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    Epilepsy and Seizures

    Explore the latest in epilepsy and seizures, including the epidemiology, etiology, diagnosis and management of seizure disorders.

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    • Comparison of Perinatal Outcomes for Women With and Without Epilepsy: A Systematic Review and Meta-analysis
      JAMA Neurology
      Research
      March 13, 2023

      This systematic review and meta-analysis compares data for women with and without epilepsy to investigate maternal, fetal, and neonatal complications and their associations with epilepsy and use of antiseizure medications.

      Neurology Women's Health Neonatology Pediatrics Pregnancy
      Full Text | pdf link PDF
    • Efficacy and Safety of Dietary Therapies for Childhood Drug-Resistant Epilepsy: A Systematic Review and Network Meta-analysis
      JAMA Pediatrics
      Research
      March 1, 2023

      This systematic review and network meta-analysis evaluates the comparative efficacy and safety of various dietary therapies in childhood drug-resistant epilepsy.

      Diet Neurology Pediatrics
      Full Text | pdf link PDF
    • Magnetic Resonance Imaging Features of GABA-A Receptor Antibody-Mediated Encephalitis
      JAMA Neurology
      Case Report
      February 6, 2023

      This case report describes a patient with status epilepticus and neuroimaging features of fleeting T2 fluid-attenuated inversion recovery hyperintense lesions on magnetic resonance imaging.

      Neurology Inflammatory CNS Disorders Radiology Neuroimaging Images in Neurology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Widening the Spectrum of Risk Factors, Comorbidities, and Prodromal Features of Parkinson Disease
      JAMA Neurology
      Research
      February 1, 2023

      This case-control study investigates the risk factors, comorbidities, and prodromal symptoms associated with a diagnosis of Parkinson disease in a large representative database.

      Movement Disorders Neurology Parkinson Disease Sleep Medicine Tremor
      Full Text | pdf link PDF open access
    • Association Between Antiepileptic Drugs and Incident Parkinson Disease
      JAMA Neurology
      Research
      February 1, 2023

      This case-control study investigates the association between antiepileptic drugs and incident Parkinson disease.

      Neurology Pharmacoepidemiology Movement Disorders Parkinson Disease
      Full Text | pdf link PDF
    • Laryngology Outcomes Following Implantable Vagus Nerve Stimulation
      JAMA Otolaryngology–Head & Neck Surgery
      Research
      January 1, 2023

      This cross-sectional study examines trends in laryngeal complications reported to the US Food and Drug Administration after vagus nerve stimulation implantation.

      Laryngology Medical Devices and Equipment Neurology Otolaryngology Psychiatry and Behavioral Health
      Full Text | pdf link PDF
    • Losartan Decreases Incidence of Epilepsy in Arterial Hypertension
      JAMA
      News
      December 6, 2022
      Clinical Pharmacy and Pharmacology Hypertension Pharmacoepidemiology Neurology
      Full Text | pdf link PDF
    • Tackling the Unmet Therapeutic Needs in Nonsurgical Treatments for Epilepsy
      JAMA Neurology
      Opinion
      December 1, 2022

      This Viewpoint discusses unmet therapeutic needs among patients with epilepsy and evaluates the trajectory of treatment development.

      Neurology
      Full Text | pdf link PDF
    • Association Between Angiotensin Receptor Blocker Therapy and Incidence of Epilepsy in Patients With Hypertension
      JAMA Neurology
      Research
      December 1, 2022

      This cohort study assesses whether the use of angiotensin receptor blocker therapy is associated with a reduced incidence of epilepsy in patients with hypertension.

      Hypertension Neurology
      Full Text | pdf link PDF
    • Genetic Testing to Inform Epilepsy Treatment Management From an International Study of Clinical Practice
      JAMA Neurology
      Research
      December 1, 2022

      This cross-sectional study investigates if genetic diagnoses in patients with epilepsy are associated with changes in clinical management and subsequent outcomes.

      Genetics and Genomics Neurogenetics Neurology
      Full Text | pdf link PDF open access
    • Genetic Testing in Patients With Epilepsy May Impact Treatments and Improve Outcomes
      JAMA Neurology
      Opinion
      December 1, 2022
      Genetics and Genomics Neurogenetics Neurology
      Full Text | pdf link PDF
    • New and Progressive Medical Conditions After Pediatric Sepsis Hospitalization Requiring Critical Care
      JAMA Pediatrics
      Research
      November 7, 2022

      This cohort study uses a national administrative claims database of children with sepsis or nonsepsis hospitalization to assess whether sepsis is associated with the development and progression of comorbid conditions.

      Infectious Diseases Nutrition Sepsis Pediatrics Resuscitation
      Full Text | pdf link PDF
    • Threats to Evidence-Based Care With Teratogenic Medications in States With Abortion Restrictions
      JAMA
      News
      November 1, 2022

      This Medical News article discusses how abortion bans could affect patients for whom teratogenic drugs are the standard of care.

      Acne Congenital Defects Dermatology Clinical Pharmacy and Pharmacology Neurology
      Full Text | pdf link PDF has multimedia
    • Cancer Risk in Children of Mothers With Epilepsy and High-Dose Folic Acid Use During Pregnancy
      JAMA Neurology
      Research
      November 1, 2022

      This cohort study uses nationwide register data from 3 Nordic countries to examine the association between risk of childhood cancer and high-dose folic acid supplementation in mothers with epilepsy.

      Neurology Antenatal Exposures and Child Outcomes Women's Health Obstetrics Pediatrics
      Full Text | pdf link PDF open access has multimedia
    • Development and Validation of a Deep Learning Model for Predicting Treatment Response in Patients With Newly Diagnosed Epilepsy
      JAMA Neurology
      Research
      October 1, 2022

      This cohort study tests a deep learning model using readily available clinical information to predict treatment success with the first antiseizure medication for individual patients.

      Health Informatics Neurology
      Full Text | pdf link PDF
    • Choosing the Best Antiseizure Medication—Can Artificial Intelligence Help?
      JAMA Neurology
      Opinion
      October 1, 2022
      Neurology Health Informatics
      Full Text | pdf link PDF
    • Association Between Standardized Mortality Ratio and Utilization of Care in US Veterans With Drug-Resistant Epilepsy Compared With All US Veterans and the US General Population
      JAMA Neurology
      Research
      September 1, 2022

      This cohort study evaluates associations between mortality and health care utilization among US veterans with drug-resistant epilepsy.

      Neurology Veterans Health
      Full Text | pdf link PDF
    • Focal Cooling for Drug-Resistant Epilepsy: A Review
      JAMA Neurology
      Review
      September 1, 2022

      This narrative review presents the most current evidence supporting focal cooling in epilepsy and offers a brief overview of the technical challenges related to focal cooling in humans, including the optimal device design and cooling parameters.

      Neurology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Adjunctive Transdermal Cannabidiol for Adults With Focal Epilepsy: A Randomized Clinical Trial
      JAMA Network Open
      Research
      July 8, 2022

      This randomized clinical trial evaluates the use of transdermal cannabidiol vs placebo for adults with drug-resistant focal epilepsy.

      Neurology Substance Use and Addiction Medicine Drug Development
      Full Text | pdf link PDF open access
    • Association of Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability
      JAMA Neurology
      Research
      July 1, 2022

      This cohort study evaluates whether children exposed prenatally to antiseizure medications in mono- and duotherapy have increased risk of neurodevelopmental disorders.

      Neurology Women's Health Obstetrics and Gynecology Pregnancy Obstetrics
      Full Text | pdf link PDF open access has multimedia
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