Nevi

This cohort study performs targeted next-generation sequencing on a cohort of acral nevi to determine their mutational spectrum.

We present a case of extensive and aggressively recurrent facial agminated Spitz nevi associated with a GOPC-ROS1 kinase fusion and the response to systemic treatment with crizotinib.

A man in his 60s presents with a 5-year history of pruritic papules on his lower back. Physical examination results show multiple dome-shaped, skin-colored, firm papules arranged in a blaschkoid distribution. Telangiectasis could be seen on some of the lesions. A skin biopsy is performed and submitted for further histopathologic analysis. What is your diagnosis?

A woman in her early 70s presents with a solitary, asymptomatic lump on her scalp; the lesion was yellow, firm, and mildly tender to the touch. What is your diagnosis?

A girl in her teens presented with punctate keratotic papules on the palm and third finger, which had been present since the age of 2 years. What is your diagnosis?

This phase 2, open-label, placebo-controlled examines topical itraconazole as a treatment for basal cell carcinoma.

This case report describes a somatic p.Phe29del mutation of the connexin 26 gene (GJB2) manifesting as acantholytic dyskeratotic epidermal nevus.

This multicenter cohort study examines the outcomes and risk for the development of subsequent cutaneous melanoma in moderately dysplastic nevi excisionally biopsied without residual clinical pigmentation but with positive histologic margins, observed for 3 years or more.

This database study evaluated the efficacy of monitoring flat symmetric pigmented spitzoid-looking lesions in prepubertal children.

This longitudinal cohort study describes nevus acquisition from the ages of 3 to 16 years among white youths and evaluates variation by sex, Hispanic ethnicity, and body sites that are chronically vs intermittently exposed to the sun.

This study of 87 pathologists compares the use of digital whole-slide imaging vs traditional microscopy in pathologists’ ability to accurately interpret melanocytic lesions and reproduce correct diagnoses.

This report of cases describes the use of picosecond laser to treat acquired bilateral nevus of Ota–like macules.

A woman in her 20s presented with linear hyperkeratotic papules on her right arm in a Blaschkoid pattern. What is your diagnosis?

This large-scale analysis of pathology reports in electronic medical records, using the natural language processing technique, evaluates population-based distributions and pathologic characteristics of melanocytic proliferations.

This cohort study from the Study of Nevi in Children examines host, behavioral, and dermoscopic factors in early adolescence that are associated with a mole-prone phenotype in late adolescence.

This case report describes induction of immune reaction to benign melanocytic nevi without halo during nivolumab therapy in a patient with melanoma.