Explore the latest in nail disorders, including nail changes as signs of systemic disease and drug reactions.
A man in his 40s presented to the dermatology clinic for evaluation of a dark brown longitudinal pigment band covering his left second toenail; the lesion appeared 12 months prior, had been growing, and was asymptomatic. What is your diagnosis?
This systematic review summarizes evidence on the effectiveness and safety of current cryotherapy methods to prevent hair, skin, and nail changes associated with chemotherapy.
This study assesses the rate and utility of monitoring laboratory test result abnormalities in adults and children taking terbinafine and griseofulvin for treatment of dermatophyte infections.
This case report describes the occurrence of onychomadesis in a patient following a fish pedicure.
This cohort study identifies the dermoscopic features of subungual melanoma in situ in a Korean population and assesses a predictive scoring model that distinguishes the diagnosis of subungual melanoma in situ from longitudinal melanonychia in patients with pigmented nails.
This secondary analysis of 2 randomized clinical trials evaluates the effect of guselkumab vs adalimumab or placebo on psoriasis in specific difficult-to-treat body regions.
This article argues that the physical examination finding of long toenails should alert the clinician to other possible care needs and help guide questions as to the underlying differential diagnosis of the untrimmed toenails.
A woman receiving immunosuppressant therapy after a prior kidney transplant presented with a tender ulcerated nodule on her fingernail with nail loss, purulent drainage, and histopathology showing a pyogenic granuloma–like response with atypical epithelioid and spindled cells adjacent to blood vessels. What would you do next?
This Clinical Evidence Synopsis summarizes a Cochrane review comparing the effectiveness and safety of oral antifungal medications for treatment of fungal toenail infection.
This study evaluated the efficacy and tolerability of topical timolol, 0.5%, gel as a treatment of paronychia and pseudopyogenic granuloma induced by antineoplastic agents.
This retrospective medical record review examines the prevalence of laboratory monitoring and laboratory abnormalities during systemic terbinafine therapy in pediatric onychomycosis.
This case report describes 2 persons with external thumbnail characteristics indicative of linear nail streak.
This cohort study examines the efficiency of wide surgical excision of the nail unit with full-thickness skin graft reconstruction for patients with subungual squamous cell carcinoma and evaluates short- and long-term postoperative morbidity and patient satisfaction.
This in vitro study examines intraoperative irrigation of the nail bed, comparing the effect of 3 aqueous solutions for the neutralization of phenol.
This case report describes resolution of nail changes of systemic amyloidosis after bone-marrow transplantation in a patient with multiple myeloma.
A 34-year-old woman has thickened toenails for more than 20 years, with subungual hyperkeratosis of all 10 toenails and scale on the plantar surface skin and in the web spaces on examination. What would you do next?
A man in his 70s presented with a split in the right fifth fingernail with paroxysmal, intermittent pain that was exacerbated by cold weather for the past 10 years. What is your diagnosis?
This study explores the potential for optical coherence tomography capillaroscopy of the nailfolds using dynamic optical coherence tomography.
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