Explore the latest in fungal infections from The JAMA Network, including recent advances in diagnosis and treatment of cutaneous and systemic infection.
A man in his 40s presented with enlarging, nonpainful upper extremity nodules developing over the preceding 9 months; he was renovating a commercial cannabis grow house in California at time of onset and described the construction site as being filled with intoxicating mold. What is your diagnosis?
This retrospective medical record review examines the prevalence of laboratory monitoring and laboratory abnormalities during systemic terbinafine therapy in pediatric onychomycosis.
This study examines changes in practice patterns for fungal keratitis.
This analysis assesses the incidence of Pneumocystis pneumonia in patients with autoimmune blistering diseases receiving no routine prophylaxis.
This study determines whether eye bank–processed endothelial keratoplasty tissue is at higher risk of contamination than unprocessed tissue.
A 67-year-old man with granulomatous polyangiitis treated with prednisone and azathioprine has a positive galactomannan enzyme immunoassay and fungal cultures positive for Aspergillus fumigatus in bronchoalveolar lavage fluid obtained for evaluation of dyspnea and a cavitary pulmonary nodule. How would you interpret the test results?
This secondary analysis of the Mycotic Ulcer Treatment Trial II explores the development of corneal perforation and the need to undergo therapeutic penetrating keratoplasty among participants enrolled in the trial.
This secondary analysis of a randomized clinical trial explores the role of adjuvant oral voriconazole on clinical outcomes in Fusarium keratitis.
A 30-year-old man was referred with progressive quadriplegia that started from the right lower limb and gradually spread to the upper limb and contralateral side. Cerebrospinal fluid testing revealed pleocytosis, elevated protein concentration, and a decreased glucose level, and magnetic resonance imaging of the cervical spine revealed multiple intramedullary lesions. What is your diagnosis?
A woman in her 50s had right orbital pain for 3 months and her medical history was noncontributory. What would you do next?
This case report describes the process of determining which pathogen caused a woman in her 60s to present with symptoms of chronic meningitis.
This Clinical Evidence Synopsis summarizes a 2016 update of a Cochrane review of clinical trials comparing the effects of antifungal drugs on prevention of mortality and invasive fungal infection in critically ill patients without neutropenia.
This randomized clinical trial investigates the effect of oral voriconazole vs placebo in addition to topical antifungals for treatment of patients in India and Nepal with severe filamentous fungal keratitis.
A man in his 60s presented with reduced visual acuity in his right eye and had vitritis, mild optic disc edema, scattered elevated white chorioretinal lesions, and a prominent macular lesion on examination following several urologic procedures. What would you do next?
This randomized clinical trial compares the effects of micafungin vs placebo on 28-day fungal infection–free survival among nonneutropenic critically ill patients with ICU-acquired sepsis, Candida species colonization at multiple sites, and multiple organ failure.