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    Cutaneous Drug Reactions

    Explore the latest in cutaneous drug reactions, including advances in understanding the mechanisms and genetics of adverse events.

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    • Development of a Skin-Directed Scoring System for Stevens-Johnson Syndrome and Epidermal Necrolysis: A Delphi Consensus Exercise
      JAMA Dermatology
      Review
      May 31, 2023

      This Delphi consensus exercise with more than 50 dermatology experts explores the need for a skin-directed epidermal necrolysis assessment tool that incorporates disease morphologic traits, terminology, and sites of involvement.

      Dermatology Consensus Statements Allergy and Clinical Immunology Clinical Pharmacy and Pharmacology Adverse Drug Events
      Full Text | pdf link PDF | CME & MOC is active quiz has multimedia
    • Evaluation of Plasmapheresis vs Immunoglobulin as First Treatment After Ineffective Systemic Corticosteroid Therapy for Patients With Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
      JAMA Dermatology
      Research
      May 1, 2023

      This retrospective cohort study evaluated the outcomes of administering plasmapheresis or intravenous immunoglobulin therapy first after ineffective systemic corticosteroid treatment among inpatients with Stevens-Johnson syndrome and toxic epidermal necrolysis in Japan.

      Dermatology Clinical Pharmacy and Pharmacology Adverse Drug Events Allergy and Clinical Immunology
      Full Text | pdf link PDF
    • Nonhealing Cutaneous Ulcers in a Patient With Myelodysplastic Syndrome
      JAMA Oncology
      Case Report
      April 13, 2023

      A 75-year-old man with myelodysplastic syndrome that has been well controlled with lenalidomide develops multiple nonhealing cutaneous ulcers. What is your diagnosis?

      Dermatology Clinical Pharmacy and Pharmacology Hematology Oncology Hematologic Cancer
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Paradoxical Psoriasiform Eruptions in Children Receiving Tumor Necrosis Factor α Inhibitors
      JAMA Dermatology
      Research
      April 12, 2023

      This case series characterizes the clinical features and the clinical time course of TNF inhibitor–induced psoriasiform eruptions in children.

      Dermatology Pediatrics Gastroenterology and Hepatology Gastroenterology Inflammatory Bowel Disease
      Full Text | pdf link PDF
    • Worldwide Prevalence of Antibiotic-Associated Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review and Meta-analysis
      JAMA Dermatology
      Research
      April 1, 2023

      This systematic review and meta-analysis of 38 studies including 2917 patients evaluates the prevalence of antibiotics associated with Stevens-Johnson syndrome and toxic epidermal necrolysis worldwide.

      Dermatology Pharmacoepidemiology Infectious Diseases Antibiotic Use, Overuse, Resistance, Stewardship Adverse Drug Events
      Full Text | pdf link PDF
    • Association of Immune-Related Adverse Events With Efficacy of Atezolizumab in Patients With Non–Small Cell Lung Cancer: Pooled Analyses of the Phase 3 IMpower130, IMpower132, and IMpower150 Randomized Clinical Trials
      JAMA Oncology
      Research
      April 1, 2023

      This analysis of pooled data from 3 randomized clinical trials evaluates the association between immune-related adverse events and atezolizumab efficacy in patients with advanced non–small cell lung cancer.

      Dermatology Targeted and Immune Cancer Therapy Oncology Lung Cancer
      Full Text | pdf link PDF open access
    • Worsening Rash in a Patient With Metastatic Breast Cancer
      JAMA Oncology
      Case Report
      April 1, 2023

      A 56-year-old woman with metastatic hormone receptor–positive, ERBB2-negative breast cancer presents with pruritic, erythematous, scaly macules and papules on her forearms, faces, chest, and upper back. What is your diagnosis?

      Dermatology Clinical Challenge Breast Cancer Oncology Women's Health
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Numerous Ulcerated Plaques of the Trunk and Extremities in a Patient Receiving Long-term Hydroxyurea Therapy
      JAMA Dermatology
      Case Report
      April 1, 2023

      A woman in her 80s initially presented with numerous, primarily photodistributed, crusted, and ulcerated plaques of the trunk and extremities and a medical history of essential thrombocytosis treated with hydroxyurea for 14 years. What is your diagnosis?

      Clinical Pharmacy and Pharmacology Hematology Adverse Drug Events Clinical Challenge Dermatology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Drug Reaction With Eosinophilia and Systemic Symptoms
      JAMA Dermatology
      Patient Information
      March 1, 2023

      This Patient Page describes the symptoms, diagnosis, and treatment of drug reaction with eosinophilia and systemic symptoms.

      Allergy and Clinical Immunology Patient Information JAMA Dermatology Patient Information Adverse Drug Events Dermatology
      Full Text | pdf link PDF free
    • Outcomes Associated With Neutropenia and Lymphopenia in Epidermal Necrolysis: A Single-Center Retrospective Study of 147 Patients
      JAMA Dermatology
      Research
      March 1, 2023

      This retrospective cohort study examines the association of lymphocyte and neutrophil levels with treatment outcomes in 147 patients with epidermal necrolysis in France.

      Allergy and Clinical Immunology Dermatology Clinical Pharmacy and Pharmacology Adverse Drug Events
      Full Text | pdf link PDF
    • High-Dose Vitamin D for the Management of Toxic Erythema of Chemotherapy in Hospitalized Patients
      JAMA Dermatology
      Research
      February 1, 2023

      This case series describes the outcome of high-dose vitamin D treatment in 6 inpatients with acute skin injury.

      Dermatology Adverse Drug Events Oncology Clinical Pharmacy and Pharmacology
      Full Text | pdf link PDF
    • Sudden Conjunctivitis, Lymphopenia, and Rash Combined With Hemodynamic Changes (SCoRCH) After Trimethoprim-Sulfamethoxazole Use: A Case Series Study of a Hypersensitivity Reaction
      JAMA Dermatology
      Research
      January 1, 2023

      This retrospective case series study of 7 patients describes the characteristic symptoms of a potentially life-threatening hypersensitivity reaction to trimethoprim-sulfamethoxazole SCoRCH, or sudden conjunctivitis, lymphopenia, and rash combined with hemodynamic changes.

      Allergy and Clinical Immunology Clinical Pharmacy and Pharmacology Hematology Infectious Diseases Antibiotic Use, Overuse, Resistance, Stewardship
      Full Text | pdf link PDF
    • Association of Intraoperative Antibiotic Irrigation With Systemic Contact Dermatitis
      JAMA Dermatology
      Research
      January 1, 2023

      This case series describes the development of morbilliform drug eruption after breast surgery.

      Breast Cancer Oncology Surgical Oncology Perioperative Care and Consultation Women's Health
      Full Text | pdf link PDF
    • Tocilizumab for Corticosteroid-Refractory Immune Checkpoint Inhibitor–Induced Generalized Morphea
      JAMA Dermatology
      Case Report
      January 1, 2023

      This case report describes a 78-year old woman with a stage IIA BRAF wild-type melanoma on the left leg who experienced a grade 2 vitiligo, a marked skin thickening, and painful swelling of the limbs.

      Dermatology Rheumatology Connective Tissue Disease of the Skin Targeted and Immune Cancer Therapy Oncology
      Full Text | pdf link PDF
    • Acneiform Eruption Following Elexacaftor-Tezacaftor-Ivacaftor Treatment in Patients With Cystic Fibrosis
      JAMA Dermatology
      Research
      January 1, 2023

      This case series describes the clinicopathological features and treatment response of acneiform eruptions following elexacaftor-tezacaftor-ivacaftor treatment in patients with cystic fibrosis.

      Dermatology Pulmonary Medicine
      Full Text | pdf link PDF
    • Spectrum of Dermatologic Adverse Events Associated With Amivantamab Use
      JAMA Dermatology
      Research
      January 1, 2023

      This case series describes the different dermatologic adverse events that patients experienced while using amivantamab.

      Dermatology Clinical Pharmacy and Pharmacology Targeted and Immune Cancer Therapy Adverse Drug Events Oncology
      Full Text | pdf link PDF
    • Predicting DRESS Syndrome Recurrence—The ReDRESS Score
      JAMA Dermatology
      Research
      December 1, 2022

      This cross-sectional study of DRESS syndrome cases creates a model capable of predicting recurrence to identify patients most at risk.

      Dermatology Clinical Pharmacy and Pharmacology Adverse Drug Events Allergy and Clinical Immunology
      Full Text | pdf link PDF
    • Systemic Interventions for Treatment of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: Summary of a Cochrane Review
      JAMA Dermatology
      December 1, 2022

      This clinical evidence synopsis summarizes a Cochrane review on the use of systemic immunomodulatory therapies to decrease mortality rates in Stevens-Johnson syndrome/toxic epidermal necrolysis.

      Critical Care Medicine Dermatology Infectious Diseases Sepsis Adverse Drug Events
      Full Text | pdf link PDF
    • Risk Factors for Vancomycin Drug Reaction With Eosinophilia and Systemic Symptoms Syndrome
      JAMA Dermatology
      Research
      December 1, 2022

      This case-control study uses single-institution data to explore risk factors associated with vancomycin drug reaction with eosinophilia and systemic systems (DRESS) syndrome.

      Clinical Pharmacy and Pharmacology Adverse Drug Events Infectious Diseases Antibiotic Use, Overuse, Resistance, Stewardship Allergy and Clinical Immunology
      Full Text | pdf link PDF
    • Incidence of Cutaneous Adverse Events With Phosphoinositide 3-Kinase Inhibitors as Adjuvant Therapy in Patients With Cancer: A Systematic Review and Meta-analysis
      JAMA Oncology
      Research
      November 1, 2022

      This systematic review with meta-analysis examines the incidence of phosphoinositide 3-kinase inhibitor–associated cutaneous adverse events in patients with cancer.

      Clinical Pharmacy and Pharmacology Targeted and Immune Cancer Therapy Adverse Drug Events Oncology Dermatology
      Full Text | pdf link PDF
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