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    Neuro-oncology

    Explore the latest in neuro-oncology, including advances in diagnosis and management of glial tumors, CNS lymphomas, and CNS metastases.

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    • Challenges and Opportunities for Clinical Trials in Patients With Glioma
      JAMA Neurology
      Opinion
      March 1, 2023

      This Viewpoint discusses the challenges and opportunities of including patients with glioma in clinical trials.

      Neurology Oncology Research, Methods, Statistics
      Full Text | pdf link PDF
    • Glioblastoma and Other Primary Brain Malignancies in Adults: A Review
      JAMA
      Review
      February 21, 2023

      This review summarizes current evidence regarding diagnosis and treatment of primary malignant brain tumors in adults.

      Neurology Oncology
      Full Text | pdf link PDF | CME & MOC is active quiz has multimedia
    • Agent Slows Glioblastoma Tumors in Mice by Blocking Fat Metabolism
      JAMA
      News
      February 21, 2023
      Neurology Targeted and Immune Cancer Therapy Oncology
      Full Text | pdf link PDF
    • Assessment of Social Vulnerability in Pediatric Head and Neck Cancer Care and Prognosis in the United States
      JAMA Network Open
      Research
      February 17, 2023

      This cohort study evaluates the association of overall social vulnerability and specific social determinants of health with disparities in head and neck cancer care and prognosis among children and adolescents in the United States.

      Oncology Pediatric Cancer Pediatrics Surgery Surgical Oncology
      Full Text | pdf link PDF open access
    • Assessment of Phase 3 Randomized Clinical Trials Including Patients With Leptomeningeal Disease: A Systematic Review
      JAMA Oncology
      Research
      February 9, 2023

      This systematic review examines the proportion of patients with leptomeningeal disease included in phase 3 randomized clinical trials for patients with metastatic breast cancer, lung cancer, and melanoma.

      Breast Cancer Neurology Oncology Women's Health Lung Cancer
      Full Text | pdf link PDF
    • Gefitinib Plus Chemotherapy vs Gefitinib Alone in Untreated EGFR -Mutant Non–Small Cell Lung Cancer in Patients With Brain Metastases: The GAP BRAIN Open-Label, Randomized, Multicenter, Phase 3 Study
      JAMA Network Open
      Research
      February 8, 2023

      This randomized clinical trial compares the use of gefitinib plus chemotherapy with gefitinib monotherapy in patients with untreated EGFR-mutant non–small cell lung cancer brain metastases.

      Oncology Cancer Genetics Cancer Biomarkers Genetics and Genomics Lung Cancer
      Full Text | pdf link PDF open access
    • Tucatinib vs Placebo, Both in Combination With Trastuzumab and Capecitabine, for Previously Treated ERBB2 (HER2)-Positive Metastatic Breast Cancer in Patients With Brain Metastases: Updated Exploratory Analysis of the HER2CLIMB Randomized Clinical Trial
      JAMA Oncology
      Research
      February 1, 2023

      This subgroup analysis of a randomized clinical trial investigates whether tucatinib in combination with trastuzumab and capecitabine provides survival and intracranial benefits for patients with ERBB2-positive metastatic breast cancer and brain metastases.

      Neurology Targeted and Immune Cancer Therapy Oncology Women's Health Breast Cancer
      Full Text | pdf link PDF open access
    • Effect of Oral β-Glucan on Antibody Response to Ganglioside Vaccine in Patients With High-Risk Neuroblastoma: A Phase 2 Randomized Clinical Trial
      JAMA Oncology
      Research
      February 1, 2023

      This phase 2 randomized clinical trial evaluates the effect of β-glucan administered during vaccine priming on antibody titer and seroconversion rates at a large cancer center in children with high-risk neuroblastoma.

      Pediatric Cancer Genetics and Genomics Neurology Oncology Pediatrics
      Full Text | pdf link PDF
    • Adjuvant Temozolomide Chemotherapy With or Without Interferon Alfa Among Patients With Newly Diagnosed High-grade Gliomas: A Randomized Clinical Trial
      JAMA Network Open
      Research
      January 27, 2023

      This randomized clinical trial evaluates the efficacy of the combination of temozolomide with interferon alfa in patients with newly diagnosed high-grade glioma.

      Oncology Surgery Neurology Neurosurgery Pharmacy and Clinical Pharmacology
      Full Text | pdf link PDF open access
    • Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients With Newly Diagnosed and Recurrent Glioblastoma: A Phase 3 Prospective Externally Controlled Cohort Trial
      JAMA Oncology
      Research
      January 1, 2023

      This nonrandomized controlled trial investigates whether adding autologous tumor lysate-loaded dendritic cell vaccine (DCVax-L) to standard of care extends survival among patients with newly diagnosed or recurrent glioblastoma.

      Neurology Oncology Targeted and Immune Cancer Therapy
      Full Text | pdf link PDF open access has multimedia
    • Anti-LGI1–Associated Myopathy in the Setting of Neuromuscular Hyperexcitability Syndrome
      JAMA Neurology
      Case Report
      December 1, 2022

      This case report describes a patient with anti–leucine-rich glioma-inactivated 1 (LGI1)–associated hyperexcitability syndrome associated with myopathy.

      Neurology Oncology Images in Neurology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Pooled Analysis of Meningioma Risk Following Treatment for Childhood Cancer
      JAMA Oncology
      Research
      December 1, 2022

      This case-control study evaluates meningioma risk following radiotherapy and chemotherapy and identifies possible factors associated with modifying radiation-associated risk in survivors of childhood cancer.

      Oncology Cancer Epidemiology Cancer Survivorship Neurology Soft-Tissue Tumors
      Full Text | pdf link PDF open access
    • Association of Long-term Outcomes With Stereotactic Radiosurgery vs Whole-Brain Radiotherapy for Resected Brain Metastasis: A Secondary Analysis of The N107C/CEC.3 (Alliance for Clinical Trials in Oncology/Canadian Cancer Trials Group) Randomized Clinical Trial
      JAMA Oncology
      Research
      December 1, 2022

      This secondary analysis examines the long-term association of whole-brain radiotherapy and stereotactic radiosurgery with quality of life and cognition outcomes for patients with limited brain metastasis following surgical resection.

      Neurology Surgery Surgical Oncology Oncology Radiation Oncology
      Full Text | pdf link PDF
    • Safety of Withholding Perioperative Hydrocortisone for Patients With Pituitary Adenomas With an Intact Hypothalamus-Pituitary-Adrenal Axis: A Randomized Clinical Trial
      JAMA Network Open
      Research
      November 16, 2022

      This randomized clinical trial assesses the safety of withholding perioperative hydrocortisone during the perioperative period of pituitary adenoma surgery for patients with an intact hypothalamus-pituitary-adrenal axis.

      Surgery Perioperative Care and Consultation Endocrine Surgery Endocrinology Diabetes and Endocrinology
      Full Text | pdf link PDF open access
    • Ophthalmological Findings in Youths With a Newly Diagnosed Brain Tumor
      JAMA Ophthalmology
      Research
      October 1, 2022

      This cohort study assesses the prevalence and types of visual symptoms and abnormal ophthalmological findings in Dutch youths with a newly diagnosed brain tumor.

      Pediatric Cancer Neuro-ophthalmology Oncology Ophthalmology Pediatrics
      Full Text | pdf link PDF
    • World Health Organization 2021 Classification of Central Nervous System Tumors and Implications for Therapy for Adult-Type Gliomas: A Review
      JAMA Oncology
      Review
      October 1, 2022

      This narrative review discusses the implications of the 2021 updates to the World Health Organization (WHO) central nervous system (CNS) tumor classification relative to adult-type glioma diagnosis, prognosis, and treatment.

      Neurology Oncology Global Health
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Discordance Between Oncology Clinician–Perceived and Radiologist-Intended Meaning of the Postradiotherapy Positron Emission Tomography/Computed Tomography Freeform Report for Head and Neck Cancer
      JAMA Otolaryngology–Head & Neck Surgery
      Research
      October 1, 2022

      This cohort study examines clinician-perceived freeform report meaning and discordance with nuclear medicine interpretation using the modified Deauville score.

      Head and Neck Cancer Neurology Oncology Otolaryngology Radiation Oncology
      Full Text | pdf link PDF
    • Brain Metastasis—A Distinct Oncologic Disease Best Served by an Integrated Multidisciplinary Team Approach
      JAMA Oncology
      Opinion
      September 1, 2022

      This Viewpoint discusses the identification and treatment of brain metastasis as a distinct disease and its management with a multidisciplinary approach to improve patient outcomes.

      Neurology Neurosurgery Oncology Surgery
      Full Text | pdf link PDF
    • Outcomes and Molecular Features of Brain Metastasis in Gastroesophageal Adenocarcinoma
      JAMA Network Open
      Research
      August 24, 2022

      This cohort study characterizes the clinical and genomic features of patients with brain metastasis from gastroesophageal adenocarcinoma and evaluates the associations of surgical resection and radiotherapy use with survival.

      Oncology Genetics and Genomics Neurology Cancer Biomarkers Surgery
      Full Text | pdf link PDF open access
    • Extent of Tumor Resection and Survival in Pediatric Patients With High-Grade Gliomas: A Systematic Review and Meta-analysis
      JAMA Network Open
      Research
      August 16, 2022

      This systematic review and meta-analysis describes postoperative outcomes associated with gross total resection, subtotal resection, and biopsy in children with high-grade gliomas.

      Oncology Pediatric Cancer Neurology Neurosurgery Surgery
      Full Text | pdf link PDF open access
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