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    Intraocular Tumors

    Explore the latest in intraocular tumors, including recent advances in diagnosis and management of retinoblastoma, uveal melanoma, and more.

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    • Necrotic Eruption of an Inflammatory Melanoma
      JAMA Ophthalmology
      Case Report
      March 16, 2023

      This case report describes a vitreous eruption of a choroidal melanoma in a patient aged 64 years who presented with blurry vision.

      Dermatology Ophthalmic Images Skin Cancer Melanoma Oncology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Acute Unilateral Proptosis After Blunt Orbital Trauma in an Adolescent Patient
      JAMA Ophthalmology
      Case Report
      January 1, 2023

      A male patient aged 16 years with a recent history of blunt trauma to the periorbita presented with blurred vision, pain, and proptosis of the right eye. MRI imaging revealed an intraconal mass. What would you do next?

      Emergency Medicine Oncology Ophthalmology Orbit Soft-Tissue Tumors
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Assessment of Retinal Changes Following Intravitreal Aflibercept in 2 Patients With Von Hippel-Lindau Disease–Related Retinal Capillary Hemangioblastoma
      JAMA Ophthalmology
      Case Report
      December 1, 2022

      This case report of 2 patients describes peripheral Von Hippel-Lindau disease associated with a series of aflibercept injections.

      Dermatology Neurology Ophthalmology Retinal Disorders Pediatrics
      Full Text | pdf link PDF
    • A Pigmented Iris Lesion
      JAMA Ophthalmology
      Case Report
      December 1, 2022

      A patient in their mid-60s presented with a left iris pigmented lesion that had been present for decades and remained stable in size. What would you do next?

      Ophthalmology Clinical Challenge
      Full Text | pdf link PDF | CME & MOC is active quiz
    • A Recurrent Orbital Hemorrhage in an Older Adult
      JAMA Ophthalmology
      Case Report
      November 1, 2022

      An adult patient in their 70s presented with unilateral painless proptosis and blurred vision of the right eye that resolved with corticosteroid treatment. Magnetic resonance imaging revealed a retrobulbar hemorrhage. Six months later, the hemorrhage and proptosis recurred, with incomplete resolution despite similar treatment. What would you do?

      Melanoma Ophthalmology Orbit Clinical Challenge
      Full Text | pdf link PDF | CME & MOC is active quiz
    • A Pigmented Epiretinal Membrane in the Eighth Decade of Life
      JAMA Ophthalmology
      Case Report
      November 1, 2022

      A 75-year-old woman who presented with decreased visual acuity and metamorphopsia in the right eye was referred for further evaluation of a pigmented epiretinal membrane. She had a history of cutaneous nodular melanoma in the right arm. What would you do next?

      Dermatology Oncology Skin Cancer Retinal Disorders Clinical Challenge
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Trends in Incidence of Conjunctival Melanoma in the US
      JAMA Network Open
      Research
      October 18, 2022

      This cohort study assesses the incidence of conjunctival melanoma, associations between demographic factors, and trends over time in the US.

      Ophthalmology External Eye Disease Melanoma
      Full Text | pdf link PDF open access
    • Abemaciclib and Fulvestrant for Bilateral Choroidal Metastasis From Breast Carcinoma
      JAMA Ophthalmology
      Case Report
      October 1, 2022

      This case report discusses the follow-up of a woman with HR+/ERBB2 invasive ductal breast carcinoma metastatic to the lungs, brain, and spine.

      Breast Cancer Oncology Women's Health Ophthalmology Choroidal Disorders
      Full Text | pdf link PDF
    • Pterygium-Derived Artifact Simulating an Intraocular Tumor With Ultrawide-Field Imaging
      JAMA Ophthalmology
      Case Report
      October 1, 2022

      This case report describes an uncommon artifact of ultrawide-field imaging derived from a large pterygium, which mimicked an intraocular tumor.

      External Eye Disease Ophthalmic Imaging Ophthalmology
      Full Text | pdf link PDF
    • Predicted vs Observed Metastasis-Free Survival in Individuals With Uveal Melanoma
      JAMA Ophthalmology
      Research
      September 1, 2022

      This cohort study compares the predicted metastasis-free survival with the observed metastasis-free survival in patients and in other published studies.

      Oncology Ophthalmology Melanoma
      Full Text | pdf link PDF has multimedia
    • Retinoblastoma Especially Deadly in Children in Low-Income Countries
      JAMA
      News
      August 16, 2022
      Oncology Ophthalmology Pediatric Cancer Retinal Disorders Pediatrics
      Full Text | pdf link PDF
    • Cytology-Proven Primary Vitreoretinal Lymphoma in a Patient With Paraneoplastic Cloudy Vitelliform Submaculopathy
      JAMA Ophthalmology
      Case Report
      July 1, 2022

      This case report describes a diagnosis of primary vitreoretinal lymphoma in a man aged 52 years who presented with blurred vision in his right eye and optic disc edema, macular inflammation, and cloudy vitelliform submaculopathy.

      Macular Diseases Ophthalmology Retinal Disorders Hematology Hematologic Cancer
      Full Text | pdf link PDF
    • Orbital Rhabdomyosarcoma With Unusual Histopathology in a Young Adult
      JAMA Ophthalmology
      Case Report
      June 16, 2022

      This case report describes a diagnosis of orbital embryonal rhabdomyosarcoma in a man aged 22 years who presented with eyelid ptosis and diplopia.

      Pathology and Laboratory Medicine Ophthalmic Images External Eye Disease Ophthalmology Orbit
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Unilateral Intraocular Lens Implant Subluxation in an Adult
      JAMA Ophthalmology
      Case Report
      June 1, 2022

      A middle-aged patient with a remote history of bilateral juvenile cataracts after posterior chamber intraocular lens placement (PCIOL) presented with decreased vision in the right eye for several months. Examination was notable for a superonasal area of pigmentation with elevation of the conjunctiva and an inferotemporally subluxed PCIOL in the right eye. What would you do next?

      Cataract and Other Lens Disorders Choroidal Disorders Clinical Challenge Ophthalmology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Unilateral Yellowish Eye in a Woman With an Intraocular Mass
      JAMA Ophthalmology
      Case Report
      May 1, 2022

      A 65-year-old woman presented with a 6-week history of blurry vision, ocular pain, and subconjunctival yellow discoloration in the left eye but no symptoms in the right eye. Suspicious retinal detachment and intraocular mass were identified, raising concerns for choroidal melanoma, but no indication of ocular trauma, jaundice, or cutaneous melanoma was found. What would you do next?

      Oncology Ophthalmology Lung Cancer Clinical Challenge Choroidal Disorders
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Pineoblastoma Without Retinal Tumors in a Patient With a Mosaic Retinoblastoma Pathogenic Variant
      JAMA Ophthalmology
      Case Report
      April 1, 2022

      This case report describes a diagnosis of pineoblastoma in a child with a retinoblastoma pathogenic variant who presented with increasing head circumference and language and motor delay.

      Neuro-oncology Neurogenetics Neurology Pediatric Cancer Oncology
      Full Text | pdf link PDF
    • Resolution of a Presumed Conjunctival Papilloma After Therapeutic Treatment With the Human Papillomavirus Vaccine
      JAMA Ophthalmology
      Case Report
      April 1, 2022

      This case report evaluates the use of the human papillomavirus vaccine in treating conjunctival lesion in a woman in her 50s with HIV infection.

      Vaccination Infectious Diseases Oncology Ophthalmology External Eye Disease
      Full Text | pdf link PDF
    • Giant Conjunctival Carcinoma in an Adult Man
      JAMA Ophthalmology
      Case Report
      March 17, 2022

      This case report describes a diagnosis of giant conjunctival carcinoma in a man aged 67 years with a presentation of decreased visual acuity.

      External Eye Disease Ophthalmology Ophthalmic Images
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Bilateral Upper Eyelid Ecchymosis and Edema in a 13-Month-Old
      JAMA Ophthalmology
      Case Report
      February 1, 2022

      A 13-month-old boy was brought to the emergency department by his parents for bilateral eyelid ecchymosis and edema for 1 month, as well as a mass on the right temporal area that was persistent for the past month and a half. He had hit the right side of his head on a table 1 month before symptoms developed, but had no other recent trauma. What would you do next?

      Pediatric Cancer External Eye Disease Oncology Ophthalmology Clinical Challenge
      Full Text | pdf link PDF
    • Defining High-risk Retinoblastoma: A Multicenter Global Survey
      JAMA Ophthalmology
      Research
      January 1, 2022

      This survey study evaluates variations in the definition of high-risk histopathologic features for metastasis of retinoblastoma in different ocular oncology practices around the world.

      Oncology Pathology and Laboratory Medicine Ophthalmology Pediatrics Retinal Disorders
      Full Text | pdf link PDF free
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