Explore the latest in clinical pharmacy and pharmacology, including topics in drug safety, development, pharmacogenetics, and pharmacoeconomics.
This Medical Letter review summarizes evidence about the safety and efficacy of over-the-counter melatonin-containing products as sleep aids for insomnia in children, and their role relative to standard nonpharmacological treatments.
This Viewpoint discusses how a recent US Supreme Court decision raises questions about whether an employer-based health care system can continue to best serve employees and the public at large.
This systematic review and network meta-analysis clarifies which first-line treatment is associated with the best tumor response among patients with extensive-stage small cell lung cancer (SCLC).
This secondary analysis of the AVANT trial explores the efficacy of adjuvant bevacizumab combined with oxaliplatin-based chemotherapy and disease-free survival (DFS) rates in patients with high-risk, stage II colon cancer.
This case report describes a woman in her 70s with type 2 diabetes, hypertension, idiopathic thrombocytopenia, and metastatic cholangiocarcinoma with an fibroblast growth factor receptor 2 translocation.
This JAMA Insights article proposes an algorithm to guide the choice of oral contraceptives (OCs) for individuals with hypertension given the risk of elevated blood pressure and attendant complications of hypertension with OCs.
This randomized clinical trial examines whether 6-month interventions involving different financial incentives to encourage statin adherence reduce low-density lipoprotein cholesterol levels from baseline to 12 months.
This cohort study compares definitive therapy with oral β-lactam antibiotics vs fluoroquinolones or trimethoprim-sulfamethoxazole after 1 to 5 days of parenteral antibiotics for Enterobacterales bacteremia from a suspected urine source.
This randomized clinical trial assesses the efficacy and toxicity of radiotherapy plus icotinib compared with radiotherapy alone in older patients with unresectable esophageal squamous cell carcinoma (ESCC) in China.
This cluster randomized clinical trial evaluates the effect of passive choice and active choice interventions in the electronic health record to promote guideline-directed statin therapy.
This cohort study examines the association of integrated specialty pharmacy use among members of a university hospital accountable care organization (ACO) with total medical expenditure.
This study examines the US Food and Drug Administration’s approval process for biosimilar biologic products by evaluating the site and facility inspections, animal and human studies, and comparative efficacy trials conducted to support the applications.
This Teachable Moment discusses opioid-induced constipation and preventive strategies.
This pooled analysis of data from 4 completed phase 3 randomized clinical trials assesses the efficacy and safety associated with administration of bempedoic acid vs placebo among patients with hypercholesterolemia and atherosclerotic cardiovascular disease with or without heterozygous familial hypercholesterolemia who were receiving statins and among patients with hypercholesterolemia and statin intolerance.
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