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    Olfaction and Taste

    Explore the latest in olfaction and taste, including recent advances in understanding the etiologies and manifestations of disorders of smell and taste.

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    • Efficacy of Combined Visual-Olfactory Training With Patient-Preferred Scents as Treatment for Patients With COVID-19 Resultant Olfactory Loss: A Randomized Clinical Trial
      JAMA Otolaryngology–Head & Neck Surgery
      Research
      February 1, 2023

      This randomized clinical trial assesses the efficacy of bimodal visual-olfactory training and patient-preferred scents vs unimodal olfactory training and physician-assigned scents in treatment of COVID-19 olfactory loss.

      Coronavirus (COVID-19) Otolaryngology
      Full Text | pdf link PDF free
    • Assessing Efficacy Using Variations of Olfactory Training for COVID-19–Related Smell Loss—Would a Rose by Any Other Scent Smell as Strong?
      JAMA Otolaryngology–Head & Neck Surgery
      Opinion
      February 1, 2023
      Otolaryngology Coronavirus (COVID-19)
      Full Text | pdf link PDF free
    • Development and Psychometric Validation of the Olfactory Dysfunction Outcomes Rating
      JAMA Otolaryngology–Head & Neck Surgery
      Research
      December 1, 2022

      This study aims to develop and validate a concise and visually appealing smell loss–associated quality-of-life patient-reported outcome measure for olfactory dysfunction.

      Otolaryngology Coronavirus (COVID-19)
      Full Text | pdf link PDF | CME & MOC is active quiz
    • What's That ODOR? Optimizing the Assessment of Olfactory Dysfunction
      JAMA Otolaryngology–Head & Neck Surgery
      Opinion
      December 1, 2022
      Otolaryngology Coronavirus (COVID-19)
      Full Text | pdf link PDF
    • Development and Psychometric Validation of the Taste And Smell Tool for Evaluation (TASTE) Questionnaire
      JAMA Otolaryngology–Head & Neck Surgery
      Research
      December 1, 2022

      This survey study develops and validates an instrument with all relevant domains concerning chemosensory dysfunction and quality of life using modern psychometrics.

      Otolaryngology
      Full Text | pdf link PDF open access
    • Sociodemographic Characteristics and Comorbidities of Patients With Long COVID and Persistent Olfactory Dysfunction
      JAMA Network Open
      Research
      September 8, 2022

      This cross-sectional study describes the sociodemographic and clinical features of patients with long COVID who develop persistent olfactory dysfunction.

      Infectious Diseases Otolaryngology Coronavirus (COVID-19)
      Full Text | pdf link PDF | CME & MOC open access is active quiz
    • Loss of Smell Associated With Prior Head Injuries
      JAMA
      News
      September 6, 2022
      Otolaryngology Traumatic Brain Injury Neurology
      Full Text | pdf link PDF
    • Efficacy and Safety of Saline Nasal Irrigation Plus Theophylline for Treatment of COVID-19–Related Olfactory Dysfunction: The SCENT2 Phase 2 Randomized Clinical Trial
      JAMA Otolaryngology–Head & Neck Surgery
      Research
      September 1, 2022

      This randomized clinical trial evaluates the efficacy and safety of theophylline added to saline nasal irrigation compared with placebo for COVID-19–related olfactory dysfunction.

      Coronavirus (COVID-19) Otolaryngology
      Full Text | pdf link PDF | CME & MOC free is active quiz
    • Safety of High-Dose Nasal Theophylline Irrigation in the Treatment of Postviral Olfactory Dysfunction: A Dose-Escalation Study
      JAMA Otolaryngology–Head & Neck Surgery
      Research
      September 1, 2022

      This case series aims to determine the maximum tolerable dose of theophylline delivered via high-volume, low-pressure nasal saline irrigation for treatment of postviral olfactory dysfunction.

      Otolaryngology
      Full Text | pdf link PDF free
    • Strategies for Evaluating Anosmia Therapeutics in the COVID-19 Era—Coming to Our Senses
      JAMA Otolaryngology–Head & Neck Surgery
      Opinion
      September 1, 2022
      Coronavirus (COVID-19) Otolaryngology
      Full Text | pdf link PDF free
    • Two-Year Prevalence and Recovery Rate of Altered Sense of Smell or Taste in Patients With Mildly Symptomatic COVID-19
      JAMA Otolaryngology–Head & Neck Surgery
      Research
      September 1, 2022

      This cohort study estimates the 2-year prevalence and recovery rate of smell or taste dysfunction in patients with mildly symptomatic COVID-19.

      Otolaryngology Coronavirus (COVID-19)
      Full Text | pdf link PDF | CME & MOC free is active quiz
    • Associations of Prior Head Injury With Olfaction in Older Adults: Results From the Atherosclerosis Risk in Communities (ARIC) Study
      JAMA Otolaryngology–Head & Neck Surgery
      Research
      September 1, 2022

      This cohort study investigates the associations of prior head injury, number of prior head injuries, and head injury severity with subjective and psychophysical olfactory function in older adults.

      Traumatic Brain Injury Neurology Otolaryngology Geriatrics
      Full Text | pdf link PDF
    • Olfactory Dysfunction in Patients With Mild COVID-19 During Gamma, Delta, and Omicron Waves in Rio de Janeiro, Brazil
      JAMA
      Research
      August 9, 2022

      This study uses data obtained through an updated version of the Brazilian National Health System Questionnaire for COVID-19 to assess olfactory dysfunction in patients with mild COVID-19 in Rio de Janeiro, Brazil.

      Infectious Diseases Coronavirus (COVID-19) Otolaryngology Global Health
      Full Text | pdf link PDF free
    • Prospective Evaluation of Taste Function in Patients With Head and Neck Cancer Receiving Intensity-Modulated Radiotherapy
      JAMA Otolaryngology–Head & Neck Surgery
      Research
      July 1, 2022

      This cohort study evaluates the association between time course and recovery of taste dysfunction in patients with head and neck cancer receiving intensity-modulated radiotherapy.

      Otolaryngology Cancer Survivorship Head and Neck Cancer Oncology Radiation Oncology
      Full Text | pdf link PDF
    • Postmortem Assessment of Olfactory Tissue Degeneration and Microvasculopathy in Patients With COVID-19
      JAMA Neurology
      Research
      June 1, 2022

      This cohort study evaluates the association of COVID-19 infection with olfactory bulb by performing an ultrastructural and histopathological analysis of patients with COVID-19 and age- and disease severity–compatible controls.

      Coronavirus (COVID-19) Pathology and Laboratory Medicine Otolaryngology Infectious Diseases
      Full Text | pdf link PDF | CME & MOC free is active quiz has multimedia
    • Association of Olfactory Impairment With All-Cause Mortality: A Systematic Review and Meta-analysis
      JAMA Otolaryngology–Head & Neck Surgery
      Research
      May 1, 2022

      This systematic review and meta-analysis investigates the epidemiologic associations between olfactory impairment and mortality.

      Otolaryngology
      Full Text | pdf link PDF
    • Olfactory Impairment and Mortality—Is Smell Loss Deadly?
      JAMA Otolaryngology–Head & Neck Surgery
      Opinion
      May 1, 2022
      Otolaryngology Coronavirus (COVID-19)
      Full Text | pdf link PDF free
    • Assessment of Self-reported Sense of Smell, Objective Testing, and Associated Factors in Middle-aged and Older Women
      JAMA Otolaryngology–Head & Neck Surgery
      Research
      May 1, 2022

      This case-control study characterizes the self-awareness of poor olfaction in women, including its prevalence, associated factors, reporting reliability, validity against an objective test, and factors associated with validity.

      Otolaryngology Geriatrics Obesity Allergy and Clinical Immunology
      Full Text | pdf link PDF free
    • Development and Validation of a Novel At-home Smell Assessment
      JAMA Otolaryngology–Head & Neck Surgery
      Research
      March 1, 2022

      This diagnostic study develops and validates a simple screening assessment for olfactory dysfunction using common household items.

      Otolaryngology
      Full Text | pdf link PDF | CME & MOC free is active quiz
    • Growing Public Health Concern of COVID-19 Chronic Olfactory Dysfunction
      JAMA Otolaryngology–Head & Neck Surgery
      Research
      January 1, 2022

      This meta-analysis examines the scale of the public health concern of COVID-19–related chronic olfactory dysfunction.

      Coronavirus (COVID-19) Otolaryngology Public Health
      Full Text | pdf link PDF | CME & MOC free is active quiz
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