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    Gastroenterology

    Explore the latest in gastroenterology, including topics in GI reflux, cancer, and management of inflammatory bowel and pancreatic disease.

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    • Treatment With Liposomal Irinotecan Plus Fluorouracil and Leucovorin for Patients With Previously Treated Metastatic Biliary Tract Cancer: The Phase 2b NIFTY Randomized Clinical Trial
      JAMA Oncology
      Research
      March 23, 2023

      This randomized clinical trial examines the addition of treatment with liposomal irinotecan to fluorouracil and leucovorin for patients with advanced biliary tract cancer.

      Hepatobiliary Disease Gastroenterology and Hepatology Gastrointestinal Cancer Hepatobiliary Cancer Oncology
      Full Text | pdf link PDF
    • Prevalence and Clinicopathologic Characteristics of Hypercalcemia in Patients With Cholangiocarcinoma
      JAMA Oncology
      Research
      March 23, 2023

      This cohort study investigates clinicopathologic and prognostic associations of hypercalcemia in patients with intrahepatic or extrahepatic cholangiocarcinoma.

      Acid Base, Electrolytes, Fluids Cancer Biomarkers Genetics and Genomics Cancer Genetics Hepatobiliary Disease
      Full Text | pdf link PDF
    • Patients With Normal Gut Biopsy Still at Increased Risk of IBD
      JAMA
      News
      March 21, 2023
      Inflammatory Bowel Disease Gastroenterology and Hepatology Pathology and Laboratory Medicine
      Full Text | pdf link PDF free
    • Is a Prognostic Nomogram for Complete Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Pseudomyxoma Peritonei Useful?
      JAMA Surgery
      Opinion
      March 15, 2023
      Gastrointestinal Cancer Surgery Surgical Oncology Gastroenterology and Hepatology Oncology
      Full Text | pdf link PDF
    • Laparoscopic Gastrectomy for Gastric Cancer
      JAMA Surgery
      Opinion
      March 15, 2023
      Minimally Invasive Surgery Oncology Gastric Cancer Surgery Surgical Oncology
      Full Text | pdf link PDF
    • Development and Validation of Nomograms to Predict Survival in Patients Undergoing Complete Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy for Pseudomyxoma Peritonei of Appendiceal Origin
      JAMA Surgery
      Research
      March 15, 2023

      This study attempts to evaluate the significance of clinically important variables and generate validated nomograms to predict overall and disease-free survival following complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for pseudomyxoma peritonei of appendiceal origin.

      Gastrointestinal Cancer Surgery Surgical Oncology Gastroenterology and Hepatology Oncology
      Full Text | pdf link PDF
    • Five-Year Survival Outcomes of Laparoscopy-Assisted vs Open Distal Gastrectomy for Advanced Gastric Cancer: The JLSSG0901 Randomized Clinical Trial
      JAMA Surgery
      Research
      March 15, 2023

      This randomized clinical trial investigates the 5-year survival outcomes of laparoscopy-assisted distal gastrectomy compared with open distal gastrectomy for the management of advanced gastric cancer.

      Gastrointestinal Surgery Oncology Surgery Surgical Oncology Minimally Invasive Surgery
      Full Text | pdf link PDF
    • Pathologist Validation of a Machine Learning–Derived Feature for Colon Cancer Risk Stratification
      JAMA Network Open
      Research
      March 14, 2023

      This prognostic study evaluates whether pathologist scoring of a histopathologic feature previously identified by machine learning is associated with survival among patients with colon cancer.

      Pathology and Laboratory Medicine Health Informatics Colorectal Cancer Gastrointestinal Cancer Oncology
      Full Text | pdf link PDF open access
    • Stool-Based Screening Tests for Colorectal Cancer
      JAMA
      Case Report
      March 14, 2023

      A 56-year-old man with no significant medical history has declined screening colonoscopy at previous physician visits but wants to undergo a less invasive test because his father died of colorectal cancer at age 80. What would you do next?

      Cancer Screening, Prevention, Control Colorectal Cancer Gastrointestinal Cancer Oncology Gastroenterology and Hepatology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Computer-Estimated Heart Rate vs True Heart Rate—Be Aware of the Software
      JAMA Internal Medicine
      Case Report
      March 13, 2023

      This case report describes a patient in their 60s with gastrointestinal bleeding and shock with heart rate overcounting by software indicating severe hyperkalemia.

      Critical Care Medicine Emergency Medicine Challenges in Clinical Electrocardiography Resuscitation Acid Base, Electrolytes, Fluids
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Association of Life Expectancy With Surveillance Colonoscopy Findings and Follow-up Recommendations in Older Adults
      JAMA Internal Medicine
      Research
      March 13, 2023

      This cohort study examines the association of estimated life expectancy with colonoscopy findings and recommendations for surveillance colonoscopy among adults older than 65 years in New Hampshire.

      Cancer Screening, Prevention, Control Cancer Epidemiology Geriatrics Gastroenterology and Hepatology Colorectal Cancer
      Full Text | pdf link PDF
    • Virtually Grounded
      JAMA
      Opinion
      March 9, 2023

      In this narrative essay, an emergency medicine physician who is undergoing treatment for stage IV colorectal cancer discusses the role that virtual reality might play in end-of-life care in the future to help patients virtually travel the world and connect with others.

      Humanities Narrative Medicine End of Life A Piece of My Mind Gastroenterology and Hepatology
      Full Text | pdf link PDF free
    • Immunotherapy Success for Microsatellite Stable Colorectal Cancers—Searching for the Horizon
      JAMA Oncology
      Opinion
      March 9, 2023
      Colorectal Cancer Gastrointestinal Cancer Targeted and Immune Cancer Therapy Oncology Gastroenterology and Hepatology
      Full Text | pdf link PDF
    • Regorafenib, Ipilimumab, and Nivolumab for Patients With Microsatellite Stable Colorectal Cancer and Disease Progression With Prior Chemotherapy: A Phase 1 Nonrandomized Clinical Trial
      JAMA Oncology
      Research
      March 9, 2023

      This nonrandomized clinical trial assesses the recommended phase 2 dose of regorafenib, ipilimumab, and nivolumab immunotherapy for patients with refractory microsatellite stable metastatic colorectal cancer.

      Colorectal Cancer Gastrointestinal Cancer Targeted and Immune Cancer Therapy Oncology Gastroenterology and Hepatology
      Full Text | pdf link PDF
    • Patient and Hospital Characteristics Associated With Delayed Diagnosis of Appendicitis
      JAMA Surgery
      Research
      March 8, 2023

      This cohort study examines the association of race and ethnicity with delayed diagnosis of appendicitis and length of hospital stay and rate of 30-day hospital readmissions after appendectomy among adult patients in the US.

      Gastrointestinal Surgery Health Disparities Surgery Health Inequities Health Care Safety
      Full Text | pdf link PDF
    • Effect of Induction Therapy With Olamkicept vs Placebo on Clinical Response in Patients With Active Ulcerative Colitis: A Randomized Clinical Trial
      JAMA
      Research
      March 7, 2023

      This randomized clinical trial compares clinical response at 12 weeks with olamkicept vs placebo in treating adult patients with active ulcerative colitis.

      Inflammatory Bowel Disease Gastroenterology and Hepatology
      Full Text | pdf link PDF
    • Association of BRAF Variants With Disease Characteristics, Prognosis, and Targeted Therapy Response in Intrahepatic Cholangiocarcinoma
      JAMA Network Open
      Research
      March 3, 2023

      This cohort study examines BRAF variant subtypes, classifying them and analyzing response to therapy in patients with intrahepatic cholangiocarcinoma.

      Oncology Cancer Genetics Hepatobiliary Disease Gastroenterology and Hepatology Genetics and Genomics
      Full Text | pdf link PDF open access
    • Trends and Racial and Geographic Differences in Infant Mortality in the United States Due to Necrotizing Enterocolitis, 1999 to 2020
      JAMA Network Open
      Research
      March 3, 2023

      This cohort study analyzes yearly trends in necrotizing enterocolitis–related infant mortality rates (NEC-IMR) from 1999 to 2020, overall and by Black and White race, and described Black-to-White NEC-IMR ratios and NEC-IMR for US states.

      Pediatrics Gastroenterology and Hepatology Infectious Diseases Neonatology
      Full Text | pdf link PDF open access
    • Socioeconomic and Geographic Disparities in the Referral and Treatment of Pancreatic Cancer at High-Volume Centers
      JAMA Surgery
      Research
      March 1, 2023

      This study attempts to evaluate how referral, treatment, and outcomes for patients with pancreatic adenocarcinoma vary by socioeconomic status and geography.

      Gastrointestinal Cancer Health Disparities Oncology Pancreatic Cancer Surgery
      Full Text | pdf link PDF
    • Calling Out Disparities in Pancreatic Cancer Care
      JAMA Surgery
      Opinion
      March 1, 2023
      Oncology Pancreatic Cancer Pancreatic Disease Gastroenterology and Hepatology Health Inequities
      Full Text | pdf link PDF
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