Myasthenia Gravis

This randomized clinical trial investigates the efficacy and safety of rituximab compared vs placebo as an add-on with standard of care for myasthenia gravis.

This parallel-group, randomized, single-blind clinical trial compares rapid- with slow-tapering dosing regimens of prednisone in patients with generalized myasthenia gravis who have achieved minimal manifestation status.

This cohort study compares the use of rituximab in patients with refractory and new-onset generalized myasthenia gravis as well as in patients receiving conventional immunotherapy.

This randomized clinical trial evaluates the clinical effects of zilucoplan, a subcutaneously self-administered macrocyclic peptide inhibitor of complement component 5, in a broad population of patients with moderate to severe generalized myasthenia gravis.

This study assesses the response to rituximab in the treatment of patients with refractory acetylcholine receptor autoantibody–positive generalized myasthenia gravis.

This cross-sectional study examines the clinical features of patients with double-seronegative myasthenia gravis who have cortactin antibodies.

This study reports 7 cases of severe myasthenia gravis treated with autologous hematopoietic stem cell transplant in which consistent, durable, symptom-free, and treatment-free remission was achieved.

This cohort study reports a significant association between older age, male sex, and progression to generalized myasthenia gravis and positive acetylcholine receptor antibody test results in patients with ocular myasthenia gravis.

This study characterized the clinical, structural, electrophysiologic, and genetic features of a congenital myasthenic syndrome, identified the disease gene and mutation, confirmed pathogenicity of the mutation by expression studies, and instituted optimal pharmacotherapy.

This Special Communication reports on the latest research in myasthenia, which results from dysfunction of the neuromuscular synapse (ie, the neuromuscular junction), causing clinical “fatigue” that is defined as muscle weakness that worsens with muscle use and improves with rest.