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    Clinical Pharmacy and Pharmacology

    Explore the latest in clinical pharmacy and pharmacology, including topics in drug safety, development, pharmacogenetics, and pharmacoeconomics.

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    • FDA Approves First Over-the-counter Combined COVID-19 and Flu Test
      JAMA
      News
      March 28, 2023
      Infectious Diseases Influenza Coronavirus (COVID-19)
      Full Text | pdf link PDF free
    • Expectations and Prior Experiences Associated With Adverse Effects of COVID-19 Vaccination
      JAMA Network Open
      Research
      March 27, 2023

      This cohort study investigates whether positive and negative expectations are associated with systemic adverse effects among adults receiving their second dose of COVID-19 vaccines.

      Infectious Diseases Vaccination Pharmacy and Clinical Pharmacology Coronavirus (COVID-19) Adverse Drug Events
      Full Text | pdf link PDF open access
    • Family Conferences to Facilitate Deprescribing in Older Outpatients With Frailty and With Polypharmacy: The COFRAIL Cluster Randomized Trial
      JAMA Network Open
      Research
      March 27, 2023

      This cluster randomized trial evaluates the effects of general practitioner–led family conferences on deprescribing and hospitalizations in community-dwelling older adults with frailty.

      Geriatrics Shared Decision Making and Communication Pharmacy and Clinical Pharmacology
      Full Text | pdf link PDF open access
    • Association of Antibiotic Receipt With Survival Among Patients With Metastatic Pancreatic Ductal Adenocarcinoma Receiving Chemotherapy
      JAMA Network Open
      Research
      March 23, 2023

      This cohort study examines survival among patients receiving antibiotic therapy concurrent with chemotherapy with gemcitabine or fluorouracil for metastatic pancreatic ductal adenocarcinoma.

      Oncology Pharmacoepidemiology Pharmacy and Clinical Pharmacology Antibiotic Use, Overuse, Resistance, Stewardship Infectious Diseases
      Full Text | pdf link PDF open access
    • Association of Treatment With Nirmatrelvir and the Risk of Post–COVID-19 Condition
      JAMA Internal Medicine
      Research
      March 23, 2023

      This cohort study examines the association of treatment with nirmatrelvir in the acute phase of COVID-19 and risk of post–COVID-19 condition.

      Infectious Diseases Pharmacoepidemiology Coronavirus (COVID-19)
      Full Text | pdf link PDF open access
    • Trends in the Use of Oral Anticoagulants for Adults With Venous Thromboembolism in the US, 2010-2020
      JAMA Network Open
      Research
      March 22, 2023

      This cohort study uses data from Medicare fee-for-service and a commercial insurance database to evaluate prescribing patterns of oral anticoagulants for patients with venous thromboembolism and identify clinical events that precede treatment changes.

      Cardiology Pharmacoepidemiology Anticoagulation Venous Thromboembolism
      Full Text | pdf link PDF open access
    • Prevalence of Statin Use for Primary Prevention of Atherosclerotic Cardiovascular Disease by Race, Ethnicity, and 10-Year Disease Risk in the US: National Health and Nutrition Examination Surveys, 2013 to March 2020
      JAMA Cardiology
      Research
      March 22, 2023

      This cross-sectional study evaluates statin use for primary prevention of atherosclerotic cardiovascular disease in the US by 10-year risk and by race and ethnicity.

      Cardiology Dyslipidemia Cardiovascular Risk Factors Equity, Diversity, and Inclusion
      Full Text | pdf link PDF
    • Effect of Higher-Dose Ivermectin for 6 Days vs Placebo on Time to Sustained Recovery in Outpatients With COVID-19: A Randomized Clinical Trial
      JAMA
      Research
      March 21, 2023

      This platform randomized clinical trial examines the effectiveness of ivermectin at a targeted dose of 600 μg/kg daily compared with placebo for the treatment of early mild to moderate COVID-19.

      Infectious Diseases Coronavirus (COVID-19)
      Full Text | pdf link PDF free
    • At a Higher Dose and Longer Duration, Ivermectin Still Not Effective Against COVID-19
      JAMA
      Opinion
      March 21, 2023
      Infectious Diseases Coronavirus (COVID-19)
      Full Text | pdf link PDF free
    • Highlights From the American College of Cardiology’s 2023 Scientific Session: the Ketogenic Diet and Cardiac Events, a Wearable Sensor to Predict Troponin Levels, Bempedoic Acid for Statin Intolerance, and More
      JAMA
      News
      March 20, 2023

      This Medical News article discusses research presented at the American College of Cardiology and World Congress of Cardiology conference this March.

      Dyslipidemia Cardiovascular Risk Factors Cardiology Lifestyle Behaviors Diet
      Full Text | pdf link PDF free has multimedia
    • Projected COVID-19 Mortality Reduction From Paxlovid Rollout
      JAMA Health Forum
      Research
      March 17, 2023

      This decision analytical model study assesses projections of simulated effects of Paxlovid rollout on hospitalizations and mortality using 10 models.

      Health Policy Coronavirus (COVID-19) Infectious Diseases
      Full Text | pdf link PDF open access
    • Factors Associated With Public Trust in Pharmaceutical Manufacturers
      JAMA Network Open
      Research
      March 14, 2023

      This cross-sectional study examines how key demographic and predisposing factors are associated with consumer trust in pharmaceutical manufacturers.

      Public Health Pharmacy and Clinical Pharmacology
      Full Text | pdf link PDF open access
    • Evaluation of Health-Related Values and Preferences of Adults Who Were Preterm Infants and Parents of Preterm Infants Concerning Use of Prophylactic Cyclooxygenase Inhibitor Drugs
      JAMA Network Open
      Research
      March 9, 2023

      This cross-sectional study explores the health-related values and preferences of adults who had been preterm infants and parents of preterm infants concerning the use of cyclo-oxygenase inhibitors in preterm infants to prevent patent ductus arteriosus–related morbidity and mortality.

      Pediatrics Surgery Neonatology Antenatal Exposures and Child Outcomes Neurosurgery
      Full Text | pdf link PDF open access
    • Evaluation of Plasmapheresis vs Immunoglobulin as First Treatment After Ineffective Systemic Corticosteroid Therapy for Patients With Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
      JAMA Dermatology
      Research
      March 8, 2023

      This retrospective cohort study evaluated the outcomes of administering plasmapheresis or intravenous immunoglobulin therapy first after ineffective systemic corticosteroid treatment among inpatients with Stevens-Johnson syndrome and toxic epidermal necrolysis in Japan.

      Dermatology Cutaneous Drug Reactions Adverse Drug Events Allergy and Clinical Immunology
      Full Text | pdf link PDF
    • Use of Leukotriene-Receptor Antagonists During Pregnancy and Risk of Neuropsychiatric Events in Offspring
      JAMA Network Open
      Research
      March 7, 2023

      This cohort study examines the association of the use of leukotriene-receptor antagonists during pregnancy with the risk of neuropsychiatric events in offspring.

      Pediatrics Antenatal Exposures and Child Outcomes Women's Health Pharmacy and Clinical Pharmacology Obstetrics and Gynecology
      Full Text | pdf link PDF open access
    • Moving the Needle to Reduce Acetaminophen (Paracetamol) Hepatotoxicity
      JAMA
      Opinion
      March 7, 2023
      Toxicology Public Health Health Policy Gastroenterology and Hepatology Hepatobiliary Disease
      Full Text | pdf link PDF has multimedia
    • Coordinated Care to Optimize Cardiovascular Preventive Therapies in Type 2 Diabetes: A Randomized Clinical Trial
      JAMA
      Research
      March 6, 2023

      This cluster randomized clinical trial assesses the effect of a coordinated, multifaceted intervention of assessment, education, and feedback vs usual care on the prescribing of all 3 groups of recommended therapies (high-intensity statins, angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, and sodium-glucose cotransporter 2 inhibitors and/or glucagon-like peptide 1 receptor agonists) for adults with type 2 diabetes and atherosclerotic cardiovascular disease.

      Diabetes Diabetes and Endocrinology Cardiovascular Risk Factors Cardiology Dyslipidemia
      Full Text | pdf link PDF
    • Treat-to-Target or High-Intensity Statin in Patients With Coronary Artery Disease: A Randomized Clinical Trial
      JAMA
      Research
      March 6, 2023

      This randomized clinical trial compares the efficacy of a treat-to-target low-density lipoprotein cholesterol (LDL-C) strategy of 50 to 70 mg/dL as the goal vs high-intensity statin therapy for the 3-year composite of death, myocardial infarction, stroke, or coronary revascularization in patients with coronary artery disease.

      Cardiology Dyslipidemia Cardiovascular Risk Factors Ischemic Heart Disease
      Full Text | pdf link PDF
    • Acute-Onset Orbital Inflammation in a Patient With Multiple Myeloma
      JAMA Ophthalmology
      Case Report
      March 2, 2023

      A 72-year-old man presented with right eye conjunctival injection, chemosis, eyelid edema, and pain with eye movements. Examination of the right eye was notable for visual acuity of 20/50, reduced ocular motility in all gazes, proptosis, and chemosis. Treatment with vancomycin and ceftriaxone and ampicillin-sulbactam was followed by a worsening in symptoms. What would you do next?

      Orbit Adverse Drug Events Clinical Challenge Hematologic Cancer Hematology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Bringing Transparency and Rigor to Medicare Drug Pricing
      JAMA Health Forum
      Opinion
      March 2, 2023

      This JAMA Forum discusses implementation of the Medicare drug pricing provision of the Inflation Reduction Act of 2022 and ways the new frameworks can be tweaked to achieve the desired public health goals.

      Health Policy Geriatrics Health Care Economics, Insurance, Payment Pharmacoeconomics
      Full Text | pdf link PDF open access
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