Explore the latest in gastroesophageal reflux, including diagnosis, treatment, prevention, and systemic manifestations in children and adults.
This Teachable Moment examines the case of a man in his 70s who presented to the emergency department 2 weeks after discontinuation of proton pump inhibitors (PPIs) to caution against abrupt PPI discontinuation in patients with multiple risk factors for peptic ulcer disease.
This randomized clinical trial compares the effects on symptoms and recurrence of peroral endoscopic myotomy (POEM) vs pneumatic dilation for the initial treatment of idiopathic achalasia.
This systematic review examines whether fundoplication is effective control of signs and symptoms in adults with laryngopharyngeal reflux.
This randomized clinical trial attempts to determine whether partial or total fundoplication is superior for treating gastroesophageal reflux disease.
This Clinical Guideline Synopsis discusses the 2018 Pediatric Gastroesophageal Reflux Clinical Practice Guidelines: Joint Recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN).
This pharmacoepidemiology study examines the association between oral anticoagulants (warfarin, apixaban, dabigatran, and rivaroxaban), cotherapy with proton pump inhibitors (PPIs), and upper gastrointestinal (UGI) tract bleeding in Medicare beneficiaries.
This essay discusses the benefits and risks of gastric bypass vs sleeve gastrectomy for inducing weight loss among individuals with morbid obesity with or without gastroesophageal reflux disease.
This retrospective cohort study of 293 children with oropharyngeal dysphagia examines hospitalization risk for those treated with proton pump inhibitors compared with those who were not.
This cohort study of patients from the 5 Nordic countries examines whether gastroesophageal antireflux surgery is associated with decreased risk of esophageal adenocarcinoma and whether surgically and medically treated patients experience different outcomes.
A 22-year-old man with a 10-year history of gastroesophageal reflux disease (GERD)–like symptoms and taking 20 mg/d of omeprazole had a normal esophagogastroduodenoscopy (EGD) and was diagnosed with achalasia following a high-resolution manometry (HRM) study. What would you do next?
This Clinical Guidline Synopsis from the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) introduces updated guidelines for the treatment of gastroesophageal reflux in infants and children.
This Viewpoint discusses proton pump inhibitor use and outcomes among children without gastroesophageal reflux in light of the growing body of adult and pediatric literature highlighting the association of proton pump inhibitor use with the risk of fractures, infections, renal disease, cardiac disease, and even death.
This cohort study examines the association between development of childhood allergies and use of histamine-2 receptor antagonists, proton pump inhibitors, or antibiotics during infancy.
This JAMA Clinical Guidelines Synopsis summarizes the 2017 American College of Gastroenterology and Canadian Association of Gastroenterology guideline on management of dyspepsia.
This population-based analysis examines the association between surgical volume and postoperative results in patients with esophageal achalasia who underwent esophagomyotomy.
A 56-year-old woman with persistent GERD symptoms on 40 mg esomeprazole had a normal EGD and 24-hour ambulatory reflux monitoring results. What would you do next?
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