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    Dyslipidemia

    Explore the latest in dyslipidemia, including recent guidelines for screening and use of statins, PCSK9 inhibitors, and other treatments.

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    • Muvalaplin, an Oral Small Molecule Inhibitor of Lipoprotein(a) Formation: A Randomized Clinical Trial
      JAMA
      Research
      September 19, 2023

      This phase 1 randomized clinical trial evaluates the safety, tolerability, pharmacokinetics, and exploratory pharmacodynamic biomarker effects of muvalaplin in humans.

      Cardiology Cardiovascular Risk Factors
      Full Text | pdf link PDF
    • Most Fish Oil Supplements Make Unsupported Claims
      JAMA
      News
      September 19, 2023
      Complementary and Alternative Medicine Cardiovascular Risk Factors Cardiology
      Full Text | pdf link PDF free
    • Longer-Term Efficacy and Safety of Evinacumab in Patients With Refractory Hypercholesterolemia
      JAMA Cardiology
      Research
      September 13, 2023

      This randomized clinical trial investigates if evinacumab provides a sustained reduction in low-density lipoprotein cholesterol level in patients with hypercholesterolemia refractory to maximum-tolerated combinations of currently available lipid-lowering therapies.

      Cardiology Cardiovascular Risk Factors
      Full Text | pdf link PDF open access
    • Use of Tenofovir Alafenamide Fumarate for HIV Pre-Exposure Prophylaxis and Incidence of Hypertension and Initiation of Statins
      JAMA Network Open
      Research
      September 11, 2023

      This cohort study examines the risk of incident hypertension and statin initiation among adults starting pre-exposure prophylaxis with tenofovir alafenamide fumarate compared with propensity score–matched adults taking tenofovir disoproxil fumarate.

      Cardiology HIV Infectious Diseases Cardiovascular Risk Factors Pharmacy and Clinical Pharmacology
      Full Text | pdf link PDF open access
    • Change to Mixed-Lipid Emulsion From Soybean Oil–Based Lipid Emulsion in Pediatric Patients
      JAMA Network Open
      Research
      September 5, 2023

      This cohort study evaluates outcomes of switching from soybean oil–based lipid emulsion to mixed-lipid emulsion parenteral nutrition in pediatric patients.

      Pediatrics Cardiovascular Risk Factors Nutrition, Obesity, Exercise Cardiology Nutrition
      Full Text | pdf link PDF open access
    • Moderate-Intensity Statin With Ezetimibe Combination Therapy vs High-Intensity Statin Monotherapy in Patients at Very High Risk of Atherosclerotic Cardiovascular Disease: A Post Hoc Analysis From the RACING Randomized Clinical Trial
      JAMA Cardiology
      Research
      September 1, 2023

      This post hoc analysis of the Randomized Comparison of Efficacy and Safety of Lipid Lowering With Statin Monotherapy vs Statin/Ezetimibe Combination for High-Risk Cardiovascular Disease (RACING) randomized clinical trial investigates if a moderate-intensity statin plus ezetimibe combination therapy is a feasible therapeutic option for patients with very high-risk atherosclerotic cardiovascular disease.

      Cardiology Clinical Pharmacy and Pharmacology Cardiovascular Risk Factors
      Full Text | pdf link PDF
    • Adenosine Triphosphate Citrate Lyase and Fatty Acid Synthesis Inhibition: A Narrative Review
      JAMA Cardiology
      Review
      September 1, 2023

      This Narrative Review assesses adenosine triphosphate citrate lyase inhibition with bempedoic acid as therapy in high-risk patients who require further low-density lipoprotein cholesterol lowering.

      Cardiology Cardiovascular Risk Factors
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Atherosclerotic Coronary Plaque Regression and Risk of Adverse Cardiovascular Events: A Systematic Review and Updated Meta-Regression Analysis
      JAMA Cardiology
      Research
      August 30, 2023

      This systematic review and meta-regression evaluates the association between coronary plaque regression induced by lipid-lowering therapies and major adverse cardiovascular events.

      Cardiovascular Risk Factors Cardiology Ischemic Heart Disease
      Full Text | pdf link PDF
    • Childhood Parental Incarceration and Adult-Onset Hypertension and Cardiovascular Risk
      JAMA Cardiology
      Research
      August 30, 2023

      This cohort study examines the association of childhood exposure to parental incarceration with cardiovascular risk among a nationally representative sample of US adults.

      Health Disparities Equity, Diversity, and Inclusion Pediatrics Cardiovascular Risk Factors Hypertension
      Full Text | pdf link PDF
    • Projected Outcomes of Optimized Statin and Ezetimibe Therapy in US Military Veterans with Coronary Artery Disease
      JAMA Network Open
      Research
      August 28, 2023

      This cohort study estimates the projected reductions in rates of adverse events associated with coronary artery disease in a large US military veteran population when clinicians optimize oral lipid-lowering therapy as clinically appropriate.

      Cardiology Cardiovascular Risk Factors Veterans Health Ischemic Heart Disease
      Full Text | pdf link PDF open access
    • Community Social Capital and Population Health Outcomes
      JAMA Network Open
      Research
      August 25, 2023

      This cross-sectional study examines the association of economic connectedness, social cohesion, and civic engagement with population health outcomes in all 50 US states.

      Public Health Health Disparities Obesity Health Policy Population Health
      Full Text | pdf link PDF open access
    • Health Claims and Doses of Fish Oil Supplements in the US
      JAMA Cardiology
      Research
      August 23, 2023

      This cross-sectional study investigates the health claims made on the labels of fish oil supplements and the total daily dose of eicosapentaenoic acid and docosahexaenoic acid in commonly available fish oil supplements.

      Complementary and Alternative Medicine Lifestyle Behaviors Nutrition Diet Cardiovascular Risk Factors
      Full Text | pdf link PDF
    • Evaluation of Large-Scale Proteomics for Prediction of Cardiovascular Events
      JAMA
      Research
      August 22, 2023

      This study of 13 540 individuals in Iceland (aged 40-75 years) evaluated the utility of protein risk scores for prediction of atherosclerotic cardiovascular disease events compared to risk prediction using polygenic risk scores in addition to risk scores based on clinical risk factors

      Cardiology Neurology Genetics and Genomics Cardiovascular Risk Factors Ischemic Heart Disease
      Full Text | pdf link PDF
    • Differences in Use of Clinical Decision Support Tools and Implementation of Aspirin, Blood Pressure Control, Cholesterol Management, and Smoking Cessation Quality Metrics in Small Practices by Race and Sex
      JAMA Network Open
      Research
      August 2, 2023

      This cross-sectional study evaluated the association between primary care practice use of electronic health record prompts, standing orders, and clinical registries and disparities by race and sex in practice-level care quality metrics consisting of aspirin use, blood pressure control, cholesterol management, and smoking cessation.

      Equity, Diversity, and Inclusion Health Policy Health Informatics Health Inequities Cardiovascular Risk Factors
      Full Text | pdf link PDF open access
    • Temporal Changes in Obesity-Related Medication After Bariatric Surgery vs No Surgery for Obesity
      JAMA Surgery
      Research
      August 1, 2023

      This cohort study aims to clarify the long-term trajectories of lipid-lowering, cardiovascular, and antidiabetic medication in patients who have undergone bariatric surgery compared with matched patients who received no surgery for morbid obesity.

      Cardiology Cardiovascular Risk Factors Pharmacoepidemiology Clinical Pharmacy and Pharmacology Bariatric Surgery
      Full Text | pdf link PDF open access
    • Benefits of Mandated Registries for Generating Real-World Outcome Data
      JAMA Surgery
      Opinion
      August 1, 2023
      Cardiology Cardiovascular Risk Factors Pharmacoepidemiology Obesity Surgery
      Full Text | pdf link PDF
    • Risk of Cardiovascular Events Among Patients With Head and Neck Cancer
      JAMA Otolaryngology–Head & Neck Surgery
      Research
      August 1, 2023

      This cohort study examines cardiovascular risk profiles, incident stroke, myocardial infarction, and mortality in US veterans with head and neck squamous cell carcinoma.

      Oncology Research, Methods, Statistics Cardiology Cardiovascular Risk Factors Neurology
      Full Text | pdf link PDF
    • Vegetarian Dietary Patterns and Cardiometabolic Risk in People With or at High Risk of Cardiovascular Disease: A Systematic Review and Meta-analysis
      JAMA Network Open
      Research
      July 25, 2023

      This systematic review and meta-analysis examines 20 clinical trials of various vegetarian diets for improved outcomes for patients with major cardiometabolic risk factors.

      Cardiology Lifestyle Behaviors Diet Nutrition, Obesity, Exercise Cardiovascular Risk Factors
      Full Text | pdf link PDF open access
    • Still “on the Fence” About Universal Childhood Lipid Screening: The USPSTF Reaffirms an I Statement
      JAMA
      Opinion
      July 18, 2023
      Adolescent Medicine Cardiology Cardiovascular Risk Factors Pediatrics United States Preventive Services Task Force
      Full Text | pdf link PDF has multimedia
    • Screening for Lipid Disorders in Children and Adolescents
      JAMA
      Patient Information
      July 18, 2023

      This JAMA Patient Page describes lipid disorders, and the pros and cons of screening for them in children and adolescents.

      Patient Information Cardiovascular Risk Factors JAMA Patient Information United States Preventive Services Task Force Cardiology
      Full Text | pdf link PDF free has multimedia
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