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    Diabetic Retinopathy

    Explore the latest in diabetic retinopathy, including updates in epidemiology and advances in diagnosis and treatment of the disorder.

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    • Accuracy of Artificial Intelligence in Estimating Best-Corrected Visual Acuity From Fundus Photographs in Eyes With Diabetic Macular Edema
      JAMA Ophthalmology
      Research
      June 8, 2023

      This diagnostic/prognostic study uses data and color fundus photographs from a randomized clinical trial involving patients undergoing treatment of diabetic macular edema to enable artificial intelligence systems to estimate best-corrected visual acuity and to evaluate the accuracy of those estimates.

      Retinal Disorders Health Informatics Ophthalmic Imaging Ophthalmology Macular Diseases
      Full Text | pdf link PDF
    • Systemic Adverse Events Among Patients With Diabetes Treated With Intravitreal Anti–Vascular Endothelial Growth Factor Injections
      JAMA Ophthalmology
      Research
      June 1, 2023

      This cohort study evaluates the risks of adverse events associated with intravitreal anti–vascular endothelial growth factor injections in individuals with diabetes.

      Clinical Pharmacy and Pharmacology Ophthalmology Adverse Drug Events Retinal Disorders Diabetes and Endocrinology
      Full Text | pdf link PDF
    • Difficulty in Assessing the Systemic Adverse Effects of Intravitreal Anti–Vascular Endothelial Growth Factor Therapy
      JAMA Ophthalmology
      Opinion
      June 1, 2023
      Ophthalmology Adverse Drug Events Pharmacoepidemiology Retinal Disorders
      Full Text | pdf link PDF
    • Assessment of Parafoveal Diabetic Macular Ischemia on Optical Coherence Tomography Angiography Images to Predict Diabetic Retinal Disease Progression and Visual Acuity Deterioration
      JAMA Ophthalmology
      Research
      May 25, 2023

      This cohort study investigates the association of the deep learning–based diabetic macular ischemia with the subsequent risk of diabetic retinopathy progression, diabetic macular edema development, and visual acuity deterioration.

      Diabetes Diabetes and Endocrinology Retinal Disorders Health Informatics Ophthalmic Imaging
      Full Text | pdf link PDF has multimedia
    • Incidence and Progression of Diabetic Retinopathy in American Indian and Alaska Native Individuals Served by the Indian Health Service, 2015-2019
      JAMA Ophthalmology
      Research
      April 1, 2023

      This cohort study investigates the rates of incidence and progression for diabetic retinopathy in American Indian and Alaska Native individuals.

      Ophthalmology Diabetes Retinal Disorders Diabetes and Endocrinology Equity, Diversity, and Inclusion
      Full Text | pdf link PDF open access
    • Use of Teleophthalmology to Evaluate the Incidence and Progression of Diabetic Retinopathy
      JAMA Ophthalmology
      Opinion
      April 1, 2023
      Ophthalmic Imaging Ophthalmology Diabetes Retinal Disorders Diabetes and Endocrinology
      Full Text | pdf link PDF
    • Global Prevalence of Diabetic Retinopathy in Pediatric Type 2 Diabetes: A Systematic Review and Meta-analysis
      JAMA Network Open
      Research
      March 17, 2023

      This systematic review and meta-analysis uses data from observational studies to estimate the global prevalence of diabetic retinopathy among patients with pediatric type 2 diabetes.

      Diabetes and Endocrinology Diabetes Ophthalmology Pediatrics Ophthalmic Imaging
      Full Text | pdf link PDF open access
    • Cost-effectiveness of Aflibercept Monotherapy vs Bevacizumab First Followed by Aflibercept If Needed for Diabetic Macular Edema
      JAMA Ophthalmology
      Research
      March 1, 2023

      This economic evaluation determines the cost-effectiveness of aflibercept monotherapy vs bevacizumab first, then aflibercept for suboptimal response, in treating patients with diabetic macular edema.

      Health Care Economics, Insurance, Payment Pharmacoeconomics Retinal Disorders Diabetes and Endocrinology Macular Diseases
      Full Text | pdf link PDF has multimedia
    • Anti–Vascular Endothelial Growth Factor Therapy for Complications of Diabetic Retinopathy—From Treatment to Prevention?
      JAMA Ophthalmology
      Opinion
      March 1, 2023
      Ophthalmology Diabetes Retinal Disorders Diabetes and Endocrinology
      Full Text | pdf link PDF
    • Four-Year Visual Outcomes in the Protocol W Randomized Trial of Intravitreous Aflibercept for Prevention of Vision-Threatening Complications of Diabetic Retinopathy
      JAMA
      Research
      February 7, 2023

      This randomized clinical trial analyzes the effects of aflibercept injections vs sham for reducing disease progression and improving long-term visual acuity in patients with nonproliferative diabetic retinopathy.

      Ophthalmology Retinal Disorders Diabetes and Endocrinology Diabetes Macular Diseases
      Full Text | pdf link PDF
    • Outcomes and Complications of Pars Plana Vitrectomy for Tractional Retinal Detachment in People With Diabetes: A Systematic Review and Meta-analysis
      JAMA Ophthalmology
      Research
      February 1, 2023

      This systematic review and meta-analysis investigates the outcomes of pars plana vitrectomy for the treatment of diabetic tractional retinal detachment.

      Retinal Disorders Ophthalmology Diabetes Diabetes and Endocrinology
      Full Text | pdf link PDF open access
    • What Defines Successful Surgery for Diabetic Tractional Retinal Detachment?
      JAMA Ophthalmology
      Opinion
      February 1, 2023
      Ophthalmology Retinal Disorders Diabetes and Endocrinology Diabetes
      Full Text | pdf link PDF
    • A Step Forward in Understanding Treatment Approaches for Diabetic Macular Edema
      JAMA Ophthalmology
      Opinion
      January 1, 2023

      This Viewpoint discusses new treatment approaches for diabetic macular edema.

      Ophthalmology Diabetes Retinal Disorders Diabetes and Endocrinology Macular Diseases
      Full Text | pdf link PDF
    • Association of Treatment Type and Loss to Follow-up With Tractional Retinal Detachment in Proliferative Diabetic Retinopathy
      JAMA Ophthalmology
      Research
      January 1, 2023

      This case-control study investigates the association of tractional retinal detachment in proliferative diabetic retinopathy with intravitreal injections compared with other treatment regimens.

      Retinal Disorders Diabetes and Endocrinology Diabetes Ophthalmology
      Full Text | pdf link PDF has multimedia
    • Acquired Nonpigmented Vitreous Cyst Associated With Regressed Diabetic Neovascularization
      JAMA Ophthalmology
      Case Report
      January 1, 2023

      This case report describes a 48-year-old man with acquired nonpigmented vitreous cyst associated with regressed diabetic neovascularization.

      Ophthalmology Retinal Disorders Diabetes and Endocrinology Diabetes
      Full Text | pdf link PDF
    • Challenges in the Clinical Management of Proliferative Diabetic Retinopathy: Treatment Choice and Follow-up
      JAMA Ophthalmology
      Opinion
      January 1, 2023
      Ophthalmology Diabetes Retinal Disorders Diabetes and Endocrinology
      Full Text | pdf link PDF
    • Global Estimates of Diabetic Retinopathy Prevalence and Progression in Pregnant Individuals With Preexisting Diabetes: A Meta-analysis
      JAMA Ophthalmology
      Research
      November 1, 2022

      This study repeats previous meta-analyses of the prevalence and progression of diabetic retinopathy in pregnant populations with preexisting diabetes.

      Ophthalmology Diabetes Retinal Disorders Diabetes and Endocrinology Obstetrics and Gynecology
      Full Text | pdf link PDF
    • Representation of Race and Ethnicity in Randomized Clinical Trials of Diabetic Macular Edema and Retinal Vein Occlusion Compared to 2010 US Census Data
      JAMA Ophthalmology
      Research
      November 1, 2022

      This cross-sectional study evaluates the representation of racial and ethnic minority groups in randomized clinical trials of diabetic macular edema and retinal vein occlusion compared with US Census data.

      Ophthalmology Research, Methods, Statistics Retinal Disorders Equity, Diversity, and Inclusion Macular Diseases
      Full Text | pdf link PDF
    • Association of Predominantly Peripheral Lesions on Ultra-Widefield Imaging and the Risk of Diabetic Retinopathy Worsening Over Time
      JAMA Ophthalmology
      Research
      October 1, 2022

      This cohort study analyzes ultra-widefield imaging data to determine whether predominantly peripheral lesions are associated with increased disease worsening beyond the risk associated with baseline Diabetic Retinopathy Severity Scale score.

      Ophthalmic Imaging Ophthalmology Diabetes Retinal Disorders Diabetes and Endocrinology
      Full Text | pdf link PDF has multimedia
    • Association of Ultra-Widefield Fluorescein Angiography–Identified Retinal Nonperfusion and the Risk of Diabetic Retinopathy Worsening Over Time
      JAMA Ophthalmology
      Research
      October 1, 2022

      This cohort study analyzes 4 years of longitudinal data to assess worsening in Diabetic Retinopathy Severity Score in association with changes in retinal nonperfusion from baseline as captured by ultra-widefield fluorescein angiography.

      Ophthalmic Imaging Ophthalmology Retinal Disorders Diabetes and Endocrinology Diabetes
      Full Text | pdf link PDF
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