Explore the latest in myeloma, including recent advances in diagnosis and management of monoclonal gammopathy and multiple myeloma.
This nonrandomized clinical trial examines the safety, tolerability, immunogenicity, and anti–multiple myeloma activity of the PVX-410 multipeptide vaccine with or without lenalidomide.
This 5-year follow-up of a phase 2 clinical trial assesses long-term durability of minimal residual disease–negative remission and time to disease progression among patients with newly diagnosed multiple myeloma who received triplet-based induction therapy with lenalidomide maintenance therapy.
A 60-year-old man with a history of IgA kappa multiple myeloma was referred for evaluation of an indolent, erythematous papule on his glans penis of 2 weeks’ duration; he denied sexual risk behavior and reported no recent changes in medication. What is your diagnosis?
This case report describes a diagnostically challenging electrocardiography finding after apparent chemotherapy infusion reaction.
This Clinical Evidence Synopsis summarizes a Cochrane review of randomized trials comparing the effects of bisphosphonate therapy vs placebo or no treatment on mortality, vertebral fractures, nonvertebral fractures, and skeletal-related events among patients with multiple myeloma.
This systematic review and network meta-analysis analyzes and compares different maintenance regimens for treating patients with newly diagnosed multiple myeloma and associated progression-free and overall survival.
This systematic analysis reports incidence, mortality, and disability-adjusted life-year (DALY) estimates from the Global Burden of Disease 2016 study to characterize the burden of multiple myeloma and the availability of effective therapies for 21 world regions and 195 countries and territories from 1990 to 2016.
This case series assesses whether environmental exposures from the World Trade Center disaster site are associated with multiple myeloma and its precursor disease, monoclonal gammopathy of undetermined significance, in New York City firefighters.
This systematic review with meta-analysis examines the rates of cardiovascular adverse events among patients receiving carfilzomib for the treatment of multiple myeloma.
This systematic review and meta-analysis reviews phase 3 randomized clinical trials of high-dose therapy followed by autologous stem cell transplant in patients with multiple myeloma.
This randomized clinical trial compares the effects of hemodialysis using a high-cutoff dialyzer (with very large membrane pores and high permeability to immunoglobulin light chains) vs a conventional high-flux dialyzer (with small pores and lower permeability) on hemodialysis independence among patients with biopsy-proven myeloma cast nephropathy requiring hemodialysis in France.
This Diagnostic Test Interpretation examines serum protein electrophoresis and free light chain assay results in a patient with myeloma.
A woman in her 60s presented with multiple painful cutaneous nodules and a history of IgGκ multiple myeloma. What is your diagnosis?
This review examines the incidence, clinical presentations, and mechanisms of cardiovascular complications in patients with multiple myeloma.
An 80-year-old man with stage 4 chronic kidney disease, 2 days of anuria, and an elevated serum κ to λ free light chain ratio had a bone marrow biopsy that stained positive for the plasma cell marker CD138. What would you do next?
This case report describes a woman in her 40s with a history of plasma cell leukemia who presented with 1 month of intermittent headaches followed by a seizure.
This noninferiority trial compares the effects of zoledronic acid administered every 12 weeks vs every 4 weeks over 2 years on prevention of skeletal events in patients with bone metastases due to breast cancer, prostate cancer, or multiple myeloma.
This meta-analysis examines the prognostic value of minimal residual disease assessment as associated with survival outcomes in patients with newly diagnosed multiple myeloma.
This case report describes resolution of nail changes of systemic amyloidosis after bone-marrow transplantation in a patient with multiple myeloma.
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