Explore the latest in hematology, including topics in anticoagulation, bleeding and transfusion, hematologic cancers, and more.
This narrative review discusses the pathophysiology, clinical presentation, and diagnosis, and staging of chronic lymphocytic leukemia and summarizes current treatments.
This systematic review with meta-analysis examines the regulatory oversight of the accelerated approval pathway and evidence generation for idelalisib during premarketing, postmarketing, and premarketing withdrawal periods.
This nonrandomized clinical trial investigates the addition of pembrolizumab to ifosfamide, carboplatin, and etoposide chemotherapy and evaluates the response rate of patients with relapsed or refractory Hodgkin lymphoma.
This cohort study assesses the prognostic value of body surface area and National Institutes of Health Skin Score on survival outcomes stratified by erythema and sclerosis subtypes of chronic graft-vs-host disease.
In this observational study, targeted deep DNA sequencing was performed to test the hypothesis that detection of specific residual AML-associated variants in the blood of patients in first remission prior to allogeneic hematopoietic cell transplant would be associated with higher rates of relapse and mortality after transplant
A 72-year-old man presented with right eye conjunctival injection, chemosis, eyelid edema, and pain with eye movements. Examination of the right eye was notable for visual acuity of 20/50, reduced ocular motility in all gazes, proptosis, and chemosis. Treatment with vancomycin and ceftriaxone and ampicillin-sulbactam was followed by a worsening in symptoms. What would you do next?
This Viewpoint examines the equity of US Food and Drug Administration approval and the clinical distribution of chimeric antigen receptor T-cell therapy for patients with multiple myeloma.
A man in his 50s with a history of mycosis fungoides presents with bleeding wounds and nodules on the bilateral hips and forearms. What is your diagnosis?
This cohort study investigates demographic, clinical, and therapeutic factors associated with the risk of malignant neoplasms of the gastrointestinal tract after blood or marrow transplant.
A woman in her 80s initially presented with numerous, primarily photodistributed, crusted, and ulcerated plaques of the trunk and extremities and a medical history of essential thrombocytosis treated with hydroxyurea for 14 years. What is your diagnosis?
This cohort study used national registry data for all children born in Denmark between 1978 to 2015 to examine the association of maternal infection during pregnancy with childhood leukemia among offspring.
This randomized clinical trial of adults with intermediate-risk acute myeloid leukemia explores the optimal therapy for these patients after complete remission.
This case-control study compares the long-term incidence of congestive heart failure in patients treated for breast cancer or lymphoma with anthracycline therapy compared with healthy controls from the same community.
This nested case-control study of 5-year Hodgkin lymphoma survivors explores dose-response associations of radiation therapy and procarbazine with colorectal cancer.
This cross-sectional study of deliveries in US hospitals examines pregnancy outcomes for people with sickle cell disease (SCD) and compares adverse outcomes with Black and Non-Black populations without SCD.
This cross-sectional study compares rates and odds of severe maternal morbidity and other adverse pregnancy outcomes among Black pregnant individuals with sickle cell disease vs anemia.
This cohort study assesses the association of clonal hematopoiesis with progression-free and overall survival among patients with metastatic colorectal and esophagogastric cancers who were undergoing treatment with first-line chemotherapy or immunotherapy.
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