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    Demyelinating Disorders

    Explore the latest in demyelinating disorders, including the etiology, diagnosis, and management of multiple sclerosis and neuromyelitis optica.

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    • After a Night of Odd Angles
      JAMA
      Humanities
      March 7, 2023
      Neurology Poetry Poetry and Medicine
      Full Text | pdf link PDF free
    • Efficacy and Safety of Proposed Biosimilar Natalizumab (PB006) in Patients With Relapsing-Remitting Multiple Sclerosis: The Antelope Phase 3 Randomized Clinical Trial
      JAMA Neurology
      Research
      March 1, 2023

      This randomized clinical trial evaluates matching efficacy, safety, and immunogenicity between biosimilar natalizumab and reference natalizumab in patients with relapsing-remitting multiple sclerosis.

      Neurology Multiple Sclerosis
      Full Text | pdf link PDF open access
    • Serum Glial Fibrillary Acidic Protein Compared With Neurofilament Light Chain as a Biomarker for Disease Progression in Multiple Sclerosis
      JAMA Neurology
      Research
      March 1, 2023

      This cohort study investigates if concentrations of serum glial fibrillary acidic protein and neurofilament light chain are associated with and prognostic for disease progression in patients with multiple sclerosis.

      Neurology Multiple Sclerosis
      Full Text | pdf link PDF
    • Association of Serum Neurofilament Light Chain Levels at Disease Onset With Disability Worsening in Patients With a First Demyelinating Multiple Sclerosis Event Not Treated With High-Efficacy Drugs
      JAMA Neurology
      Research
      February 27, 2023

      This cohort study assesses the association between serum neurofilament light chain (sNfL) levels and long-term worsening disability among patients with multiple sclerosis not treated with high-efficacy drugs.

      Neurology Multiple Sclerosis
      Full Text | pdf link PDF
    • What Is Guillain-Barré Syndrome?
      JAMA
      Patient Information
      February 21, 2023

      This JAMA Patient Page describes the autoimmune disease Guillain-Barré syndrome and its risk factors, diagnosis, treatment, and prognosis.

      Neurology Neuropathy Patient Information JAMA Patient Information
      Full Text | pdf link PDF free
    • Targeting B Cells and Microglia in Multiple Sclerosis With Bruton Tyrosine Kinase Inhibitors: A Review
      JAMA Neurology
      Review
      February 13, 2023

      This narrative review discusses the use of BTK inhibitors as disease-modifying therapies for multiple sclerosis, outlining their mechanism of action, development, and clinical use and comparing information from clinical trials.

      Neurology Multiple Sclerosis
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Episodic Facial Paresis—An Isolated Presenting Symptom of Multiple Sclerosis
      JAMA Otolaryngology–Head & Neck Surgery
      Case Report
      February 9, 2023

      This case report describes a case of a man in his 30s who presented with episodic right lower facial paresis for 10 days and was diagnosede with an episodic, transient pattern of unilateral facial palsy associated with relapsing remitting multiple sclerosis.

      Facial Nerve Facial Plastic Surgery Dental Medicine Neurology Multiple Sclerosis
      Full Text | pdf link PDF has multimedia
    • Association of Early Progression Independent of Relapse Activity With Long-term Disability After a First Demyelinating Event in Multiple Sclerosis
      JAMA Neurology
      Research
      February 1, 2023

      This cohort study investigates the long-term outcomes of patients who develop progression independent of relapse activity after a first demyelinating event in multiple sclerosis.

      Neurology Multiple Sclerosis
      Full Text | pdf link PDF open access
    • Time to Change the Current Clinical Classification of Multiple Sclerosis?
      JAMA Neurology
      Opinion
      February 1, 2023
      Neurology Multiple Sclerosis
      Full Text | pdf link PDF
    • Changes in Distribution of Severe Neurologic Involvement in US Pediatric Inpatients With COVID-19 or Multisystem Inflammatory Syndrome in Children in 2021 vs 2020
      JAMA Neurology
      Research
      January 1, 2023

      This case series assesses data from 55 US hospitals about neurologic involvement in children and adolescents with acute COVID-19 or multisystem inflammatory syndrome in children.

      Infectious Diseases Rheumatology CNS Infections Coronavirus (COVID-19) Pediatrics
      Full Text | pdf link PDF | CME & MOC open access is active quiz
    • What Is Multiple Sclerosis?
      JAMA
      Patient Information
      November 22, 2022

      This JAMA Patient Page describes the types of multiple sclerosis and its symptoms, diagnosis, treatment options, and recommended lifestyle modifications.

      Neurology Patient Information Multiple Sclerosis JAMA Patient Information
      Full Text | pdf link PDF free has multimedia
    • Effect of Dimethyl Fumarate vs Interferon β-1a in Patients With Pediatric-Onset Multiple Sclerosis: The CONNECT Randomized Clinical Trial
      JAMA Network Open
      Research
      September 28, 2022

      This randomized clinical trial investigates the efficacy and safety of dimethyl fumarate vs interferon β-1a for treatment of pediatric-onset multiple sclerosis.

      Neurology Multiple Sclerosis Pediatrics
      Full Text | pdf link PDF open access
    • Considering the Future of Pediatric Multiple Sclerosis Trials After the CONNECT Open-Label Randomized Trial
      JAMA Network Open
      Opinion
      September 28, 2022
      Neurology Multiple Sclerosis Pediatrics
      Full Text | pdf link PDF open access
    • Risk of Guillain-Barré Syndrome Among Older Adults Receiving Influenza Vaccine in Taiwan
      JAMA Network Open
      Research
      September 21, 2022

      This cross-sectional study investigates the association between seasonal influenza vaccination and incidence of Guillain-Barré syndrome among adults 65 years or older in Taiwan.

      Public Health Vaccination Infectious Diseases Influenza Neurology
      Full Text | pdf link PDF open access
    • Disease-Modifying Treatments and Time to Loss of Ambulatory Function in Patients With Primary Progressive Multiple Sclerosis
      JAMA Neurology
      Research
      September 1, 2022

      This comparative effectiveness research study investigates the effectiveness of disease-modifying treatments in patients with primary progressive multiple sclerosis with or without active disease.

      Neurology Multiple Sclerosis
      Full Text | pdf link PDF
    • Analysis of Pregnancy-Related Attacks in Neuromyelitis Optica Spectrum Disorder: A Systematic Review and Meta-Analysis
      JAMA Network Open
      Research
      August 4, 2022

      This systematic review and meta-analysis assesses factors associated with pregnancy-related be increased in the postpartum period of neuromyelitis attacks, annualized relapse rate, and Expanded Disability Status Scale score in each phase of pregnancy among patients with NMOSD.

      Neurology Pregnancy Obstetrics Obstetrics and Gynecology Neuromyelitis Optica
      Full Text | pdf link PDF open access
    • Livedo Reticularis—A Presenting Sign of Neuromyelitis Optica Spectrum Disorder
      JAMA Neurology
      Case Report
      August 1, 2022

      This case report describes a man aged 58 years who presented with intermittent chest pain, numbness and tingling of the upper extremities, and a violaceous, reticular rash on his lower extremities, abdomen, and flank.

      Dermatology Images in Neurology Neuro-ophthalmology Neurology Ophthalmology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Reinterpreting Clinical Trials in Children With Multiple Sclerosis Using a Bayesian Approach
      JAMA Neurology
      Research
      August 1, 2022

      This systematic review and meta-analysis investigates the use of the bayesian approach to estimate the plausible effect of teriflunomide in children with multiple sclerosis.

      Neurology Research, Methods, Statistics Multiple Sclerosis Pediatrics
      Full Text | pdf link PDF
    • Association of Brain Atrophy With Disease Progression Independent of Relapse Activity in Patients With Relapsing Multiple Sclerosis
      JAMA Neurology
      Research
      July 1, 2022

      This cohort study examines magnetic resonance imaging scans to determine changes in regional and total brain volume among patients with relapsing multiple sclerosis who have disease progression without relapse activity.

      Neurology Multiple Sclerosis Neuroimaging Radiology
      Full Text | pdf link PDF open access
    • Factors Associated With Serological Response to SARS-CoV-2 Vaccination in Patients With Multiple Sclerosis Treated With Rituximab
      JAMA Network Open
      Research
      May 11, 2022

      This cohort study conducted at a specialized multiple sclerosis (MS) clinic investigates factors associated with serological response to tozinameran in patients with MS receiving rituximab.

      Neurology Vaccination Allergy and Clinical Immunology Coronavirus (COVID-19) Multiple Sclerosis
      Full Text | pdf link PDF open access
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