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    Nephrology

    Explore the latest in nephrology, including recent guidelines and advances in the prevention and management of acute kidney injury and CKD.

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    • Forecasting of Patient-Specific Kidney Transplant Function With a Sequence-to-Sequence Deep Learning Model
      JAMA Network Open
      Research
      December 30, 2021

      This diagnostic study assesses whether a deep learning model could accurately predict the patient-specific expected reference range of estimated glomerular filtration rate after kidney transplant.

      Surgery Transplantation Health Informatics Renal Replacement
      Full Text | pdf link PDF open access
    • Association of Transit Time With Cold Ischemic Time in Kidney Transplantation
      JAMA Network Open
      Research
      December 23, 2021

      This cross-sectional study examines the association between transit time and cold ischemic time for adult, deceased kidney transplant donors.

      Surgery Transplantation Renal Replacement
      Full Text | pdf link PDF open access
    • Final Overall Survival and Molecular Analysis in IMmotion151, a Phase 3 Trial Comparing Atezolizumab Plus Bevacizumab vs Sunitinib in Patients With Previously Untreated Metastatic Renal Cell Carcinoma
      JAMA Oncology
      Research
      December 23, 2021

      This phase 3 randomized clinical trial reports the final overall survival, safety, and exploratory analyses of the association of transcriptomic subsets with overall survival from IMmotion151.

      Targeted and Immune Cancer Therapy Oncology Urology Urologic Cancer
      Full Text | pdf link PDF has multimedia
    • Comparison of SARS-CoV-2 Antibody Response 4 Weeks After Homologous vs Heterologous Third Vaccine Dose in Kidney Transplant Recipients: A Randomized Clinical Trial
      JAMA Internal Medicine
      Research
      December 20, 2021

      This randomized clinical trial evaluated the effectiveness of a third dose of mRNA-based vs a vector-based vaccine in 201 kidney transplant recipients with no SARS-CoV-2 antibodies after 2 prior doses of an mRNA vaccine.

      Vaccination Public Health Renal Replacement Coronavirus (COVID-19)
      Full Text | pdf link PDF open access
    • Evaluation of Daily Low-Dose Prednisolone During Upper Respiratory Tract Infection to Prevent Relapse in Children With Relapsing Steroid-Sensitive Nephrotic Syndrome: The PREDNOS 2 Randomized Clinical Trial
      JAMA Pediatrics
      Research
      December 20, 2021

      This randomized clinical trial investigates whether a low daily dose of prednisolone in children with relapsing steroid-sensitive nephrotic syndrome prevents upper respiratory tract infection–related relapse.

      Infectious Diseases Pediatrics
      Full Text | pdf link PDF open access
    • Coverage, Formulary Restrictions, and Affordability of Sodium-Glucose Cotransporter 2 Inhibitors by US Insurance Plan Types
      JAMA Health Forum
      Research
      December 17, 2021

      This cross-sectional study evaluates the stipulations of coverage under commercial, health insurance exchange, Veterans Affairs, Medicare, Medicaid, or other insurance for canagliflozin, dapagliflozin, empagliflozin, and ertugliflozin.

      Health Policy Diabetes Diabetes and Endocrinology Health Care Economics, Insurance, Payment
      Full Text | pdf link PDF open access
    • Severe Polyarthralgia After Kidney Transplant
      JAMA
      Case Report
      December 16, 2021

      A 51-year-old woman had intense and worsening polyarthralgia and swelling of bilateral fingers and toes 1 year after kidney transplant complicated by Volvariella volvacea infection of the central nervous system. Her medications included tacrolimus, prednisolone, cinacalcet, and voriconazole. Alkaline phosphatase level was elevated, and radiography of the hands revealed periostitis. What is the diagnosis and what would you do next?

      Rheumatology Transplantation Renal Replacement Clinical Challenge Fungal Infections
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Association of Social Risk Factors With Home Dialysis and Kidney Transplant Rates in Dialysis Facilities
      JAMA
      Research
      December 14, 2021

      This study examines rates of home dialysis and transplant at dialysis facilities that serve patients with high social risk to understand how they fare under the End-Stage Renal Disease Treatment Choices Model.

      Health Disparities Surgery Transplantation Health Inequities Diversity, Equity, and Inclusion
      Full Text | pdf link PDF
    • Association of Differences in Treatment Intensification, Missed Visits, and Scheduled Follow-up Interval With Racial or Ethnic Disparities in Blood Pressure Control
      JAMA Cardiology
      Research
      December 8, 2021

      This cohort study assesses whether and to what extent differences in treatment intensification, scheduled follow-up interval, and missed visits are associated with racial and ethnic disparities in blood pressure control among adults with hypertension.

      Cardiology Chronic Kidney Disease Electronic Health Records Heart Failure Hypertension
      Full Text | pdf link PDF has multimedia
    • Treatment Intensification and Missed Visits as Important Targets for Reducing Racial and Ethnic Disparities in Hypertension Control
      JAMA Cardiology
      Opinion
      December 8, 2021
      Chronic Kidney Disease Electronic Health Records Hypertension Diversity, Equity, and Inclusion Health Disparities
      Full Text | pdf link PDF has multimedia
    • Perceptions of Telehealth vs In-Person Visits Among Older Adults With Advanced Kidney Disease, Care Partners, and Clinicians
      JAMA Network Open
      Research
      December 6, 2021

      This qualitative study identifies patient, care partner, and clinicians’ perceptions of the patient-centeredness, benefits, and drawbacks of telehealth compared with in-person visits.

      Geriatrics Health Care Delivery Models Mobile Health and Telemedicine Chronic Kidney Disease
      Full Text | pdf link PDF open access
    • Communication and Remote Care Delivery for an Aging Population With Kidney Disease
      JAMA Network Open
      Opinion
      December 6, 2021
      Geriatrics Chronic Kidney Disease Mobile Health and Telemedicine Health Care Delivery Models
      Full Text | pdf link PDF open access
    • Interleukin 6 and Cardiovascular Outcomes in Patients With Chronic Kidney Disease and Chronic Coronary Syndrome
      JAMA Cardiology
      Research
      December 1, 2021

      This cohort study outlines the associations and interactions between interleukin 6, chronic kidney disease, and the risk of major cardiovascular outcomes in patients with chronic coronary syndrome.

      Chronic Kidney Disease Ischemic Heart Disease Cardiology
      Full Text | pdf link PDF
    • Clinical Activity and Safety of Cabozantinib for Brain Metastases in Patients With Renal Cell Carcinoma
      JAMA Oncology
      Research
      December 1, 2021

      This cohort study assesses the clinical activity and toxic effects of cabozantinib to treat brain metastases in patients with metastatic renal cell carcinoma.

      Neuro-oncology Neurology Targeted and Immune Cancer Therapy Oncology Urology
      Full Text | pdf link PDF
    • Evaluation of Community-Level Vulnerability and Racial Disparities in Living Donor Kidney Transplant
      JAMA Surgery
      Research
      December 1, 2021

      This cross-sectional study evaluates if racial disparities persist in living donor kidney transplant independent of community-level vulnerability.

      Surgery Transplantation Health Disparities Renal Replacement Diversity, Equity, and Inclusion
      Full Text | pdf link PDF has multimedia
    • Structural Barriers to African American Living Donor Kidney Transplant
      JAMA Surgery
      Opinion
      December 1, 2021
      Health Disparities Surgery Transplantation Health Inequities Renal Replacement
      Full Text | pdf link PDF
    • Arteriovenous Fistula Maturation, Functional Patency, and Intervention Rates
      JAMA Surgery
      Research
      December 1, 2021

      This case series examines the usability of autogenous arteriovenous fistulas for hemodialysis in patients with chronic kidney disease and kidney failure.

      Surgery Vascular Surgery Renal Replacement Chronic Kidney Disease
      Full Text | pdf link PDF
    • Building Systems to Measure Success and Improve Outcomes in Dialysis Access—Not a “Steal” but Probably a Bargain
      JAMA Surgery
      Opinion
      December 1, 2021
      Surgery Vascular Surgery Renal Replacement
      Full Text | pdf link PDF
    • A Boy With Anterior Uveitis and Optic Disc Swelling
      JAMA Ophthalmology
      Case Report
      December 1, 2021

      A 14-year-old boy had ocular and periocular pain with photophobia in his right eye. Routine blood tests showed a serum creatinine level of 1.57 mg/dL. What would you do next?

      Pediatrics Clinical Challenge Intraocular Inflammation Ophthalmology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Early-Onset Kidney Stone Disease—Consequences and Opportunities
      JAMA Pediatrics
      Opinion
      December 1, 2021

      This Viewpoint discusses the increasing incidence of early-onset kidney stone disease, its epidemiology and consequences, and the need for more data to inform treatment decisions.

      Urology
      Full Text | pdf link PDF
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