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    Movement Disorders

    Explore the latest in movement disorders, including Parkinson and Huntington disease, progressive supranuclear palsy, and essential tremor.

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    • Ultrasound Treatment Improved Parkinson Disease Symptoms
      JAMA
      News
      March 28, 2023
      Neurology Parkinson Disease
      Full Text | pdf link PDF free
    • Identifying Replicable Subgroups in Neurodevelopmental Conditions Using Resting-State Functional Magnetic Resonance Imaging Data
      JAMA Network Open
      Research
      March 13, 2023

      This case-control study identifies subgroups of children with and without neurodevelopmental conditions with shared brain characteristics using functional magnetic resonance imaging (fMRI) data from 2 large, independent data sets.

      Child Development Psychiatry and Behavioral Health Child and Adolescent Psychiatry Radiology Neuroimaging
      Full Text | pdf link PDF open access
    • Physical Frailty, Genetic Predisposition, and Incident Parkinson Disease
      JAMA Neurology
      Research
      March 13, 2023

      This cohort study attempts to examine the longitudinal association of frailty phenotype with the development of Parkinson disease and to explore the modification role of genetic risk of Parkinson disease in such association.

      Genetics and Genomics Neurogenetics Geriatrics Neurology Parkinson Disease
      Full Text | pdf link PDF
    • Limb to Cranial Overflow Dystonia in a Patient After Stroke
      JAMA Neurology
      Case Report
      March 6, 2023

      This case report describes noncontiguous overflow dystonia in a patient with diabetes, hypertension, and a history of left putaminal hemorrhage and right hemiparesis.

      Neurology Images in Neurology Stroke Cerebrovascular Disease Cerebrovascular Infarction
      Full Text | pdf link PDF | CME & MOC is active quiz has multimedia
    • Tic Status in Tourette Syndrome Due to Depletion of the Deep Brain Stimulation Battery
      JAMA Neurology
      Case Report
      March 1, 2023

      In this case report, a patient with Tourette syndrome was admitted to the emergency department with nonrhythmic, continuous, generalized hyperkinetic movements associated with muscle contractions in the trunk, neck, and upper and lower limbs caused by depletion of the deep brain stimulation battery.

      Neurology Neurosurgery Psychiatric Surgery and Procedures Images in Neurology
      Full Text | pdf link PDF | CME & MOC is active quiz has multimedia
    • Neurologic Dysfunction Assessment in Parkinson Disease Based on Fundus Photographs Using Deep Learning
      JAMA Ophthalmology
      Research
      March 1, 2023

      This decision analytical model investigates the ability of a deep learning system to assess neurologic dysfunction in Parkinson disease using fundus images.

      Ophthalmic Imaging Ophthalmology Health Informatics Neurology Parkinson Disease
      Full Text | pdf link PDF
    • Deep Learning Using Images of the Retina for Assessment of Severity of Neurological Dysfunction in Parkinson Disease
      JAMA Ophthalmology
      Opinion
      March 1, 2023
      Ophthalmic Imaging Health Informatics Neurology Parkinson Disease Retinal Disorders
      Full Text | pdf link PDF
    • Widening the Spectrum of Risk Factors, Comorbidities, and Prodromal Features of Parkinson Disease
      JAMA Neurology
      Research
      February 1, 2023

      This case-control study investigates the risk factors, comorbidities, and prodromal symptoms associated with a diagnosis of Parkinson disease in a large representative database.

      Neurology Parkinson Disease Sleep Medicine Epilepsy and Seizures Tremor
      Full Text | pdf link PDF open access
    • The Future of Functional Neuroimaging in Parkinsonism: Prove It!
      JAMA Neurology
      Opinion
      February 1, 2023

      This Viewpoint discusses the current lack of evidence of functional neuroimaging affecting patient outcomes in parkinsonian conditions.

      Neurology Radiology Neuroimaging Parkinson Disease
      Full Text | pdf link PDF
    • Abandoning the Proteinopathy Paradigm in Parkinson Disease
      JAMA Neurology
      Opinion
      February 1, 2023

      This Viewpoint makes a case for changing the approach in Parkinson disease research efforts from one of proteinopathy (accrual of amyloids) to proteinopenia (depletion of normal proteins).

      Neurology Parkinson Disease
      Full Text | pdf link PDF
    • Functional Impairment Preceding Parkinson Disease Diagnosis—What’s in a Prodrome?
      JAMA Neurology
      Opinion
      February 1, 2023
      Neurology Parkinson Disease
      Full Text | pdf link PDF
    • Functional Impairment in Individuals With Prodromal or Unrecognized Parkinson Disease
      JAMA Neurology
      Research
      February 1, 2023

      This case-control study uses Medicare-linked data from the National Health and Aging Trends Study to examine whether limitations in daily functioning existed in the 3 years before a diagnosis of Parkinson disease in a sample of Medicare beneficiaries.

      Neurology Parkinson Disease Geriatrics
      Full Text | pdf link PDF
    • Association Between Antiepileptic Drugs and Incident Parkinson Disease
      JAMA Neurology
      Research
      February 1, 2023

      This case-control study investigates the association between antiepileptic drugs and incident Parkinson disease.

      Epilepsy and Seizures Neurology Pharmacoepidemiology Parkinson Disease
      Full Text | pdf link PDF
    • Muhammad Ali and Young-Onset Idiopathic Parkinson Disease—The Missing Evidence
      JAMA Neurology
      Opinion
      January 1, 2023

      This Viewpoint discusses the degree to which Parkinson disease vs repetitive boxing-related head trauma contributed to Muhammad Ali’s progressive motor and cognitive impairments.

      Neurology Parkinson Disease
      Full Text | pdf link PDF
    • Diagnostic Optic Nerve Features in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay
      JAMA Neurology
      Case Report
      January 1, 2023

      This case report describes the optic nerve features of a male patient aged 23 years with a diagnosis of autosomal recessive spastic ataxia of Charlevoix-Saguenay.

      Neurogenetics Neurology Ophthalmic Imaging Spinal Cord Disorders Images in Neurology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Associations of Greenness, Parks, and Blue Space With Neurodegenerative Disease Hospitalizations Among Older US Adults
      JAMA Network Open
      Research
      December 20, 2022

      This cohort study explores the association of natural environments—using measures of greenness, parks, and blue space—with hospitalizations for Alzheimer disease and related dementias and Parkinson disease among older individuals in the US.

      Environmental Health Parkinson Disease Dementia and Cognitive Impairment Neurology Geriatrics
      Full Text | pdf link PDF open access
    • Timing of Physical Therapy Sessions for Individuals With Parkinson Disease May Unlock Benefits
      JAMA Neurology
      Opinion
      December 1, 2022

      This Viewpoint advocates for careful consideration in the timing of physical therapy for individuals with Parkinson disease as a possible avenue toward improved outcomes.

      Neurology Parkinson Disease Physical Therapy
      Full Text | pdf link PDF
    • Evaluation of Simvastatin as a Disease-Modifying Treatment for Patients With Parkinson Disease: A Randomized Clinical Trial
      JAMA Neurology
      Research
      December 1, 2022

      This randomized clinical trial evaluates whether simvastatin has potential as a disease-modifying treatment for patients with moderate Parkinson disease.

      Neurology Parkinson Disease
      Full Text | pdf link PDF open access has multimedia
    • Association of Premenopausal Bilateral Oophorectomy With Parkinsonism and Parkinson Disease
      JAMA Network Open
      Research
      October 26, 2022

      This cohort study uses data from the Mayo Clinic Cohort Study of Oophorectomy and Aging 1 and 2 to assess the association between premenopausal bilateral oophorectomy and the risk of parkinsonism and Parkinson disease in women.

      Obstetrics and Gynecology Gynecology Women's Health Neurology Parkinson Disease
      Full Text | pdf link PDF open access
    • Levodopa Content of Mucuna pruriens Supplements in the NIH Dietary Supplement Label Database
      JAMA Neurology
      Research
      October 1, 2022

      This case series assesses the levels of levodopa in Mucuna pruriens supplements available in the US that are included in the National Institutes of Health Dietary Supplement Label Database.

      Complementary and Alternative Medicine Neurology Parkinson Disease
      Full Text | pdf link PDF
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