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    Lung Cancer

    Explore the latest in lung cancer, including advances in understanding epidemiology, risk factors, treatment biomarkers, and management.

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    • Changes to Primary End Points in Randomized Clinical Trials on Immune Checkpoint Inhibitors in Urothelial, Renal Cell, and Lung Cancers: A Systematic Review
      JAMA Oncology
      Research
      June 8, 2023

      This systematic review investigates how often and to what extent primary end points are changed and reported in immune checkpoint inhibitor clinical trials.

      Targeted and Immune Cancer Therapy Oncology Research, Methods, Statistics Urology Urologic Cancer
      Full Text | pdf link PDF
    • Association Between Duration of Immunotherapy and Overall Survival in Advanced Non–Small Cell Lung Cancer
      JAMA Oncology
      Research
      June 4, 2023

      This cohort study of advanced non–small cell lung cancer patients assesses practice patterns surrounding immunotherapy discontinuation at 2 years and evaluates the association of duration of therapy with overall survival.

      Targeted and Immune Cancer Therapy Oncology
      Full Text | pdf link PDF free
    • Clinical Decision Making in the Real World—The Perfect as the Enemy of the Good
      JAMA Oncology
      Opinion
      June 4, 2023
      Targeted and Immune Cancer Therapy Oncology
      Full Text | pdf link PDF free
    • Tepotinib Treatment in Patients With MET Exon 14–Skipping Non–Small Cell Lung Cancer: Long-term Follow-up of the VISION Phase 2 Nonrandomized Clinical Trial
      JAMA Oncology
      Research
      June 4, 2023

      This cohort study examines the long-term efficacy and safety of tepotinib in patients with MET exon 14–skipping non–small cell lung cancer as a secndary analysis of patients in the VISION nonrandomized clinical trial.

      Targeted and Immune Cancer Therapy Oncology Cancer Genetics
      Full Text | pdf link PDF open access
    • Factors Associated With Nonadherence to Lung Cancer Screening Across Multiple Screening Time Points
      JAMA Network Open
      Research
      May 25, 2023

      This cohort study investigates factors associated with patient nonadherence to lung cancer screening recommendations across multiple time points.

      Oncology Treatment Adherence Radiology Cancer Screening, Prevention, Control
      Full Text | pdf link PDF open access
    • Assessment of Tyrosine Kinase Inhibitors and Survival and Cardiovascular Outcomes of Patients With Non–Small Cell Lung Cancer in Taiwan
      JAMA Network Open
      Research
      May 17, 2023

      This cohort study compares risk of death and major adverse cardiac and cerebrovascular events among patients with non–small cell lung cancer (NSCLC) receiving tyrosine kinase inhibitors (TKIs) vs those not receiving TKIs in a nationwide cohort in Taiwan.

      Oncology Adverse Drug Events Cardiovascular Risk Factors Cardiology Clinical Pharmacy and Pharmacology
      Full Text | pdf link PDF open access
    • Association of Weight Loss in Ambulatory Care Settings With First Diagnosis of Lung Cancer in the US
      JAMA Network Open
      Research
      May 11, 2023

      This case-control study of US adults examines the association of weight loss with future lung cancer diagnosis.

      Oncology Nutrition, Obesity, Exercise
      Full Text | pdf link PDF open access
    • Adjuvant Treatments for Surgically Resected Non–Small Cell Lung Cancer Harboring EGFR Mutations: A Review
      JAMA Oncology
      Review
      May 11, 2023

      This review reports current evidence on outcomes of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor treatment in patients with resectable EGFR mutation–positive non–small cell lung cancer.

      Cardiothoracic Surgery Oncology Cancer Genetics Surgery Surgical Oncology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Research Shows Air Pollution Promotes Lung Cancer
      JAMA
      News
      May 9, 2023
      Oncology Environmental Health Pulmonary Medicine
      Full Text | pdf link PDF
    • Significant Incidental Findings in the National Lung Screening Trial
      JAMA Internal Medicine
      Research
      May 8, 2023

      This case series study examines significant incidental findings reported in the low-dose computed tomography arm of the National Lung Screening Trial.

      Radiology Cancer Screening, Prevention, Control Oncology Pulmonary Medicine Chronic Obstructive Pulmonary Disease
      Full Text | pdf link PDF
    • Red Flag on Electrocardiogram Findings in a Patient With Lung Cancer
      JAMA Internal Medicine
      Case Report
      May 8, 2023

      This case report describes a patient in their early 70s with sudden onset squeezing precordial chest pain, back pain, and nausea, and a history of long-term lung cancer treatment.

      Clinical Pharmacy and Pharmacology Emergency Medicine Targeted and Immune Cancer Therapy Oncology Challenges in Clinical Electrocardiography
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Prediagnosis Smoking Cessation and Overall Survival Among Patients With Non–Small Cell Lung Cancer
      JAMA Network Open
      Research
      May 5, 2023

      This cohort study examines the association of years since smoking cessation before diagnosis and cumulative smoking pack-years with overall survival in patients with non–small cell lung cancer.

      Oncology Tobacco and e-Cigarettes Lifestyle Behaviors
      Full Text | pdf link PDF open access
    • Practice-Level Variation in Molecular Testing and Use of Targeted Therapy for Patients With Non–Small Cell Lung Cancer and Colorectal Cancer
      JAMA Network Open
      Research
      April 28, 2023

      This cross-sectional study compares rates of molecular testing and targeted therapy among patients with non–small cell lung cancer (NSCLC) and colorectal cancer (CRC) use by practice type and across practices.

      Health Policy Pharmacy and Clinical Pharmacology Genetics and Genomics Oncology Cancer Genetics
      Full Text | pdf link PDF open access
    • Assessment of Gender-Specific COVID-19 Case Fatality Risk per Malignant Neoplasm Type
      JAMA Oncology
      Research
      April 27, 2023

      This cohort study examines the gender-specific COVID-19 case fatality risks among patients with a malignant neoplasm

      Cancer Epidemiology Coronavirus (COVID-19) Oncology Hematology Ovarian Cancer
      Full Text | pdf link PDF free
    • Anti-EGFR Therapy for Left-Sided RAS Wild-type Colorectal Cancer—PARADIGM Shift
      JAMA Oncology
      Opinion
      April 18, 2023
      Colorectal Cancer Gastroenterology Gastrointestinal Cancer Targeted and Immune Cancer Therapy Oncology
      Full Text | pdf link PDF
    • Molecular Marker Testing in Curable Non–Small Cell Lung Cancer—Practice Necessarily Precedes Data
      JAMA Oncology
      Opinion
      April 13, 2023

      This Viewpoint describes the use of broad molecular marker testing in patients with early-stage non–small cell lung cancer

      Cancer Biomarkers Oncology
      Full Text | pdf link PDF
    • Assessment of Phase 3 Randomized Clinical Trials Including Patients With Leptomeningeal Disease: A Systematic Review
      JAMA Oncology
      Research
      April 1, 2023

      This systematic review examines the proportion of patients with leptomeningeal disease included in phase 3 randomized clinical trials for patients with metastatic breast cancer, lung cancer, and melanoma.

      Breast Cancer Neuro-oncology Neurology Oncology Women's Health
      Full Text | pdf link PDF
    • Association of Immune-Related Adverse Events With Efficacy of Atezolizumab in Patients With Non–Small Cell Lung Cancer: Pooled Analyses of the Phase 3 IMpower130, IMpower132, and IMpower150 Randomized Clinical Trials
      JAMA Oncology
      Research
      April 1, 2023

      This analysis of pooled data from 3 randomized clinical trials evaluates the association between immune-related adverse events and atezolizumab efficacy in patients with advanced non–small cell lung cancer.

      Dermatology Cutaneous Drug Reactions Targeted and Immune Cancer Therapy Oncology
      Full Text | pdf link PDF open access
    • Recalibration of a Deep Learning Model for Low-Dose Computed Tomographic Images to Inform Lung Cancer Screening Intervals
      JAMA Network Open
      Research
      March 16, 2023

      This diagnostic study uses deep learning algorithms to evaluate 4 models that use computed tomographic imaging features of a presumed nonmalignant lung nodule to predict lung cancer detection at 1 year among patients in the National Lung Screening Trial.

      Oncology Health Informatics Cancer Screening, Prevention, Control Pulmonary Medicine
      Full Text | pdf link PDF open access
    • Trends in Survival Rates of Non–Small Cell Lung Cancer With Use of Molecular Testing and Targeted Therapy in Korea, 2010-2020
      JAMA Network Open
      Research
      March 16, 2023

      This cohort study investigates survival rates for non–small cell lung cancer in Korea from 2010 to 2020 with use of molecular testing and targeted therapy.

      Oncology Cancer Genetics Cancer Epidemiology Genetics and Genomics Targeted and Immune Cancer Therapy
      Full Text | pdf link PDF open access
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