Explore the latest in gastroesophageal reflux, including diagnosis, treatment, prevention, and systemic manifestations in children and adults.
This cohort study of patients from the 5 Nordic countries examines whether gastroesophageal antireflux surgery is associated with decreased risk of esophageal adenocarcinoma and whether surgically and medically treated patients experience different outcomes.
A 22-year-old man with a 10-year history of gastroesophageal reflux disease (GERD)–like symptoms and taking 20 mg/d of omeprazole had a normal esophagogastroduodenoscopy (EGD) and was diagnosed with achalasia following a high-resolution manometry (HRM) study. What would you do next?
This Clinical Guidline Synopsis from the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) introduces updated guidelines for the treatment of gastroesophageal reflux in infants and children.
This Viewpoint discusses proton pump inhibitor use and outcomes among children without gastroesophageal reflux in light of the growing body of adult and pediatric literature highlighting the association of proton pump inhibitor use with the risk of fractures, infections, renal disease, cardiac disease, and even death.
This cohort study examines the association between development of childhood allergies and use of histamine-2 receptor antagonists, proton pump inhibitors, or antibiotics during infancy.
This JAMA Clinical Guidelines Synopsis summarizes the 2017 American College of Gastroenterology and Canadian Association of Gastroenterology guideline on management of dyspepsia.
This population-based analysis examines the association between surgical volume and postoperative results in patients with esophageal achalasia who underwent esophagomyotomy.
A 56-year-old woman with persistent GERD symptoms on 40 mg esomeprazole had a normal EGD and 24-hour ambulatory reflux monitoring results. What would you do next?
This case-control study uses a database of population-based tumor registries to investigate the association of gastroesophageal reflux disease with the risk of malignancy in the upper aerodigestive tract in elderly patients.
This trainee-led quality improvement study evaluates the use of the Culture, Oversight, Systems Change, Training framework to reduce inappropriate proton pump inhibitor infusions in patients with upper gastrointestinal bleeding.
This Medical News article examines the use of stomach acid suppressors to treat mild gastric reflux in infants.
This cohort study examines the efficacy of a dietary approach to treating laryngopharyngeal reflux using alkaline water, a plant-based, Mediterranean-style diet, and standard reflux precautions compared with the traditional treatment approach using proton pump inhibition.
This Medical Letter review summarizes safety concerns regarding proton pump inhibitors such as increased fracture risk, hypomagnesemia and QT prolongation, and acute interstitial nephritis.
This cohort study assesses the risk of recurrence of gastroesophageal reflux after laparoscopic antireflux surgery and risk factors for reflux recurrence.
This study discusses magnetic sphincter augmentation as an option for patients at a single tertiary referral center.
This secondary analysis of the TRIO-013 phase 3 randomized clinical trial attempts to determine if gastric acid suppressants such as proton pump inhibitors may impair capecitabine efficacy.
This cross-sectional analysis uses data from the National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey to determine whether chronic rhinosinusitis is associated with administration of antireflux medications.
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