxiety and depression improved clinical outcome compared with referral to outpatient community mental health care.
This Viewpoint describes an organization created to share stories and experiences of medical professionals.
This randomized clinical trial tests the effectiveness of a psychosocial intervention to improve early adherence among primary care patients aged 55 years and older receiving newly initiated antidepressants for depression.
This Medical News article explores the nonmedical and medical uses of cognition enhancing drugs.
This Viewpoint summarizes a number of important issues related to the clinical use of ketamine for the treatment of psychiatric disorders addressed in the consensus statement and provides suggestions for addressing remaining concerns.
A 57-year-old man presented with a history of HIV, hyperlipidemia, and major depressive disorder reporting depression and insomnia. He was taking bupropion but recent life events led to increased depressive symptoms. How would you proceed?
This cohort study uses polygenic risk scores to evaluate a possible genetic association between major depressive disorder and alcohol dependence.
This study evaluates the magnitude of practice effects on the Measurement and Treatment Research to Improve Cognition in Schizophrenia Consensus Cognitive Battery in cognitive impairment associated with schizophrenia and examines which characteristics were associated with improvement in placebo conditions.
This cohort study evaluates reward prediction errors in patients with major depressive disorder vs those without depression using functional neuroimaging, computational modeling, and smartphone-based data.
This randomized clinical trial determines the efficacy of a depression prevention strategy among mothers whose families are enrolled in Head Start.
This randomized clinical trial compares the effects on symptom remission of switching to bupropion, adding bupropion, or adding aripiprazole to baseline treatment among Veterans Affairs patients with antidepressant-resistant major depressive disorder.
This cohort study characterizes the trajectory of depressive symptoms over 28 years prior to dementia diagnosis to determine whether depressive symptoms carry risk for dementia.
This systematic review and meta-analysis examines the associations of the peripheral and cerebral forms of microvascular dysfunction with late-life depression.