Explore the latest in movement disorders from The JAMA Network, including Parkinson and Huntington disease, progressive supranuclear palsy, and essential tremor.
This population-based study investigates the cumulative association of established genetic risk factors for Parkinson disease with cognitive impairment and reexamines the association of the polygenetic risk score with motor progression and survival among patients with Parkinson disease.
This study uses patients in the International Deep Brain Stimulation Database and Registry to assess the efficacy and safety of deep brain stimulation in a multinational cohort of patients with Tourette syndrome.
This longitudinal study examines whether the course of Parkinson disease in patients with the LRRK2 mutation differs from the course of Parkinson disease in patients without the mutation.
This case reports describes Pisa syndrome in a child with subacute sclerosing panencephalitis.
This randomized clinical trial evaluates the safety and potential symptomatic effects of deep brain stimulation of the nucleus basalis of Meynert in patients with Parkinson disease dementia.
This Arts and Medicine essay explores the relevance of writer and artist William S. Burroughs to clinical medicine, and his importance to the author’s career as a Parkinson disease researcher.
This phase 2 randomized clinical trial examines the feasibility and safety of high-intensity treadmill exercise in patients with de novo Parkinson disease who are not taking medication and whether the effect on the motor system warrants a phase 3 trial.
This review reports the ablative and nonablative applications of transcranial focused ultrasound for neurological conditions.
This case-control study evaluates the associations between β-amyloid, tau pathology, and cognition by comparing cognitively normal and mildly cognitively impaired patients with Parkinson disease with healthy control participants.
This population-based cohort study from the Rotterdam Study evaluates the association between cognitive function and risk of parkinsonism or Parkinson disease in participants who were free of parkinsonism and dementia.
This randomized clinical trial compares focused ultrasound thalamotomy with sham treatment for relieving tremor in patients with medication-refractory, tremor-dominant Parkinson disease.
This study uses data from the Track and COHORT studies to examine an approach to planning prediagnosis clinical trials for Huntington disease.
This cohort study evaluates outcomes for patients treated with botulinum toxin applied to the buccinator muscle in the setting of facial synkinesis.
This Viewpoint discusses the most recent advances in diagnosis of and treatment for Parkinson disease.
This cross-sectional study investigates the association between brain metabolism and motor scores of patients with early Huntington disease.