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    Inflammatory Bowel Disease

    Explore the latest in inflammatory bowel disease, including advances in the diagnosis and management of Crohn disease and ulcerative colitis.

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    • Physical Fitness and Inflammatory Bowel Disease Risk Among Children and Adolescents in Taiwan
      JAMA Pediatrics
      Research
      June 1, 2023

      This cohort study examines the association between physical fitness and subsequent risk for inflammatory bowel disease among children and adolescents in Taiwan.

      Gastroenterology Gastroenterology and Hepatology Physical Activity Lifestyle Behaviors Adolescent Medicine
      Full Text | pdf link PDF
    • Paradoxical Psoriasiform Eruptions in Children Receiving Tumor Necrosis Factor α Inhibitors
      JAMA Dermatology
      Research
      April 12, 2023

      This case series characterizes the clinical features and the clinical time course of TNF inhibitor–induced psoriasiform eruptions in children.

      Dermatology Cutaneous Drug Reactions Pediatrics Gastroenterology and Hepatology Gastroenterology
      Full Text | pdf link PDF
    • Patients With Normal Gut Biopsy Still at Increased Risk of IBD
      JAMA
      News
      March 21, 2023
      Gastroenterology Gastroenterology and Hepatology Pathology and Laboratory Medicine
      Full Text | pdf link PDF
    • Effect of Induction Therapy With Olamkicept vs Placebo on Clinical Response in Patients With Active Ulcerative Colitis: A Randomized Clinical Trial
      JAMA
      Research
      March 7, 2023

      This randomized clinical trial compares clinical response at 12 weeks with olamkicept vs placebo in treating adult patients with active ulcerative colitis.

      Gastroenterology Gastroenterology and Hepatology
      Full Text | pdf link PDF
    • Association of All-Cause and Cause-Specific Mortality Risks With Pyoderma Gangrenosum
      JAMA Dermatology
      Research
      February 1, 2023

      This cohort study examines all-cause and cause-specific mortality in patients with pyoderma gangrenosum.

      Dermatology Skin Infections
      Full Text | pdf link PDF
    • Cutaneous Intestinal Metaplasia With Adenocarcinoma Treated With Intralesional Fluorouracil
      JAMA Dermatology
      Case Report
      January 1, 2023

      This case report describes a patient with cutaneous intestinal metaplasia with invasive adenocarcinoma treated successfully with intralesional fluorouracil.

      Dermatology Gastroenterology Gastrointestinal Surgery Surgery Gastroenterology and Hepatology
      Full Text | pdf link PDF
    • Association Between Inflammatory Bowel Disease and Both Psoriasis and Psoriatic Arthritis: A Bidirectional 2-Sample Mendelian Randomization Study
      JAMA Dermatology
      Research
      November 1, 2022

      This mendelian randomization study investigates the associations between inflammatory bowel disease, particularly Crohn disease and ulcerative colitis, and psoriasis and psoriatic arthritis.

      Dermatology Gastroenterology Psoriasis Gastroenterology and Hepatology Rheumatology
      Full Text | pdf link PDF
    • Comparative Outcomes and Safety of Vedolizumab vs Tumor Necrosis Factor Antagonists for Older Adults With Inflammatory Bowel Diseases
      JAMA Network Open
      Research
      September 30, 2022

      This comparative effectiveness study, conducted among a Danish nationwide cohort, compares the effectiveness and safety of vedolizumab vs tumor necrosis factor for older patients with inflammatory bowel disease (IBD).

      Gastroenterology and Hepatology Gastroenterology Geriatrics
      Full Text | pdf link PDF open access
    • Absolute and Relative Risk of New-Onset Psoriasis Associated With Tumor Necrosis Factor-α Inhibitor Treatment in Patients With Immune-Mediated Inflammatory Diseases: A Danish Nationwide Cohort Study
      JAMA Dermatology
      Research
      September 1, 2022

      This cohort study investigates the associated risk between new-onset psoriasis and tumor necrosis factor-α inhibitor treatment compared with nonbiologic conventional treatment.

      Dermatology Psoriasis Pharmacoepidemiology Gastroenterology and Hepatology Gastroenterology
      Full Text | pdf link PDF free
    • Orbital Inflammation in an Adult With Crohn Disease
      JAMA Ophthalmology
      Case Report
      April 1, 2022

      A man aged 57 years with a history of Crohn disease presents to the emergency department after 3 weeks of bilateral periorbital pain and swelling. Computed tomography of the orbits reveals moderate bilateral lateral rectus muscle enlargement and mild enlargement of the left medial rectus muscle. What would you do next?

      Clinical Pharmacy and Pharmacology Gastroenterology Adverse Drug Events Gastroenterology and Hepatology Clinical Challenge
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Development of Cancer Among Patients With Pediatric-Onset Inflammatory Bowel Disease: A Meta-analysis of Population-Based Studies
      JAMA Network Open
      Research
      March 1, 2022

      This meta-analysis evaluates the relative rate of cancer among patients with pediatric-onset inflammatory bowel disease (IBD).

      Gastroenterology and Hepatology Oncology Pediatric Cancer Gastroenterology Pediatrics
      Full Text | pdf link PDF open access
    • Pyoderma Gangrenosum
      JAMA Dermatology
      Case Report
      February 1, 2022

      This case report describes ulcerative plaques with ill-defined, violaceous, and undermined borders with cribriform scarring.

      Dermatology Gastroenterology Hematology Oncology Rheumatology
      Full Text | pdf link PDF
    • Therapeutic Drug Monitoring for Immune-Mediated Inflammatory Diseases
      JAMA
      Opinion
      December 21, 2021
      Clinical Pharmacy and Pharmacology Rheumatoid Arthritis Rheumatology
      Full Text | pdf link PDF
    • Effect of Therapeutic Drug Monitoring vs Standard Therapy During Maintenance Infliximab Therapy on Disease Control in Patients With Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial
      JAMA
      Research
      December 21, 2021

      This randomized clinical trial assesses the effect of therapeutic drug monitoring vs standard therapy on sustained disease control without disease worsening among patients with immune-mediated inflammatory diseases (rheumatoid arthritis, spondyloarthritis, psoriatic arthritis, ulcerative colitis, Crohn disease, or psoriasis) undergoing maintenance therapy with infliximab.

      Clinical Pharmacy and Pharmacology Rheumatoid Arthritis Rheumatology Gastroenterology and Hepatology Dermatology
      Full Text | pdf link PDF | CME & MOC free is active quiz
    • Filgotinib Induces and Maintains Ulcerative Colitis Remission
      JAMA
      News
      July 27, 2021
      Gastroenterology Gastroenterology and Hepatology
      Full Text | pdf link PDF
    • Treatment Strategies for Patients With Immune-Mediated Inflammatory Diseases
      JAMA
      Opinion
      May 4, 2021
      Clinical Pharmacy and Pharmacology Rheumatology Adverse Drug Events Gastroenterology and Hepatology Dermatology
      Full Text | pdf link PDF
    • Effect of Therapeutic Drug Monitoring vs Standard Therapy During Infliximab Induction on Disease Remission in Patients With Chronic Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial
      JAMA
      Research
      May 4, 2021

      This randomized trial assesses the effect of therapeutic drug monitoring vs standard therapy on clinical remission at 30 weeks among patients with immune-mediated inflammatory diseases (rheumatoid arthritis, spondyloarthritis, psoriatic arthritis, ulcerative colitis, Crohn disease, or psoriasis) initiating infliximab therapy.

      Rheumatoid Arthritis Rheumatology Gastroenterology and Hepatology Dermatology Gastroenterology
      Full Text | pdf link PDF | CME & MOC free is active quiz
    • Association of Anti–Tumor Necrosis Factor Therapy With Mortality Among Veterans With Inflammatory Bowel Disease
      JAMA Network Open
      Research
      March 1, 2021

      This cohort study examines the association between use of anti–tumor necrosis factor (TNF) therapy or corticosteroids and all-cause mortality in a national cohort of veterans with inflammatory bowel disease (IBD).

      Gastroenterology and Hepatology Pharmacy and Clinical Pharmacology Allergy and Clinical Immunology Gastroenterology Clinical Pharmacy and Pharmacology
      Full Text | pdf link PDF open access
    • Diagnosis and Treatment of Anal Fissures in 2021
      JAMA
      Review
      February 16, 2021

      This JAMA Insights Clinical Update reviews the diagnosis and management of anal fissures, including use of supportive, topical, injection, and surgical treatment options.

      Dermatology Oncology Surgery Surgical Oncology Anesthesiology
      Full Text | pdf link PDF
    • Management of Crohn Disease: A Review
      JAMA
      Review
      January 5, 2021

      This review discusses the diagnosis and management of Crohn disease, including the importance of disease severity and risk stratification when determining a treatment strategy, the importance of maintenance therapy, and the adverse effects of treatment options.

      Gastrointestinal Surgery Gastroenterology and Hepatology Gastroenterology Surgery
      Full Text | pdf link PDF | CME & MOC is active quiz has multimedia
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