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    Nail Disorders

    Explore the latest in nail disorders, including nail changes as signs of systemic disease and drug reactions.

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    • Botulinum Toxin A for the Treatment of Yellow Nail Syndrome and Palmar Primary Hyperhidrosis
      JAMA Dermatology
      Case Report
      October 1, 2022

      This case report describes a 23-year-old man with excessive sweating of the bilateral palms and 20 yellow nails.

      Dermatology Fungal Infections Infectious Diseases
      Full Text | pdf link PDF
    • Nail Sarcoidosis
      JAMA Dermatology
      Case Report
      October 1, 2022

      This case report describes significant longitudinal ridging and nail plate crumbling on several of a patient’s fingernails.

      Dermatology Images in Dermatology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • An 18-Year-Old Woman With Recurrent Skin, Nail, and Oral Mucosal Abnormalities
      JAMA
      Case Report
      September 20, 2022

      An 18-year-old woman had a 14-year history of recurrent skin, nail, and oral mucosal abnormalities, treated with 3- to 6-month courses of itraconazole; the abnormalities typically recurred within 6 to 12 months of discontinuing itraconazole. Skin scrapings from the lower extremities demonstrated fungal elements; fungal culture of the skin scrapings grew Candida albicans. What is the diagnosis and what would you do next?

      Allergy and Clinical Immunology Dermatology Otolaryngology Clinical Challenge Fungal Infections
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Pigmented Bowen Disease of the Nail Unit
      JAMA Dermatology
      Case Report
      August 1, 2022

      This case report describes a black and red, hyperkeratotic scaly thin plaque with irregular borders on the proximal and lateral nail folds of the right third toe.

      Images in Dermatology Dermatology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Usefulness of Noninvasive Management With the Gutter Method for Epidermal Growth Factor Receptor Inhibitor–Induced Paronychia, Pyogenic Granuloma–Like Lesion, and Ingrown Nail
      JAMA Dermatology
      Research
      May 1, 2022

      This case series investigates the characteristics of epidermal growth factor receptor inhibitor–induced nail changes and usefulness of the gutter method.

      Oncology Adverse Drug Events Targeted and Immune Cancer Therapy Dermatology Infectious Diseases
      Full Text | pdf link PDF
    • Treatment of Severe Nail Lichen Planus With Baricitinib
      JAMA Dermatology
      Case Report
      January 1, 2022

      This case report describes severe recalcitrant nail lichen planus that improved with the use of oral baricitinib.

      Dermatology
      Full Text | pdf link PDF
    • Content Analysis of Patient-Reported Outcome Measures Used in Patients With Nail Conditions: A Systematic Review
      JAMA Dermatology
      Research
      December 1, 2021

      This systematic review identifies and examines the content of nail-specific patient questionnaires to understand if some instruments may be better suited to measuring different research outcomes.

      Dermatology
      Full Text | pdf link PDF free
    • Prevalence and Characterization of Itch in Pachyonychia Congenita
      JAMA Dermatology
      Research
      November 1, 2021

      This survey study examines the prevalence and characteristics of itch in pachyonychia congenita.

      Dermatology Pediatrics Congenital Defects
      Full Text | pdf link PDF free
    • Tofacitinib as Treatment for Nail Lichen Planus Associated With Alopecia Universalis
      JAMA Dermatology
      Case Report
      March 1, 2021

      This case report describes opaque trachyonychia of all fingernails.

      Dermatology Hair Disorders
      Full Text | pdf link PDF
    • A Patient With Dizziness, Chest Pain, Rash, and Nail Changes
      JAMA
      Case Report
      January 5, 2021

      A 40-year-old woman with dizziness and imbalance, a petechial rash on her palms and soles, and a right thumbnail splinter hemorrhage had acute right cerebellar infarcts with a left atrial mass on CT angiogram. What is the diagnosis and what would you do next?

      Valvular Heart Disease Clinical Challenge Neurology Stroke Dermatology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Spectrum of Nail Sequelae in Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
      JAMA Dermatology
      Research
      January 1, 2021

      This case series documents the incidence of various nail changes as sequalae to Stevens-Johnson syndrome/toxic epidermal necrolysis.

      Dermatology Cutaneous Drug Reactions Adverse Drug Events Allergy and Clinical Immunology
      Full Text | pdf link PDF free
    • Dyschromic Nails, Exertional Dyspnea, and Lower Extremity Edema
      JAMA
      Case Report
      November 17, 2020

      A 70-year-old man with a 2-year history of nasal congestion, rhinorrhea, and chronic cough developed yellow discoloration and thickening of his fingernails and toenails and progressive exertional dyspnea and edema of both lower extremities. ANA was positive (1:160, nucleolar pattern), a chest radiograph was unrevealing, and sinus CT showed bilateral maxillary and posterior ethmoidal sinusitis. What is the diagnosis and what would you do next?

      Dermatology Otolaryngology Pulmonary Medicine Rhinology Clinical Challenge
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Bart-Pumphrey Syndrome
      JAMA Dermatology
      Case Report
      October 1, 2020

      This case report describes a young man with Bart-Pumphrey syndrome, a rare genetic disorder affecting both the skin of the hands and the hearing.

      Otolaryngology Audiology and Hearing Images in Dermatology Dermatology
      Full Text | pdf link PDF
    • Erythematous Nodule With Central Crust on the Nail Fold in an Infant
      JAMA Dermatology
      Case Report
      September 1, 2020

      A girl younger than 2 years presented with a 7-month history of an inflammatory plaque with a central shiny orange crust on her left index finger and no improvement with empiric therapy. What is your diagnosis?

      Infectious Diseases Pediatrics Clinical Challenge Dermatology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Oral and Topical Terbinafine for Fungal Infections in Pregnancy
      JAMA Dermatology
      Opinion
      April 1, 2020
      Congenital Defects Dermatology Fungal Infections Infectious Diseases Pediatrics
      Full Text | pdf link PDF
    • Evaluation of Association Between Oral and Topical Terbinafine Use in Pregnancy and Risk of Major Malformations and Spontaneous Abortion
      JAMA Dermatology
      Research
      April 1, 2020

      This cohort study examines the association between use of oral or topical terbinafine and malformations and spontaneous abortions in women who receive terbinafine during pregnancy.

      Dermatology Pregnancy Antenatal Exposures and Child Outcomes Obstetrics Pharmacoepidemiology
      Full Text | pdf link PDF free
    • Exogenous Pigmentation Presenting as Longitudinal Melanonychia in a Child
      JAMA Dermatology
      Case Report
      January 1, 2020

      This case report describes an 8-year-old girl who presented with a linear pigmented band on the nail of her right middle finger.

      Dermatology Pediatrics
      Full Text | pdf link PDF
    • A Case of Pigmented Longitudinal Melanonychia
      JAMA Dermatology
      Case Report
      December 1, 2018

      A man in his 40s presented to the dermatology clinic for evaluation of a dark brown longitudinal pigment band covering his left second toenail; the lesion appeared 12 months prior, had been growing, and was asymptomatic. What is your diagnosis?

      Dermatology Clinical Challenge
      Full Text | pdf link PDF
    • Utility of Laboratory Test Result Monitoring in Patients Taking Oral Terbinafine or Griseofulvin for Dermatophyte Infections
      JAMA Dermatology
      Research
      December 1, 2018

      This study assesses the rate and utility of monitoring laboratory test result abnormalities in adults and children taking terbinafine and griseofulvin for treatment of dermatophyte infections.

      Fungal Infections Pathology and Laboratory Medicine Dermatology Skin Infections Pediatrics
      Full Text | pdf link PDF free
    • Evaluation of Prevention Interventions for Taxane-Induced Dermatologic Adverse Events: A Systematic Review
      JAMA Dermatology
      Review
      December 1, 2018

      This systematic review summarizes evidence on the effectiveness and safety of current cryotherapy methods to prevent hair, skin, and nail changes associated with chemotherapy.

      Oncology Dermatology Adverse Drug Events Hair Disorders Breast Cancer
      Full Text | pdf link PDF
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