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    Nevi

    Explore the latest in nevi, including recent advances in imaging and in understanding risk for transformation to melanoma.

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    • Pathologist Characteristics Associated With Rendering Higher-Grade Diagnoses for Melanocytic Lesions
      JAMA Dermatology
      Research
      November 8, 2023

      This exploratory study examines characteristics of pathologists that are associated with likelihood of diagnosing melanocytic lesions as higher grade or invasive melanoma vs a less severe diagnosis.

      Pathology and Laboratory Medicine Oncology Skin Cancer Dermatology Melanoma
      Full Text | pdf link PDF has multimedia
    • Perspectives and Strategies to Minimize Harm From Melanoma Diagnosis
      JAMA Dermatology
      Opinion
      November 8, 2023
      Oncology Skin Cancer Pathology and Laboratory Medicine Dermatology Melanoma
      Full Text | pdf link PDF
    • Advances in Melanoma-Nevus Classification Using Artificially Generated Image Data Sets
      JAMA Dermatology
      Opinion
      November 1, 2023
      Dermatology Oncology Skin Cancer Health Informatics Melanoma
      Full Text | pdf link PDF
    • Generation of a Melanoma and Nevus Data Set From Unstandardized Clinical Photographs on the Internet
      JAMA Dermatology
      Research
      November 1, 2023

      This diagnostic study builds synthetic data sets for diagnosing melanoma and melanocytic nevus with artificial intelligence (AI) using unstandardized photographs on the internet.

      Dermatology Oncology Skin Cancer Melanoma Health Informatics
      Full Text | pdf link PDF
    • Acquired Melanocytic Nevi Mimicking Acral Lentiginous Melanoma in a Patient Taking a BRAF Inhibitor
      JAMA Dermatology
      Case Report
      October 1, 2023

      This case report describes a patient in their 60s with metastatic colon cancer who developed multiple new dark nevi within 2 months of initiating encorafenib and panitumumab therapy.

      Cutaneous Drug Reactions Targeted and Immune Cancer Therapy Oncology Melanoma Dermatology
      Full Text | pdf link PDF
    • Multiple Iris Nevi in an Eye With Ciliochoroidal Melanoma
      JAMA Ophthalmology
      Case Report
      September 21, 2023

      This case report discusses a diagnosis of ciliochoroidal melanoma in a patient with multiple iris nevi.

      Dermatology Melanoma Oncology Skin Cancer Ophthalmic Images
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Eruptive Acral Nevi Secondary to Treatment With Chemotherapy
      JAMA Dermatology
      Case Report
      July 1, 2023

      This case report describes an eruption of junctional nevi on the dorsum of both feet.

      Pediatric Cancer Hematology Oncology Pediatrics Hematologic Cancer
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Assessment of Diagnostic Performance of Dermatologists Cooperating With a Convolutional Neural Network in a Prospective Clinical Study: Human With Machine
      JAMA Dermatology
      Research
      June 1, 2023

      This prospective diagnostic study assesses whether dermatologists benefit from cooperation with a market-approved CNN in classifying melanocytic lesions

      Dermatology Melanoma Health Informatics Pathology and Laboratory Medicine
      Full Text | pdf link PDF
    • CLOVES Syndrome
      JAMA Dermatology
      Case Report
      June 1, 2023

      This case report describes an infant with large capillary malformations on the trunk, edematous left axilla and upper arm with loose skin and subcutaneous soft tissue tumors, and bilateral overgrowth of the feet with syndactyly of toes.

      Dermatology Images in Dermatology Cutaneous Vascular Malformations Soft-Tissue Tumors Oncology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Unusual Basal Cell Carcinoma in an Adult Woman With Gorlin-Goltz Syndrome
      JAMA Ophthalmology
      Case Report
      May 19, 2022

      This case report describes a woman with a history of Gorlin-Goltz syndrome who presented with a medial canthal mass of the left eye.

      Congenital Defects Dermatology Genetics and Genomics Oncology Pediatrics
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Multiple Craniofacial Nodules and Plaques Distributed Bilaterally Along Blaschko Lines
      JAMA Dermatology
      Case Report
      February 1, 2022

      A male in his late teens presented with asymptomatic congenital papules, plaques, and nodules in a linear bilateral distribution following Blaschko lines on the scalp and face region. What is your diagnosis?

      Dermatology Hair Disorders Clinical Challenge Adolescent Medicine Pediatrics
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Two Trajectories to Melanoma on the Hands and Feet
      JAMA Dermatology
      Opinion
      July 1, 2021
      Oncology Skin Cancer Cancer Genetics Dermatology Genetics and Genomics
      Full Text | pdf link PDF
    • A Mutational Survey of Acral Nevi
      JAMA Dermatology
      Research
      July 1, 2021

      This cohort study performs targeted next-generation sequencing on a cohort of acral nevi to determine their mutational spectrum.

      Cancer Genetics Dermatology Skin Cancer Melanoma
      Full Text | pdf link PDF
    • Evaluation of Crizotinib Treatment in a Patient With Unresectable GOPC-ROS1 Fusion Agminated Spitz Nevi
      JAMA Dermatology
      Research
      July 1, 2021

      We present a case of extensive and aggressively recurrent facial agminated Spitz nevi associated with a GOPC-ROS1 kinase fusion and the response to systemic treatment with crizotinib.

      Targeted and Immune Cancer Therapy Dermatology Genetics and Genomics Pediatrics
      Full Text | pdf link PDF
    • Skin-Colored Papules on the Right Lower Back of an Elderly Man
      JAMA Dermatology
      Case Report
      June 1, 2021

      A man in his 60s presents with a 5-year history of pruritic papules on his lower back. Physical examination results show multiple dome-shaped, skin-colored, firm papules arranged in a blaschkoid distribution. Telangiectasis could be seen on some of the lesions. A skin biopsy is performed and submitted for further histopathologic analysis. What is your diagnosis?

      Dermatology Clinical Challenge
      Full Text | pdf link PDF | CME & MOC is active quiz
    • A Solitary Lump on the Scalp
      JAMA Dermatology
      Case Report
      December 1, 2020

      A woman in her early 70s presents with a solitary, asymptomatic lump on her scalp; the lesion was yellow, firm, and mildly tender to the touch. What is your diagnosis?

      Clinical Challenge Dermatology Pathology and Laboratory Medicine Neurology Pediatrics
      Full Text | pdf link PDF
    • Punctate Keratotic Papules on the Palm
      JAMA Dermatology
      Case Report
      November 1, 2019

      A girl in her teens presented with punctate keratotic papules on the palm and third finger, which had been present since the age of 2 years. What is your diagnosis?

      Dermatology Clinical Challenge
      Full Text | pdf link PDF
    • Topical Itraconazole for the Treatment of Basal Cell Carcinoma in Patients With Basal Cell Nevus Syndrome or High-Frequency Basal Cell Carcinomas: A Phase 2, Open-Label, Placebo-Controlled Trial
      JAMA Dermatology
      Research
      September 1, 2019

      This phase 2, open-label, placebo-controlled examines topical itraconazole as a treatment for basal cell carcinoma.

      Dermatology Oncology Skin Cancer
      Full Text | pdf link PDF free
    • A Somatic p.Phe29del Mutation of Connexin 26 ( GJB2 ) Manifesting as Acantholytic Dyskeratotic Epidermal Nevus
      JAMA Dermatology
      Case Report
      May 1, 2019

      This case report describes a somatic p.Phe29del mutation of the connexin 26 gene (GJB2) manifesting as acantholytic dyskeratotic epidermal nevus.

      Dermatology
      Full Text | pdf link PDF
    • Observation of Moderately Dysplastic Nevi With Positive Margins: Are We There Yet?
      JAMA Dermatology
      Opinion
      December 1, 2018
      Dermatology Skin Cancer
      Full Text | pdf link PDF
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