Explore the latest in myeloma, including recent advances in diagnosis and management of monoclonal gammopathy and multiple myeloma.
This cohort study investigates the association of prediagnostic serum immune markers with the subsequent diagnosis of stable monoclonal gammopathy of undetermined significance vs progression to multiple myeloma.
A woman in her late 60s presented with progressive, painless blurring of vision in both eyes. She had bilateral, gray-white, irregular, poorly circumscribed, linear and nummular central and peripheral corneal opacities. What would you do next?
This Viewpoint presents 4 arguments against routinely substituting zoledronic acid with denosumab in patients with newly diagnosed multiple myeloma.
This case report describes a 73-year-old man with multiple myeloma who presented with bilateral foggy vision and visual field constrictions while he was taking daratumumab.
This case report describes a patient with systemic amyloidosis.
A 60-year-old man with a history of IgA kappa multiple myeloma was referred for evaluation of an indolent, erythematous papule on his glans penis of 2 weeks’ duration; he denied sexual risk behavior and reported no recent changes in medication. What is your diagnosis?
This case report describes a diagnostically challenging electrocardiography finding after apparent chemotherapy infusion reaction.
This nonrandomized clinical trial examines the safety, tolerability, immunogenicity, and anti–multiple myeloma activity of the PVX-410 multipeptide vaccine with or without lenalidomide.
This 5-year follow-up of a phase 2 clinical trial assesses long-term durability of minimal residual disease–negative remission and time to disease progression among patients with newly diagnosed multiple myeloma who received triplet-based induction therapy with lenalidomide maintenance therapy.
This Clinical Evidence Synopsis summarizes a Cochrane review of randomized trials comparing the effects of bisphosphonate therapy vs placebo or no treatment on mortality, vertebral fractures, nonvertebral fractures, and skeletal-related events among patients with multiple myeloma.
This systematic review and network meta-analysis analyzes and compares different maintenance regimens for treating patients with newly diagnosed multiple myeloma and associated progression-free and overall survival.
This systematic analysis reports incidence, mortality, and disability-adjusted life-year (DALY) estimates from the Global Burden of Disease 2016 study to characterize the burden of multiple myeloma and the availability of effective therapies for 21 world regions and 195 countries and territories from 1990 to 2016.
This case series assesses whether environmental exposures from the World Trade Center disaster site are associated with multiple myeloma and its precursor disease, monoclonal gammopathy of undetermined significance, in New York City firefighters.
This systematic review with meta-analysis examines the rates of cardiovascular adverse events among patients receiving carfilzomib for the treatment of multiple myeloma.
This systematic review and meta-analysis reviews phase 3 randomized clinical trials of high-dose therapy followed by autologous stem cell transplant in patients with multiple myeloma.
This randomized clinical trial compares the effects of hemodialysis using a high-cutoff dialyzer (with very large membrane pores and high permeability to immunoglobulin light chains) vs a conventional high-flux dialyzer (with small pores and lower permeability) on hemodialysis independence among patients with biopsy-proven myeloma cast nephropathy requiring hemodialysis in France.
This Diagnostic Test Interpretation examines serum protein electrophoresis and free light chain assay results in a patient with myeloma.
A woman in her 60s presented with multiple painful cutaneous nodules and a history of IgGκ multiple myeloma. What is your diagnosis?
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