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    Esophageal Disease

    Explore the latest in esophageal disease, including motility disorders, diagnosis, and management of Barrett’s esophagus and esophageal cancer.

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    • Effectiveness of S-1–Based Chemoradiotherapy in Patients 70 Years and Older With Esophageal Squamous Cell Carcinoma: A Randomized Clinical Trial
      JAMA Network Open
      Research
      May 17, 2023

      This randomized clinical trial compares the efficacy and safety of simultaneous integrated boost radiotherapy with concurrent and consolidated oral S-1 chemotherapy vs radiotherapy alone for patients aged 70 years and older with inoperable esophageal squamous cell carcinoma.

      Oncology Gastroenterology Gastroenterology and Hepatology Esophageal Cancer Gastrointestinal Cancer
      Full Text | pdf link PDF open access
    • Association of Radiotherapy Duration With Clinical Outcomes in Patients With Esophageal Cancer Treated in NRG Oncology Trials: A Secondary Analysis of NRG Oncology Randomized Clinical Trials
      JAMA Network Open
      Research
      April 21, 2023

      This secondary analysis examines the local-regional failure, distant failure, disease-free survival, and overall survival in patients with esophageal cancer who underwent definitive chemoradiotherapy during NRG Oncology randomized clinical trials.

      Oncology Radiation Oncology Gastroenterology and Hepatology Esophageal Cancer Gastroenterology
      Full Text | pdf link PDF open access
    • Does Bariatric Surgery Increase the Risk of Gastroesophageal Cancer?
      JAMA Surgery
      Opinion
      March 1, 2023
      Bariatric Surgery Obesity Oncology Surgery Cancer Epidemiology
      Full Text | pdf link PDF
    • Risk of Esophageal and Gastric Cancer After Bariatric Surgery
      JAMA Surgery
      Research
      March 1, 2023

      This cohort study examines the association of esophagogastric cancer with bariatric surgery in a large national cohort.

      Bariatric Surgery Oncology Surgery Cancer Epidemiology Gastroenterology and Hepatology
      Full Text | pdf link PDF
    • Effectiveness of Immune Checkpoint Inhibitors in Patients With Advanced Esophageal Squamous Cell Carcinoma: A Meta-analysis Including Low PD-L1 Subgroups
      JAMA Oncology
      Research
      February 1, 2023

      This meta-analysis examines whether immunotherapy confers a survival benefit for patients with advanced esophageal squamous cell carcinoma and low expression of PD-L1.

      Esophageal Cancer Gastroenterology Gastrointestinal Cancer Targeted and Immune Cancer Therapy Surgery
      Full Text | pdf link PDF open access
    • Development and Validation of Esophageal Squamous Cell Carcinoma Risk Prediction Models Based on an Endoscopic Screening Program
      JAMA Network Open
      Research
      January 26, 2023

      This diagnostic study establishes and validates esophageal squamous cell cancer prediction models for the follow-up stage of esophageal cancer screening and optimization of the esophageal cancer screening program.

      Oncology Surgery Surgical Oncology Gastroenterology and Hepatology Cancer Screening, Prevention, Control
      Full Text | pdf link PDF open access
    • Association of Sialic Acid–Binding Immunoglobulin-Like Lectin 15 With Phenotypes in Esophageal Squamous Cell Carcinoma in the Setting of Neoadjuvant Chemoradiotherapy
      JAMA Network Open
      Research
      January 17, 2023

      This cohort study explores the expression pattern and association of sialic acid–binding immunoglobulin-like lectin 15 (Siglec-15) with outcomes among patients with esophageal squamous cell carcinoma (ESCC) who received neoadjuvant chemoradiotherapy.

      Oncology Genetics and Genomics Targeted and Immune Cancer Therapy Cancer Biomarkers Surgery
      Full Text | pdf link PDF open access
    • Long-term Incidence Rates of Esophageal Squamous Cell Carcinoma in Chinese Patients With Low-grade Intraepithelial Neoplasia and Association of Surveillance Endoscopy With Incidence
      JAMA Network Open
      Research
      December 19, 2022

      This cohort study examines the incidence of esophageal squamous cell carcinoma (ESCC) and the use of surveillance endoscopy in patients with low-grade intraepithelial neoplasia in China.

      Gastroenterology and Hepatology Oncology Surgery Surgical Oncology Cancer Screening, Prevention, Control
      Full Text | pdf link PDF open access
    • Real-time Tracking and Classification of Tumor and Nontumor Tissue in Upper Gastrointestinal Cancers Using Diffuse Reflectance Spectroscopy for Resection Margin Assessment
      JAMA Surgery
      Research
      November 9, 2022

      This validation study evaluates whether diffuse reflectance spectroscopy on gastric and esophageal cancer specimens can differentiate tissue types and provide real-time feedback to the operator.

      Oncology Surgical Oncology Pathology and Laboratory Medicine Gastroenterology and Hepatology Gastric Cancer
      Full Text | pdf link PDF open access
    • Evaluation of Clinical and Safety Outcomes of Neoadjuvant Immunotherapy Combined With Chemotherapy for Patients With Resectable Esophageal Cancer: A Systematic Review and Meta-analysis
      JAMA Network Open
      Research
      November 2, 2022

      This systematic review and meta-analysis examines recent or ongoing nonrandomized clinical trials involving patients with esophageal cancer who received immune checkpoint inhibitors with or without other therapies.

      Oncology Surgery Surgical Oncology Cancer Genetics Gastroenterology and Hepatology
      Full Text | pdf link PDF open access
    • Same-Day Home Recovery for Benign Foregut Surgery
      JAMA Surgery
      Research
      November 1, 2022

      This cohort study analyzes data collected prospectively for 3 benign foregut procedures performed in 19 medical centers to determine whether same-day home recovery is feasible, safe, and effective.

      Perioperative Care and Consultation Surgery Gastrointestinal Surgery Gastroenterology Gastroesophageal Reflux
      Full Text | pdf link PDF
    • Same-Day Home Recovery After Surgery for Benign Esophageal Diseases—Is It Really Good for Patients?
      JAMA Surgery
      Opinion
      November 1, 2022
      Gastroenterology Gastrointestinal Surgery Surgery Gastroenterology and Hepatology
      Full Text | pdf link PDF
    • Association of PD-L1 Expression and Other Variables With Benefit From Immune Checkpoint Inhibition in Advanced Gastroesophageal Cancer: Systematic Review and Meta-analysis of 17 Phase 3 Randomized Clinical Trials
      JAMA Oncology
      Research
      October 1, 2022

      This systematic review and meta-analysis examines the predictive value of tissue-based PD-L1 status compared with other variables for ICI benefit among 17 randomized clinical trials including 11 166 patients with advanced gastroesophageal cancer.

      Cancer Biomarkers Esophageal Cancer Gastroenterology Gastrointestinal Cancer Genetics and Genomics
      Full Text | pdf link PDF
    • Outcomes and Molecular Features of Brain Metastasis in Gastroesophageal Adenocarcinoma
      JAMA Network Open
      Research
      August 24, 2022

      This cohort study characterizes the clinical and genomic features of patients with brain metastasis from gastroesophageal adenocarcinoma and evaluates the associations of surgical resection and radiotherapy use with survival.

      Oncology Genetics and Genomics Neuro-oncology Neurology Cancer Biomarkers
      Full Text | pdf link PDF open access
    • Barrett Esophagus: A Review
      JAMA
      Review
      August 16, 2022

      This review summarizes the current evidence regarding diagnosis and management of Barrett esophagus, including how to evaluate patients for Barrett esophagus, the association with gastroesophageal reflux disease, and progression to esophageal adenocarcinoma.

      Gastroenterology Gastroenterology and Hepatology Esophageal Cancer Gastrointestinal Cancer Oncology
      Full Text | pdf link PDF | CME & MOC is active quiz has multimedia
    • AIO INTEGA Provides Further Support for Immunotherapy in Patients With Advanced ERBB2 -Positive Gastroesophageal Adenocarcinoma
      JAMA Oncology
      Opinion
      August 1, 2022
      Targeted and Immune Cancer Therapy Oncology Gastric Cancer Gastroenterology and Hepatology Esophageal Cancer
      Full Text | pdf link PDF
    • Effect of Laparoscopic Sleeve Gastrectomy vs Roux-en-Y Gastric Bypass on Weight Loss, Comorbidities, and Reflux at 10 Years in Adult Patients With Obesity: The SLEEVEPASS Randomized Clinical Trial
      JAMA Surgery
      Research
      August 1, 2022

      This follow-up of a randomized clinical trial evaluates long-term weight loss and remission of obesity-related conditions 10 years after laparoscopic sleeve gastrectomy and laparoscopic Roux-en-Y gastric bypass.

      Obesity Surgery Gastrointestinal Surgery Gastroesophageal Reflux Bariatric Surgery
      Full Text | pdf link PDF free
    • Efficacy of Ipilimumab vs FOLFOX in Combination With Nivolumab and Trastuzumab in Patients With Previously Untreated ERBB2 -Positive Esophagogastric Adenocarcinoma: The AIO INTEGA Randomized Clinical Trial
      JAMA Oncology
      Research
      August 1, 2022

      This randomized clinical trial investigates the efficacy of trastuzumab and PD-1 inhibitor with CTLA-4 inhibitor or FOLFOX in first-line treatment of advanced ERBB2-positive esophagogastric adenocarcinoma.

      Oncology Gastric Cancer Gastroenterology and Hepatology Esophageal Cancer Gastroenterology
      Full Text | pdf link PDF free
    • Per-Oral Endoscopic Myotomy Has a Role in the Treatment Algorithm of Esophageal Achalasia
      JAMA Surgery
      Opinion
      June 1, 2022
      Gastroenterology Gastroesophageal Reflux Surgery Gastroenterology and Hepatology Swallowing and Dysphagia
      Full Text | pdf link PDF
    • Use and Safety of Per-Oral Endoscopic Myotomy for Achalasia in the US
      JAMA Surgery
      Research
      June 1, 2022

      This cohort study investigates the use, safety, and costs associated with the use of per-oral endoscopic myotomy for achalasia in the US.

      Gastroenterology Gastroesophageal Reflux Gastroenterology and Hepatology Swallowing and Dysphagia Gastrointestinal Surgery
      Full Text | pdf link PDF free
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