Explore the latest in depressive disorders, including recent screening and treatment guidelines and advances in management in children and adults.
This prespecified secondary analysis of a randomized clinical trial discusses the development of an individualized treatment rule using machine learning methods for guided vs self-guided internet-delivered cognitive behavioral therapy based on a rich set of baseline predictors.
This cross-sectional study used linear mixed modeling of polygenic scores to estimate the association of genetic nurture across a range of parental traits with offspring lifetime depression and neuroticism.
This systematic review and meta-analysis evaluates depression and anxiety among children and adolescents during vs before the COVID-19 pandemic.
This prognostic study identifies subtypes of late-life depression and examines their depression trajectory by bipartite network clustering during psychosocial interventions.
This cohort study evaluates associations between familial risk of depression and cognitive performance in 4 independent cohorts with varied depth of assessment, using both family history and genetic risk measures.
This randomized clinical trial evaluates depression improvement (symptoms and diagnosis) among pregnant individuals from diverse backgrounds randomized to brief interpersonal psychotherapy vs enhanced usual care.
This metabolome-wide association study evaluates the association of metabolic factors and the human gut microbiome and metabolome with major depressive disorder.
This systematic review and meta-analysis compares depression rating outcomes with ketamine vs electroconvulsive therapy in adults with major depressive episode and compares response and remission rates, number of sessions to response and remission, and adverse effects.
This article discusses 2 possible mechanisms of action of electroconvulsive therapy.
This cohort study assesses changes in anxiety and depression following smoking cessation using 3 confirmatory coprimary analytical approaches.
This cohort study assesses the association of recent fatherhood with antidepressant treatment compared with men who did not have a child in the previous year.
This cohort study investigates the association of changes in adipokines, inflammatory factors, mood, and physical activity with alterations in cognitive function after bariatric surgery.
This survey study of more than 1 million Korean adolescents examines whether the observed sadness and suicidality in the early to middle periods of the COVID-19 pandemic differed from the expected level and investigates changes in risk factors for sadness and suicidality.
This cohort study investigates the association of cannabis use disorder with risk of psychotic or nonpsychotic unipolar depression and bipolar disorder in Denmark.
This cohort study examines clinical pain trajectories with repeated ketamine administration to explore whether racemic ketamine dose, pretreatment depressive, or pretreatment anxiety symptoms mediate pain relief in patients with treatment-resistant chronic pain.
This randomized clinical trial compares the effectiveness of immediate referral strategy with short-term management of symptoms among pregnant and peripartum persons with screen-detected depression.
This cohort study investigates the association between self-reported COVID-19–like symptoms vs SARS-CoV-2 seropositivity and subsequent depression or anxiety in a nationally representative French population.
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