Explore the latest in endometrial cancer, including advances in understanding genetic risks for the disease and its diagnosis and management.
This cohort study examines the diagnostic accuracy, performance characteristics, and morbidity associated with sentinel lymph node biopsy in patients with intermediate- and high-grade endometrial cancer.
This open-label phase 1 study assesses the antitumor activity, tolerability, and safety of dostarlimab for patients with recurrent or advanced deficient mismatch repair endometrial cancer that has progressed after platinum-containing chemotherapy.
This diagnostic test validates a metabolomics-based classification algorithm as a screening test for endometrial carcinoma.
This qualitative study uses semistructured interviews and an adapted health belief model to describe the beliefs, interpretations, and experiences of symptom onset, symptom disclosure, and diagnosis among black women with endometrial cancer.
This phase 3 randomized clinical trial evaluates the clinical benefit of taxane plus platinum regimens compared with standard doxorubicin plus cisplatin in postoperative adjuvant chemotherapy for endometrial cancer.
This cohort study evaluates the association between the nationwide introduction of minimally invasive robotic surgery in Denmark and severe complications in patients with early-stage endometrial cancer.
This systematic review and meta-analysis assesses the prevalence of postmenopausal bleeding among women with endometrial cancer and the risk of endometrial cancer in women with postmenopausal bleeding.
This population-based study evaluates the risk of cancer in families who are positive for Amsterdam criteria for Lynch syndrome.
This randomized clinical trial compares the effects on disease-free survival of total laparoscopic vs abdominal hysterectomy among women with stage I endometrial cancer treated at tertiary gynecological cancer centers in Australia, New Zealand, and Hong Kong.
This Clinical Evidence Synopsis summarizes a Cochrane review that analyzes the association between lymphadenectomy and survival, disease recurrence, and surgical morbidity in women with presumed early-stage, low-grade endometrial carcinoma.
This multicenter cohort study accesses the risk for uterine cancer and distribution of specific histologic subtypes after risk-reducing salpingo-oophorectomy without hysterectomy among women with BRCA mutations.
A 43-year-old woman with stage IA endometrial cancer had her tumor screened for DNA mismatch repair proteins and microsatellite instability and had 1 absent immunostain. How do you interpret the test results?
This genetic sequencing study investigated whether endometrial cancers with polymerase e mutations and microsatellite instability had increased neoantigen load, more tumor-infiltrating lymphocytes, and higher expression of PD-1 and PD-L1 than endometrial cancers without these characteristics.
This Ophthalmic Image describes a dislocated crystalline lens that erroneously mimicked metastatic cancer as a complication of homocystinuria.
Using colon cancer registry data, these investigators found that in women with a mismatch repair gene mutation, hormonal factors such as age at menarche, parity, and use of hormonal contraceptives were associated with a lower risk of endometrial cancer.
Manson and coauthors provide an update and overview of health outcomes during the intervention and poststopping phases of the Women’s Health Initiative (WHI) hormone therapy trials. In an accompanying Editorial, Nabel discusses how the WHI is a victory for women and their health.
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