Explore the latest in movement disorders, including Parkinson and Huntington disease, progressive supranuclear palsy, and essential tremor.
This case-control study investigates cerebrospinal fluid levels of neurofilament light protein in participants with various forms of dementia, motor neuron disease, and movement disorders and controls, as determined by clinical and autopsy-definite criteria.
This cohort study describes the efficacy and safety of internal globus pallidus deep brain stimulation in Filipino patients with severe X-linked dystonia parkinsonism and predominant dystonia.
A 16-year-old girl presents with unsteadiness of gait, frequent falls, and unusual fundoscopy results. What is your diagnosis?
This case report describes a rare neurodegenerative cause of an encephalopathic episode in a young man with cerebral atrophy and leukencephalopathy that initially appeared similar to meningitis.
This review discusses the clinical manifestations and molecular basis of McLeod syndrome in comparison with other neuroacanthoscytosis syndromes, provides a comprehensive listing of alleles with involvement in McLeod syndrome, and discusses molecular tools to elucidate the genetic cause of the syndrome.
This case-control cohort study used next-generation sequencing data to determine whether for loss of function variants in LRRK1 and LRRK2 are associated with the etiology of Parkinson disease.
This Viewpoint presents temporal interference stimulation, an optimized alternative to deep brain stimulation, transcranial magnetic stimulation, and transcranial electrical stimulation.
This cross-sectional observational study characterizes the normative voice tremor frequency in patients with essential vocal tremor.
This personal narrative shares insights gleaned after the author’s father, a patient with Parkinson disease, experiences a cervical spine fracture that mandates a complicated hospitalization.
This randomized clinical trial evaluates the safety and tolerability of multiple intravenous infusions of PRX002/RG7935 (anti–α-synuclein monoclonal) vs placebo in patients with idiopathic Parkinson disease.
This cross-sectional study analyzes data from the Centers for Medicare & Medicaid Services to identify both effective and ineffective dementia medication prescribing patterns as well as patient characteristics and comorbid conditions associated with dementia treatment among older Medicare beneficiaries with Parkinson disease.
This study aims to develop and evaluate a targeted sequencing approach using a customized panel of genes associated with movement disorders.
This systematic review and meta-analysis investigates the dose-response association between levels of physical activity and the risk of Parkinson disease by examining data from 8 studies including more than half a million participants.
This narrative review describes the evidence for propagation of distinct tau strains in Alzheimer disease and mechanistic insights into cell-to-cell transmission of pathological tau in multiple neurodegenerative diseases, including Alzheimer disease, progressive supranuclear palsy, corticobasal degeneration, and Pick disease.
This Swedish national register-based study investigates the association of Tourette syndrome and chronic tic disorders with objectively measured educational outcomes, adjusting for psychiatric comorbidities and factors shared between siblings.
This cohort study uses 2 large administrative claims databases to examine the incidence of Parkinson disease among patients with inflammatory bowel disease and to assess whether exposure to antitumor necrosis factor therapy among these patients mitigates Parkinson disease risk.
This brain bank case-control study analyzes disease-specific inclusions in the key structures of the circadian system in patients with Parkinson disease, multiple system atrophy, and progressive supranuclear palsy.
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