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    Clinical Pharmacy and Pharmacology

    Explore the latest in clinical pharmacy and pharmacology, including topics in drug safety, development, pharmacogenetics, and pharmacoeconomics.

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    • Perinatal Outcomes After Statin Exposure During Pregnancy
      JAMA Network Open
      Research
      December 30, 2021

      This cohort study uses data from the Taiwan National Health Insurance Research Database to examine perinatal outcomes among offspring associated with maternal use of statins during pregnancy.

      Obstetrics and Gynecology Pharmacy and Clinical Pharmacology Cardiology Dyslipidemia Cardiovascular Risk Factors
      Full Text | pdf link PDF open access
    • Self-reported Behaviors Regarding Medications to Save Money Among Sexual Minority Adults in the US, 2015-2018
      JAMA
      Research
      December 28, 2021

      This survey-based study of US adults from gender and sexual minority populations examines self-reported behaviors to save money on prescription medications, including skipping doses, purchasing from other countries, delaying refills, taking less medication, and using alternative therapies.

      Complementary and Alternative Medicine Pharmacoeconomics Pharmacoepidemiology LGBTQ
      Full Text | pdf link PDF
    • Tirzepatide Tested for Type 2 Diabetes With High Cardiovascular Risk
      JAMA
      News
      December 28, 2021
      Cardiology Diabetes Cardiovascular Risk Factors Diabetes and Endocrinology
      Full Text | pdf link PDF free
    • Contraception Selection, Effectiveness, and Adverse Effects: A Review
      JAMA
      Review
      December 28, 2021

      This Review summarizes current evidence regarding the efficacy, adverse effects, and optimal selection of reversible contraceptives, including oral contraceptive pills, intrauterine devices and subdermal implants, and condoms.

      Gynecology Women's Health Obstetrics and Gynecology
      Full Text | pdf link PDF | CME & MOC free is active quiz has multimedia
    • Expanding Access to Medication Abortions
      JAMA
      News
      December 22, 2021

      This Medical News feature examines recent developments involving medication abortions outside traditional health care channels.

      Adolescent Medicine Pediatrics Public Health Women's Health Obstetrics and Gynecology
      Full Text | pdf link PDF free
    • Analysis of COVID-19 Vaccine Type and Adverse Effects Following Vaccination
      JAMA Network Open
      Research
      December 22, 2021

      This cohort study evaluates factors potentially associated with participant-reported adverse effects after COVID-19 vaccination.

      Infectious Diseases Vaccination Public Health Pharmacy and Clinical Pharmacology Coronavirus (COVID-19)
      Full Text | pdf link PDF open access
    • Effect of Therapeutic Drug Monitoring vs Standard Therapy During Maintenance Infliximab Therapy on Disease Control in Patients With Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial
      JAMA
      Research
      December 21, 2021

      This randomized clinical trial assesses the effect of therapeutic drug monitoring vs standard therapy on sustained disease control without disease worsening among patients with immune-mediated inflammatory diseases (rheumatoid arthritis, spondyloarthritis, psoriatic arthritis, ulcerative colitis, Crohn disease, or psoriasis) undergoing maintenance therapy with infliximab.

      Rheumatoid Arthritis Rheumatology Gastroenterology and Hepatology Dermatology Gastroenterology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Assessment of the Safety of Common Medications Used During Pregnancy
      JAMA
      Review
      December 21, 2021

      This JAMA Insights in the Women’s Health series reviews commonly used prescription and over-the-counter products during pregnancy, including safety data, available resources for guidance, and the need for clinicians to counsel patients before pregnancy, when possible, about medication use.

      Women's Health Obstetrics and Gynecology Pregnancy Obstetrics Antenatal Exposures and Child Outcomes
      Full Text | pdf link PDF has multimedia
    • Therapeutic Drug Monitoring for Immune-Mediated Inflammatory Diseases
      JAMA
      Opinion
      December 21, 2021
      Inflammatory Bowel Disease Rheumatoid Arthritis Rheumatology
      Full Text | pdf link PDF
    • Supporting the Use of At-Home COVID-19 Testing
      JAMA
      News
      December 21, 2021
      Regulatory Agencies Coronavirus (COVID-19) Pathology and Laboratory Medicine
      Full Text | pdf link PDF free
    • Association of Intravenous Acetaminophen Administration With the Duration of Intravenous Opioid Use Among Hospitalized Pediatric Patients
      JAMA Network Open
      Research
      December 21, 2021

      This comparative effectiveness research study evaluates whether receipt of intravenous acetaminophen before receipt of intravenous opioid is associated with a reduction in intravenous opioid duration.

      Pediatrics Pain Medicine Pharmacy and Clinical Pharmacology Addiction Medicine Opioids
      Full Text | pdf link PDF open access
    • Effect of Concurrent Chemoradiotherapy With Nedaplatin vs Cisplatin on the Long-term Outcomes of Survival and Toxic Effects Among Patients With Stage II to IVB Nasopharyngeal Carcinoma: A 5-Year Follow-up Secondary Analysis of a Randomized Clinical Trial
      JAMA Network Open
      Research
      December 20, 2021

      This 5-year follow-up secondary analysis of a randomized clinical trial analyzed survival outcomes and late toxic effects to assess the efficacy of nedaplatin-based concurrent chemoradiotherapy in the treatment of stage II to IVB nasopharyngeal carcinoma.

      Oncology Cancer Survivorship Adverse Drug Events Pharmacy and Clinical Pharmacology Toxicology
      Full Text | pdf link PDF open access
    • Effect of Values Affirmation on Reducing Racial Differences in Adherence to Hypertension Medication: The HYVALUE Randomized Clinical Trial
      JAMA Network Open
      Research
      December 16, 2021

      This randomized clinical trial examines whether a values affirmation writing exercise improves medication adherence and whether the effect differs by patient race and ethnicity.

      Diversity, Equity, and Inclusion Cardiology Health Disparities Hypertension Cardiovascular Risk Factors
      Full Text | pdf link PDF open access
    • Association Between Antimicrobial Prophylaxis With Double-Dose Cefuroxime and Surgical Site Infections in Patients Weighing 80 kg or More
      JAMA Network Open
      Research
      December 15, 2021

      This cohort study assesses whether double-dose cefuroxime surgical antimicrobial prophylaxis was associated with the rate of surgical site infection in patients weighing at least 80 kg.

      Infectious Diseases Obesity Nutrition, Obesity, Exercise Pharmacy and Clinical Pharmacology Surgery
      Full Text | pdf link PDF open access
    • Comparative Effectiveness of Biologic Agents Among Black and White Medicare Patients in the US With Metastatic Colorectal Cancer
      JAMA Network Open
      Research
      December 15, 2021

      This comparative effectiveness analysis assesses whether the overall survival benefit of biologic drugs in White patients is similar to that for Black patients in a real-world setting using the Surveillance, Epidemiology, and End Result (SEER)–Medicare linked database.

      Oncology Health Disparities Pharmacy and Clinical Pharmacology Health Inequities Diversity, Equity, and Inclusion
      Full Text | pdf link PDF open access
    • Anticancer Drugs Approved by the US Food and Drug Administration From 2009 to 2020 According to Their Mechanism of Action
      JAMA Network Open
      Research
      December 14, 2021

      This cross-sectional study characterizes the mechanisms of action of anticancer drugs approved by the US Food and Drug Administration (FDA) between 2009 and 2020, noting how many approvals were based on a new mechanism of action vs next-in-class drugs.

      Oncology Drug Development Regulatory Agencies Health Care Economics, Insurance, Payment Pharmacoeconomics
      Full Text | pdf link PDF open access
    • Anticancer Drug Approvals in the Past Decade—Quality vs Quantity
      JAMA Network Open
      Opinion
      December 14, 2021
      Oncology Drug Development Regulatory Agencies Health Care Economics, Insurance, Payment Pharmacoeconomics
      Full Text | pdf link PDF open access
    • Characterization of the Clinical Evidence Supporting Repository Corticotropin Injection for FDA-Approved Indications: A Scoping Review
      JAMA Internal Medicine
      Review
      December 13, 2021

      This scoping review characterizes the clinical evidence supporting the use of repository corticotropin for its Food and Drug Administration–approved indications.

      Endocrinology Rheumatology Diabetes and Endocrinology Neurology
      Full Text | pdf link PDF
    • Substitution of Nonpharmacologic Therapy With Opioid Prescribing for Pain During the COVID-19 Pandemic
      JAMA Network Open
      Research
      December 10, 2021

      This cross-sectional study of claims data from 24 million US patients in a nationwide commercial insurance database assesses patterns of pain management treatment in the period before the COVID-19 pandemic vs during the COVID-19 pandemic.

      Pharmacoepidemiology Pain Medicine Pharmacy and Clinical Pharmacology Addiction Medicine Opioids
      Full Text | pdf link PDF open access
    • Trustworthy Clinical Practice Guidelines of Pharmacological Treatments for Hospitalized Patients With COVID-19—A Scarce Resource
      JAMA Network Open
      Opinion
      December 10, 2021
      Medical Journals and Publishing Pharmacy and Clinical Pharmacology Coronavirus (COVID-19) Guidelines
      Full Text | pdf link PDF open access
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