Explore the latest in neuropathies, including diagnosis and management of patients with hereditary, acquired, and idiopathic forms.
This open-label, single-group, phase 3 trial evaluates eplontersen, an investigational ligand-conjugated antisense oligonucleotide, in adults with hereditary amyloid transthyretin (ATTRv) polyneuropathy at 40 sites in 15 countries, compared with historical controls.
This cross-sectional study examines the use of quantitative sensory testing to characterize somatosensory profiles among patients with hidradenitis suppurativa at clinically affected and nonaffected sites.
This case report describes a 63-year-old man who developed dysesthesia in his feet and was misdiagnosed with chronic inflammatory demyelinating polyradiculoneuropathy.
This secondary analysis compared the effect of a 6-month aerobic exercise intervention vs attention control for chemotherapy-induced peripheral neuropathy (CIPN) among participants in the Women’s Activity and Lifestyle Study in Connecticut trial who received chemotherapy for ovarian cancer.
A previously healthy individual in his 20s had 3 months of annular skin lesions, with numbness and paresthesia in the affected areas. Physical examination revealed multiple tattoos, bilateral palpable thickened auricular and ulnar nerves, and claw-hand deformity; test results for rapid plasma reagin, antinuclear antibodies, rheumatoid factor, acid-fast bacilli, mycobacteria, and fungi were negative, and biopsy did not identify Mycobacterium leprae. What is the diagnosis and what would you do next?
This cohort study investigates the association of carpal tunnel syndrome with heart failure among a large group of outpatients in Germany.
A 60-year-old patient with a history of lumbar spinal stenosis had 2 months of chest pain and shortness of breath with exertion and 3 months of toe numbness. Laboratory testing showed elevated levels of high-sensitivity troponin, brain-type natriuretic peptide, aspartate aminotransferase, and alanine aminotransferase; bone scintigraphy showed increased cardiac uptake. What is the diagnosis and what would you do next?
This Review summarizes current evidence regarding the epidemiology, pathophysiology, diagnosis, treatment, and prevention of diabetic foot ulcers.
This remote randomized clinical trial compares a mind-body skills training program with a health education program for improvement of quality of life among adults with neurofibromatosis.
This randomized clinical trial evaluates the use of topical esmolol hydrochloride combined with standard of care treatment vs standard care alone in patients with diabetic foot ulcers.
This JAMA Patient Page describes the autoimmune disease Guillain-Barré syndrome and its risk factors, diagnosis, treatment, and prognosis.
This economic evaluation assesses the cost-effectiveness of an ON101 cream added on to general wound care vs general wound care alone for diabetic foot ulcers (DFUs) from the Taiwan health care sector perspective.
This randomized clinical trial evaluates the noninferiority of posterior surgery to anterior surgery for outcomes in patients with cervical radiculopathy at 1 year.
This systematic review and meta-analysis assesses blood-based biomarker concentrations associated with nerve involvement in patients with peripheral neuropathy compared with control participants.
A 15-year-old adolescent girl taking an oral contraceptive had 3 days of pain in a 1-cm area of the lower left abdominal quadrant. She had no nausea/vomiting, diarrhea, hematochezia, bloating, or anorexia; no precipitating factors for the pain; and no history of pregnancy, abdominal surgery, or abdominal trauma. Results from laboratory tests, endoscopy, and abdominal computed tomography were normal. What is the diagnosis and what would you do next?
This cohort study compares the symptom spectrum of patient-reported chemotherapy-induced peripheral neuropathy associated with nab-paclitaxel, paclitaxel, and docetaxel treatments among patients with breast cancer.
This case report describes neurogenic unilateral leg edema that was a consequence of chronic regional pain syndrome induced by an S1 radiculopathy.
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