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    Clinical Pharmacy and Pharmacology

    Explore the latest in clinical pharmacy and pharmacology, including topics in drug safety, development, pharmacogenetics, and pharmacoeconomics.

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    • Association of Nonsteroidal Anti-inflammatory Drug Prescriptions With Kidney Disease Among Active Young and Middle-aged Adults
      JAMA Network Open
      Research
      February 15, 2019

      This cohort study evaluates the association between use of nonsteroidal anti-inflammatory drugs and incident acute kidney injury and chronic kidney disease in US Army soldiers.

      Nephrology Pain Medicine Chronic Kidney Disease Adverse Drug Events Pharmacy and Clinical Pharmacology
      Full Text | pdf link PDF open access
    • Evaluating Risks and Benefits of Evolving Systemic Treatments of Neuroendocrine Tumors
      JAMA Oncology
      Opinion
      February 14, 2019
      Targeted and Immune Cancer Therapy Cancer Survivorship Toxicology Adverse Drug Events Oncology
      Full Text | pdf link PDF
    • Therapeutic Options for Neuroendocrine Tumors: A Systematic Review and Network Meta-analysis
      JAMA Oncology
      Research
      February 14, 2019

      This systematic review and meta-analysis examines randomized clinical trials to assess the safety and efficacy of medications used for patients with gastrointestinal and pancreatic neuroendocrine tumors.

      Research, Methods, Statistics Targeted and Immune Cancer Therapy Oncology Gastroenterology Gastrointestinal Cancer
      Full Text | pdf link PDF
    • The Argument for Sterile Loading of All Intravitreal Injections and the Benefit of Replicated Results
      JAMA Ophthalmology
      Opinion
      February 14, 2019

      This Viewpoint summarizes the findings of 2 studies on the association of intravitreal injections with endophthalmitis and advocates for the use of prepackaged sterile injections.

      Ophthalmology Retinal Disorders
      Full Text | pdf link PDF
    • Statins Work, But Only in People Who Take Them
      JAMA Cardiology
      Opinion
      February 13, 2019
      Cardiology Dyslipidemia Cardiovascular Risk Factors
      Full Text | pdf link PDF
    • Association of Statin Adherence With Mortality in Patients With Atherosclerotic Cardiovascular Disease
      JAMA Cardiology
      Research
      February 13, 2019

      This cohort study explores the association of statin adherence with mortality in stable patients with atherosclerotic cardiovascular disease in the United States.

      Cardiology Dyslipidemia Cardiovascular Risk Factors
      Full Text | pdf link PDF has multimedia
    • Increasing Smoking Cessation in the United States: Expanding the Availability of Over-the-Counter Medications
      JAMA
      Opinion
      February 12, 2019

      This Viewpoint argues that adoption of a combination of varenicline, nicotine replacement therapy, and behavioral support as first-line treatment for tobacco addiction could increase smoking cessation rates in the United States and proposes that varenicline be made an over-the-counter medication to help more smokers quit cigarettes and improve population health.

      Tobacco and e-Cigarettes Public Health
      Full Text | pdf link PDF
    • County-Level Opioid Prescribing in the United States, 2015 and 2017
      JAMA Internal Medicine
      Research
      February 11, 2019

      This study examines trends in opioid prescribing at the US national and county levels during 2015 and 2017.

      Substance Use and Addiction Opioids Pain Medicine
      Full Text | pdf link PDF
    • Reducing the Expert Halo Effect on Pharmacy and Therapeutics Committees
      JAMA
      Opinion
      February 5, 2019

      This Viewpoint discusses the bias experts can introduce to pharmacy and therapeutics committees tasked with evaluating the value of adding new drugs to practice formularies and proposes strategies to reduce bias including anonymous voting; allowing members time for thoughtful review; and training members in study design, critical appraisal, and cost-benefit analysis.

      Pharmacoeconomics
      Full Text | pdf link PDF
    • Association of Fetal Growth Restriction With Neurocognitive Function After Repeated Antenatal Betamethasone Treatment vs Placebo: Secondary Analysis of the ACTORDS Randomized Clinical Trial
      JAMA Network Open
      Research
      February 1, 2019

      This secondary analysis of a randomized clinical trial evaluates whether fetal growth restriction is associated with the effects of repeated doses of antenatal betamethasone on neurocognitive function in a cohort of children followed up in midchildhood.

      Pregnancy Obstetrics and Gynecology Obstetrics Women's Health Pediatrics
      Full Text | pdf link PDF open access
    • Anticoagulation Therapy in Non–ST-Segment Elevation Acute Coronary Syndrome
      JAMA Internal Medicine
      Opinion
      February 1, 2019
      Anticoagulation Less is More Acute Coronary Syndromes Cardiology Ischemic Heart Disease
      Full Text | pdf link PDF
    • Comparison of Antibiotic Prescribing for Pediatric Community-Acquired Pneumonia in Children’s and Non-Children’s Hospitals
      JAMA Pediatrics
      Research
      February 1, 2019

      This analysis uses hospital billing databases of inpatient discharges to compare antibiotic prescribing for community-acquired pneumonia by hospital type.

      Pediatrics Infectious Diseases Antibiotic Use, Overuse, Resistance, Stewardship Pneumonia Pulmonary Medicine
      Full Text | pdf link PDF
    • Antipsychotics, Excess Deaths, and Paradoxes of Child Psychiatry
      JAMA Psychiatry
      Opinion
      February 1, 2019
      Attention Deficit/Hyperactivity Disorders Depressive Disorders Adverse Drug Events Schizophrenia Spectrum and Other Psychotic Disorders Psychiatry
      Full Text | pdf link PDF
    • A Status Update on the Association Between Antidepressants and Fractures: Breaking Up?
      JAMA Psychiatry
      Opinion
      February 1, 2019
      Depressive Disorders Geriatrics Psychiatry Adverse Drug Events Trauma and Injury
      Full Text | pdf link PDF
    • Association of Antipsychotic Treatment With Risk of Unexpected Death Among Children and Youths
      JAMA Psychiatry
      Research
      February 1, 2019

      This cohort study of Tennessee Medicaid enrollees from 1999 through 2014 investigates the risk of unexpected death among children and youths aged 5 through 24 years without psychosis who are new users of antipsychotic medications compared with new users of control medications.

      Attention Deficit/Hyperactivity Disorders Depressive Disorders Psychiatry Child and Adolescent Psychiatry Adverse Drug Events
      Full Text | pdf link PDF
    • Association Between Antidepressant Drug Use and Hip Fracture in Older People Before and After Treatment Initiation
      JAMA Psychiatry
      Research
      February 1, 2019

      This population-based study examines the occurrence of hip fractures in elderly individuals before and after initiation of antidepressant medications.

      Depressive Disorders Geriatrics Psychiatry Adverse Drug Events Trauma and Injury
      Full Text | pdf link PDF
    • Association of Noninfectious Pneumonia With Ustekinumab Use
      JAMA Dermatology
      Research
      February 1, 2019

      This study examines the FDA Adverse Event Reporting System and PubMed databases for cases of noninfectious pneumonia acquired after FDA approval of the drug ustekinumab.

      Pulmonary Medicine Pneumonia Adverse Drug Events Dermatology Psoriasis
      Full Text | pdf link PDF
    • Clinical Characterization of Immunotherapy-Related Pruritus Among Patients Seen in 2 Oncodermatology Clinics
      JAMA Dermatology
      Research
      February 1, 2019

      This cohort study assesses self-reported quality of life among patients referred to oncodermatology clinics for pruritus associated with immunotherapy.

      Targeted and Immune Cancer Therapy Oncology Adverse Drug Events Dermatology
      Full Text | pdf link PDF
    • Association of Dipeptidyl Peptidase 4 Inhibitor Use With Risk of Bullous Pemphigoid in Patients With Diabetes
      JAMA Dermatology
      Research
      February 1, 2019

      This case-control study examines the association between the use of dipeptidyl peptidase 4 inhibitors and the risk of developing bullous pemphigoid in patients with diabetes.

      Diabetes Diabetes and Endocrinology Dermatology Adverse Drug Events Pharmacoepidemiology
      Full Text | pdf link PDF
    • Association of Blepharitis and Ectropion With Tumor Necrosis Factor α Inhibitor Treatment in Crohn Disease
      JAMA Ophthalmology
      Opinion
      February 1, 2019

      This case study investigates the possible association of tumor necrosis factor α inhibitor treatment with adverse ophthalmologic events, in this case blepharitis and ectropion.

      External Eye Disease Ophthalmology Adverse Drug Events Gastroenterology and Hepatology Gastroenterology
      Full Text | pdf link PDF
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