[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 34.226.208.185. Please contact the publisher to request reinstatement.
HomeJN LearningSubscribeAppsJobs

Journals

JAMAJAMA Network OpenJAMA CardiologyJAMA DermatologyJAMA Facial Plastic SurgeryJAMA Internal MedicineJAMA NeurologyJAMA OncologyJAMA OphthalmologyJAMA Otolaryngology–Head & Neck SurgeryJAMA PediatricsJAMA PsychiatryJAMA SurgeryArchives of Neurology & Psychiatry (1919-1959)
JN LearningSubscribeAppsJobsInstitutions / LibrariansReprints & Permissions
Terms of Use | Privacy Policy | Accessibility Statement
2019 American Medical Association. All Rights Reserved
JAMA Network Home
JAMA Network
Sign In
Individual Sign In
Sign inCreate an Account
    [Skip to Content Landing]

    Targeted and Immune Cancer Therapy

    Explore the latest in targeted and immune therapies, including recent advances in precision therapies and in use of tumor checkpoint inhibitors.

    Add to Your Interests
     
    Journal
    All Journals
    Apply
    Article Type
    All Article Types
    Apply
    • Long-term Survival and Cost-effectiveness Associated With Axicabtagene Ciloleucel vs Chemotherapy for Treatment of B-Cell Lymphoma
      JAMA Network Open
      Research
      February 22, 2019

      This survival and cost-effectiveness analysis study uses survival curves from the ZUMA-1 trial (Safety and Efficacy of KTE-C19 in Adults With Refractory Aggressive Non-Hodgkin Lymphoma) to estimate long-term survival and cost-effectiveness associated with axicabtagene ciloleucel, a chimeric antigen receptor T-cell therapy, vs chemotherapy for treatment of relapsed or refractory B-cell lymphoma in adults.

      Immunology Oncology Clinical Pharmacy and Pharmacology Allergy and Clinical Immunology Hematology
      Full Text | pdf link PDF open access
    • First-line Nivolumab Plus Ipilimumab vs Sunitinib for Metastatic Renal Cell Carcinoma: A Cost-effectiveness Analysis
      JAMA Oncology
      Research
      February 21, 2019

      This cost-effectiveness analysis compares nivolumab plus ipilimumab vs sunitinib to examine whether the drug combination is cost-effective from a US payer perspective as a first-line treatment for intermediate- and poor-risk patients with metastatic renal cell carcinoma.

      Oncology Pharmacoeconomics Nephrology Urology Urologic Cancer
      Full Text | pdf link PDF
    • Safety and Efficacy of Immune Checkpoint Inhibitor Therapy in Patients With HIV Infection and Advanced-Stage Cancer: A Systematic Review
      JAMA Oncology
      Review
      February 7, 2019

      This systematic review examines the association of immune checkpoint inhibitor therapy with immune-related adverse effects, antitumor activity, and viral load in patients with HIV infection and advanced-stage cancer.

      HIV Oncology Lung Cancer Melanoma
      Full Text | pdf link PDF
    • Clinical Characterization of Immunotherapy-Related Pruritus Among Patients Seen in 2 Oncodermatology Clinics
      JAMA Dermatology
      Research
      February 1, 2019

      This cohort study assesses self-reported quality of life among patients referred to oncodermatology clinics for pruritus associated with immunotherapy.

      Oncology Adverse Drug Events Dermatology Clinical Pharmacy and Pharmacology
      Full Text | pdf link PDF
    • Bilateral Lower Extremity Skin Eruptions in an HIV-Positive Man Receiving Pembrolizumab Monotherapy for Non–Small Cell Lung Cancer
      JAMA Oncology
      Case Report
      February 1, 2019

      An HIV-positive man in his 30s being treated with pembrolizumab for metastatic programmed cell death ligand 1–positive squamous non–small cell lung cancer presents with pruritic, mildly painful, hyperpigmented papules and plaques on both feet. What is your diagnosis?

      Dermatology Clinical Challenge Oncology HIV Infectious Diseases
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Plasma vs Tissue Next-Generation Sequencing in Non–Small Cell Lung Cancer—Either, Both, or Neither?
      JAMA Oncology
      Opinion
      February 1, 2019
      Lung Cancer Oncology Cancer Genetics
      Full Text | pdf link PDF
    • Clinical Implications of Plasma-Based Genotyping With the Delivery of Personalized Therapy in Metastatic Non–Small Cell Lung Cancer
      JAMA Oncology
      Research
      February 1, 2019

      This study assesses whether plasma-based next-generation sequencing was associated with improved mutation detection and enhanced delivery of personalized therapy in a real-world clinical setting of patients with non–small cell lung cancer.

      Oncology Cancer Genetics Lung Cancer
      Full Text | pdf link PDF free
    • Survival Outcomes in Patients With Previously Untreated BRAF Wild-Type Advanced Melanoma Treated With Nivolumab Therapy: Three-Year Follow-up of a Randomized Phase 3 Trial
      JAMA Oncology
      Research
      February 1, 2019

      This follow-up of a randomized phase 3 trial compares the 3-year survival with nivolumab vs that with dacarbazine in patients with previously untreated BRAF wild-type advanced melanoma.

      Oncology Skin Cancer Melanoma
      Full Text | pdf link PDF
    • Safety and Efficacy of Durvalumab With or Without Tremelimumab in Patients With PD-L1–Low/Negative Recurrent or Metastatic HNSCC: The Phase 2 CONDOR Randomized Clinical Trial
      JAMA Oncology
      Research
      February 1, 2019

      This phase 2 randomized clinical trial compare the efficacy and toxicity profiles of durvalumab monotherapy and tremelimumab monotherapy against a combination of both in patients with recurrent or metastatic head and neck squamous cell carcinoma with low or no expression of programmed death ligand 1.

      Oncology Otolaryngology Head and Neck Cancer
      Full Text | pdf link PDF
    • Is Precision Medicine an Oxymoron?
      JAMA Oncology
      Opinion
      February 1, 2019

      This Viewpoint discusses the initials results of the NCI-MATCH trial, a phase 2 study that seeks to determine whether targeted therapies for specific gene mutations will lead to objective responses agnostic to the primary cancer type.

      Oncology Cancer Genetics
      Full Text | pdf link PDF
    • Rapidly Evolving Extensive Fluorodeoxyglucose-Positive Soft-Tissue Activity During Nivolumab Therapy
      JAMA Oncology
      Case Report
      January 24, 2019

      A 41-year-old woman with stage IIa melanoma of the upper thigh presented with diffuse erythematous induration of the upper thigh expanding to the lower left abdominal area and palpable subcutaneous nodules on the ipsilateral gluteal region and leg during nivolumab therapy. What is your diagnosis?

      Oncology Clinical Challenge Dermatology Clinical Pharmacy and Pharmacology Melanoma
      Full Text | pdf link PDF
    • Efficacy and Safety of Avelumab for Patients With Recurrent or Refractory Ovarian Cancer: Phase 1b Results From the JAVELIN Solid Tumor Trial
      JAMA Oncology
      Research
      January 24, 2019

      This phase 1b open-label study assesses the efficacy and safety of avelumab, an anti–programmed death ligand 1 agent, in a cohort of patients with previously treated recurrent or refractory ovarian cancer.

      Ovarian Cancer Gynecologic Cancer Gynecology Women's Health Obstetrics and Gynecology
      Full Text | pdf link PDF open access
    • Immunotherapy 2.0: Improving the Response to Checkpoint Inhibitors
      JAMA
      News
      January 15, 2019

      This Medical News article discusses the evolution of checkpoint inhibitor immunotherapies to improve efficacy and predict which patients will benefit the most.

      Oncology
      Full Text | pdf link PDF
    • Efficacy and Safety of Avelumab Treatment in Patients With Advanced Unresectable Mesothelioma: Phase 1b Results From the JAVELIN Solid Tumor Trial
      JAMA Oncology
      Research
      January 3, 2019

      This phase 1b clinical trial assesses the safety and efficacy of avelumab treatment in a multinational cohort of patients with unresectable, previously treated malignant mesothelioma.

      Oncology Pulmonary Medicine Lung Cancer
      Full Text | pdf link PDF open access
    • Association of Patient Sex With Efficacy of Immune Checkpoint Inhibitors and Overall Survival in Advanced Cancers: A Systematic Review and Meta-analysis
      JAMA Oncology
      Research
      January 3, 2019

      This systematic review and meta-analysis examine randomized clinical trials to assess whether immunotherapy treatments for advanced cancer are less effective in female patients.

      Oncology Lung Cancer Melanoma
      Full Text | pdf link PDF
    • Imatinib Treatment for Locally Advanced or Metastatic Dermatofibrosarcoma Protuberans: A Systematic Review
      JAMA Dermatology
      Review
      January 2, 2019

      This systematic review evaluates the use of imatinib to treat locally advanced or metastatic dermatofibrosarcoma protuberans.

      Oncology Dermatology Skin Cancer Sarcomas
      Full Text | pdf link PDF
    • Pricing a Year of Progression-Free Survival: When Is the Cost of Cancer Drugs Unreasonable?
      JAMA Dermatology
      Opinion
      January 1, 2019
      Oncology Pharmacoeconomics Health Care Economics, Insurance, Payment
      Full Text | pdf link PDF
    • Metastatic Calcinosis Cutis Associated With a Selective FGFR Inhibitor
      JAMA Dermatology
      Case Report
      January 1, 2019

      This case report describes metastatic calcinosis cutis associated with selective FGFR inhibitor therapy.

      Dermatology Surgical Oncology Oncology Hepatobiliary Disease Hepatobiliary Cancer
      Full Text | pdf link PDF
    • Economic Evaluation of Talimogene Laherparepvec Plus Ipilimumab Combination Therapy vs Ipilimumab Monotherapy in Patients With Advanced Unresectable Melanoma
      JAMA Dermatology
      Research
      January 1, 2019

      This economic evaluation assesses the cost-effectiveness of talimogene laherparepvec plus ipilimumab combination therapy vs ipilimumab monotherapy in patients with advanced unresectable melanoma from the perspective of public and private US payers.

      Oncology Pharmacoeconomics Skin Cancer Dermatology Melanoma
      Full Text | pdf link PDF has multimedia
    • Association of Cancer Immunotherapy With Acute Macular Neuroretinopathy and Diffuse Retinal Venulitis
      JAMA Ophthalmology
      Research
      January 1, 2019

      This case series describes 2 patients who developed ophthalmologic events after treatment with the programmed death 1 axis inhibitor, atezolizumab.

      Oncology Ophthalmology Retinal Disorders Macular Diseases
      Full Text | pdf link PDF
    1 2 3 4 5 … 37
    Next 20 Results »
    Get the latest from JAMA Network
    Sign Up
    Privacy Policy | Terms of Use

    Select Your Interests

    Customize your JAMA Network experience by selecting one or more topics from the list below.

    • Acid Base, Electrolytes, Fluids
    • Allergy
    • Allergy and Clinical Immunology
    • Anesthesiology
    • Anticoagulation
    • Art of the JAMA Network
    • Bleeding and Transfusion
    • Cardiology
    • Caring for the Critically Ill Patient
    • Challenges in Clinical Electrocardiography
    • Clinical Challenge
    • Clinical Decision Support
    • Clinical Implications of Basic Neuroscience
    • Clinical Pharmacy and Pharmacology
    • Complementary and Alternative Medicine
    • Consensus Statements
    • Critical Care Medicine
    • Dental Medicine
    • Dermatology
    • Diabetes and Endocrinology
    • Drug Development
    • Electronic Health Records
    • Emergency Medicine
    • End of Life
    • Environmental Health
    • Ethics
    • Facial Plastic Surgery
    • Foodborne Illness
    • Gastroenterology and Hepatology
    • Genetics and Genomics
    • Genomics and Precision Health
    • Geriatrics
    • Global Health
    • Guide to Statistics and Medicine
    • Guidelines
    • Hair Disorders
    • Health Care Delivery Models
    • Health Care Economics, Insurance, Payment
    • Health Care Policy
    • Health Care Quality
    • Health Care Reform
    • Health Care Safety
    • Health Care Workforce
    • Health Disparities
    • Health Informatics
    • Health Policy
    • Hematology
    • History of Medicine
    • Humanities
    • Hypertension
    • Images in Neurology
    • Imaging
    • Immunology
    • Infectious Diseases
    • Innovations in Health Care Delivery
    • JAMA Infographic
    • Law and Medicine
    • Leading Change
    • Less is More
    • Lifestyle Behaviors
    • Medical Coding
    • Medical Devices and Equipment
    • Medical Education
    • Medical Education and Training
    • Medical Journals and Publishing
    • Melanoma
    • Mobile Health and Telemedicine
    • Narrative Medicine
    • Nephrology
    • Neurology
    • Neuroscience and Psychiatry
    • Notable Notes
    • Nursing
    • Nutrition
    • Nutrition, Obesity, Exercise
    • Obesity
    • Obstetrics and Gynecology
    • Occupational Health
    • Oncology
    • Ophthalmic Images
    • Ophthalmology
    • Orthopedics
    • Otolaryngology
    • Pain Medicine
    • Pathology and Laboratory Medicine
    • Patient Care
    • Patient Information
    • Pediatrics
    • Performance Improvement
    • Performance Measures
    • Perioperative Care and Consultation
    • Pharmacoeconomics
    • Pharmacoepidemiology
    • Pharmacogenetics
    • Pharmacy and Clinical Pharmacology
    • Physical Medicine and Rehabilitation
    • Physical Therapy
    • Physician Leadership
    • Poetry
    • Population Health
    • Professional Well-being
    • Professionalism
    • Psychiatry
    • Public Health
    • Pulmonary Medicine
    • Radiology
    • Regulatory Agencies
    • Research, Methods, Statistics
    • Resuscitation
    • Rheumatology
    • Scientific Discovery and the Future of Medicine
    • Shared Decision Making and Communication
    • Sleep Medicine
    • Sports Medicine
    • Statistics and Research Methods
    • Stem Cell Transplantation
    • Substance Use and Addiction
    • Surgery
    • Surgical Innovation
    • Surgical Pearls
    • Teachable Moment
    • Technology and Finance
    • The Rational Clinical Examination
    • Tobacco and e-Cigarettes
    • Toxicology
    • Trauma and Injury
    • Treatment Adherence
    • United States Preventive Services Task Force
    • Urology
    • Users' Guide to the Medical Literature
    • Vaccination
    • Venous Thromboembolism
    • Veterans Health
    • Violence
    • Women's Health
    • Workflow and Process
    • Wound Care, Infection, Healing
    Save Preferences
    Privacy Policy | Terms of Use
    X

    JAMA Network

    Content

    Home Podcasts Featured Content
    JN Learning Store Apps Jobs Institutions Reprints & Permissions

    Subscribe

    Go

    JAMA Network

    Journals

    JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Facial Plastic Surgery JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959)

    Sites

    AMA Manual of Style Art and Images in Psychiatry Breast Cancer Screening Guidelines Colorectal Screening Guidelines Declaration of Helsinki Depression Screening Guidelines Evidence-Based Medicine: An Oral History Fishbein Fellowship Genomics and Precision Health Health Disparities Hypertension Guidelines JAMA Network Audio JAMA Network Conferences Machine Learning Med Men Medical Education Opioid Management Guidelines Peer Review Congress Research Ethics Sepsis and Septic Shock Statins and Dyslipidemia Topics and Collections

    Featured Articles

    ACS Breast Cancer Screening Guideline CDC Guideline for Prescribing Opioids CDC Guideline for Prevention of Surgical Site Infections Consensus Definitions for Sepsis and Septic Shock Global Burden of Cancer, 1990-2016 Global Burden of Disease in Children, 1990-2013 Global Burden of Hypertension, 1990-2015 Global Firearm Mortality, 1990-2016 Health Care Spending in the US and Other High-Income Countries Income and Life Expectancy in the US JNC 8 Guideline for Management of High Blood Pressure President Obama on US Health Care Reform Screening for Colorectal Cancer Screening for Depression in Adults Screening for Prostate Cancer Statins for Primary Prevention of Cardiovascular Disease The State of US Health, 1990-2016 US Burden of Cardiovascular Disease, 1990-2016 WMA Declaration of Helsinki, 7th Revision

    Blogs

    JAMA Forum Topics in Ophthalmology AMA Style Insider

    Information For

    Authors Institutions & Librarians Advertisers Subscription Agents Employers & Job Seekers Media

    JAMA Network Products

    AMA Manual of Style JAMAevidence JN Listen Peer Review Congress

    JN Learning

    CME Quizzes About CME & MOC MOC Reporting Preferences

    Help

    Subscriptions & Renewals Email Subscriptions Update Your Address Contact Us Frequently Asked Questions

    JAMA Career Center

    Physician Job Listings
    Get the latest from JAMA Network
    Sign Up
    Privacy Policy | Terms of Use
    Jama Network Logo

    © 2019 American Medical Association. All Rights Reserved.
    Terms of Use| Privacy Policy| Accessibility Statement

    Silverchair Logo
    .
    ×

    Sign in to access your subscriptions

    Sign in to your personal account
    Create a free personal account to download free article PDFs, sign up for alerts, and more

    Purchase access

    Subscribe to the journal
    Buy this article
    Rent this article

    Purchase access

    Subscribe to JN Learning for one year
    Buy this activity

    Sign in to download free article PDFs

    Sign in to access your subscriptions

    Sign in to your personal account
    Create a free personal account to download free article PDFs, sign up for alerts, and more

    Sign in to access your subscriptions

    Sign in to your personal account

    Purchase access

    Subscribe to the journal
    Buy this article
    Rent this article

    Sign in to save your search

    Sign in to your personal account
    Create a free personal account to access your subscriptions, sign up for alerts, and more

    Purchase access

    Subscribe now

    Sign in to save your search

    Sign in to your personal account
    Create a free personal account to access your subscriptions, sign up for alerts, and more

    Purchase access

    Subscribe to JN Learning for one year

    Sign in to customize your interests

    Sign in to your personal account
    Create a free personal account to download free article PDFs, sign up for alerts, customize your interests, and more
    Get free access to newly published articles

    Create a personal account or sign in to:

    • Register for email alerts with links to free full-text articles
    • Access PDFs of free articles
    • Manage your interests
    • Save searches and receive search alerts
    Privacy Policy

    Sign in to make a comment

    Sign in to your personal account
    Create a free personal account to make a comment, download free article PDFs, sign up for alerts and more
    Get free access to newly published articles

    Create a personal account or sign in to:

    • Register for email alerts with links to free full-text articles
    • Access PDFs of free articles
    • Manage your interests
    • Save searches and receive search alerts
    Privacy Policy
    Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our cookie policy | Continue