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    Pancreatic Cancer

    Explore the latest in pancreatic cancer, including advances in understanding the epidemiology, diagnosis, management, and prevention of the disease.

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    • Analysis of BRCA1 - and BRCA2 -Related Pancreatic Cancer and Survival
      JAMA Network Open
      Research
      November 27, 2023

      This cohort study compares the outcomes of patients with BRCA1 and BRCA-related pancreatic cancers using 2 large data sets.

      Oncology Cancer Genetics Cancer Epidemiology Genetics and Genomics Obstetrics and Gynecology
      Full Text | pdf link PDF open access
    • Repeatedly Malignant ST-Segment Elevation
      JAMA Internal Medicine
      Case Report
      November 20, 2023

      This case report describes a patient in their early 50s who presented with epigastric pain and jaundice and had significantly decreased heart rate after admission.

      Cardiology Emergency Medicine Gastroenterology Gastrointestinal Cancer Hepatobiliary Cancer
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Seeking the Real Benefits of Laparoscopic Pancreaticoduodenectomy for Pancreatic Ductal Adenocarcinoma
      JAMA Surgery
      Opinion
      October 25, 2023
      Minimally Invasive Surgery Oncology Surgery Surgical Oncology Pancreatic Surgery
      Full Text | pdf link PDF
    • Short-Term Outcomes Following Laparoscopic vs Open Pancreaticoduodenectomy in Patients With Pancreatic Ductal Adenocarcinoma: A Randomized Clinical Trial
      JAMA Surgery
      Research
      October 25, 2023

      This randomized clinical trial compares short-term outcomes among patients undergoing laparoscopic vs open pancreaticoduodenectomy for pancreatic ductal adenocarcinoma.

      Oncology Surgery Surgical Oncology Minimally Invasive Surgery Gastroenterology and Hepatology
      Full Text | pdf link PDF
    • Long-Term Outcomes and Risk of Pancreatic Cancer in Intraductal Papillary Mucinous Neoplasms
      JAMA Network Open
      Research
      October 17, 2023

      This cohort study investigates the prevalence of intraductal papillary mucinous neoplasms, their association with pancreatic cancer risk, and proportion with malignant transformation.

      Gastroenterology and Hepatology Cancer Epidemiology Radiology Cancer Screening, Prevention, Control Oncology
      Full Text | pdf link PDF open access
    • IPMNs of the Pancreas: More Epidemiologically Than Clinically Relevant
      JAMA Network Open
      Opinion
      October 17, 2023
      Gastroenterology and Hepatology Gastroenterology Gastrointestinal Cancer Oncology Pancreatic Disease
      Full Text | pdf link PDF open access
    • Prediction Model for Early-Stage Pancreatic Cancer Using Routinely Measured Blood Biomarkers
      JAMA Network Open
      Research
      August 28, 2023

      This multicenter diagnostic study assessed a prediction model that uses readily available blood biomarkers to possibly distinguish early-stage pancreatic cancer from benign periampullary diseases.

      Oncology Pancreatic Disease Surgery Surgical Oncology Gastroenterology and Hepatology
      Full Text | pdf link PDF open access
    • Risk of Syndrome-Associated Cancers Among First-Degree Relatives of Patients With Pancreatic Ductal Adenocarcinoma With Pathogenic or Likely Pathogenic Germline Variants
      JAMA Oncology
      Research
      July 1, 2023

      This case series assesses the gene-specific risk estimates of development of pancreatic ductal adenocarcinoma (PDAC) and extra-PDAC among first-degree relatives of patients with PDAC who carry pathogenic or likely pathogenic germline variants in cancer syndrome–associated genes.

      Cancer Genetics Gynecologic Cancer Gynecology Obstetrics and Gynecology Gastroenterology and Hepatology
      Full Text | pdf link PDF
    • Informing a Rational Approach to Antimicrobial Prophylaxis in Open Pancreatoduodenectomy
      JAMA
      Opinion
      May 9, 2023
      Gastroenterology Gastrointestinal Cancer Gastrointestinal Surgery Infectious Diseases Oncology
      Full Text | pdf link PDF
    • Piperacillin-Tazobactam Compared With Cefoxitin as Antimicrobial Prophylaxis for Pancreatoduodenectomy: A Randomized Clinical Trial
      JAMA
      Research
      May 9, 2023

      This phase 3 randomized clinical trial examines the effect of broad-spectrum perioperative antimicrobial prophylaxis on postoperative surgical site infection incidence compared with standard care antibiotics (cefoxitin).

      Gastroenterology Gastrointestinal Cancer Oncology Surgical Oncology Perioperative Care and Consultation
      Full Text | pdf link PDF free
    • Evaluation of Survival Following Surgical Resection for Small Nonfunctional Pancreatic Neuroendocrine Tumors
      JAMA Network Open
      Research
      March 28, 2023

      This cohort study evaluates the association between surgical resection and survival for patients with small, localized nonfunctional pancreatic neuroendocrine tumors.

      Surgery Surgical Oncology Endocrine Cancer Gastroenterology and Hepatology Gastroenterology
      Full Text | pdf link PDF open access
    • Adjuvant Therapy for Pancreatic Adenocarcinoma—Leaving No Rock Unturned
      JAMA Oncology
      Opinion
      March 1, 2023
      Gastroenterology Gastrointestinal Cancer Oncology Pancreatic Disease Surgery
      Full Text | pdf link PDF
    • Calling Out Disparities in Pancreatic Cancer Care
      JAMA Surgery
      Opinion
      March 1, 2023
      Oncology Pancreatic Disease Gastroenterology and Hepatology Health Inequities Equity, Diversity, and Inclusion
      Full Text | pdf link PDF
    • Socioeconomic and Geographic Disparities in the Referral and Treatment of Pancreatic Cancer at High-Volume Centers
      JAMA Surgery
      Research
      March 1, 2023

      This study attempts to evaluate how referral, treatment, and outcomes for patients with pancreatic adenocarcinoma vary by socioeconomic status and geography.

      Gastroenterology Gastrointestinal Cancer Health Disparities Oncology Surgery
      Full Text | pdf link PDF free
    • Association of Adjuvant Chemotherapy in Patients With Resected Pancreatic Adenocarcinoma After Multiagent Neoadjuvant Chemotherapy
      JAMA Oncology
      Research
      March 1, 2023

      This cohort study of data from the National Cancer Database on patients with pancreatic adenocarcinoma who received neoadjuvant chemotherapy compares overall survival between those who received adjuvant chemotherapy and those who did not.

      Oncology Surgery Surgical Oncology Gastroenterology and Hepatology Pancreatic Disease
      Full Text | pdf link PDF free has multimedia
    • Effect of a MUC5AC Antibody (NPC-1C) Administered With Second-Line Gemcitabine and Nab-Paclitaxel on the Survival of Patients With Advanced Pancreatic Ductal Adenocarcinoma: A Randomized Clinical Trial
      JAMA Network Open
      Research
      January 5, 2023

      This randomized clinical trial investigates whether NPC-1C, an antibody directed against MUC5AC, might increase the efficacy of second-line gemcitabine and nab-paclitaxel in patients with advanced pancreatic ductal adenocarcinoma (PDAC).

      Oncology Genetics and Genomics Targeted and Immune Cancer Therapy Cancer Biomarkers Cancer Genetics
      Full Text | pdf link PDF open access
    • Avelumab Plus Talazoparib in Patients With BRCA1/2 - or ATM -Altered Advanced Solid Tumors: Results From JAVELIN BRCA/ATM, an Open-Label, Multicenter, Phase 2b, Tumor-Agnostic Trial
      JAMA Oncology
      Research
      January 1, 2023

      This phase 2b nonrandomized controlled trial evaluates whether the combination of avelumab and talazoparib is effective in patients with pathogenic BRCA1/2 or ATM alterations, regardless of tumor type.

      Gastroenterology Gastrointestinal Cancer Prostate Cancer Urology Urologic Cancer
      Full Text | pdf link PDF open access
    • Avelumab Plus Talazoparib in Patients With Advanced Solid Tumors: The JAVELIN PARP Medley Nonrandomized Controlled Trial
      JAMA Oncology
      Research
      January 1, 2023

      This nonrandomized controlled trial assesses responses associated with the combination of avelumab and talazoparib in patients with different tumor types and molecular subtypes.

      Breast Cancer Gastroenterology Gastrointestinal Cancer Targeted and Immune Cancer Therapy Oncology
      Full Text | pdf link PDF open access
    • Evaluation of Adjuvant Chemotherapy Survival Outcomes Among Patients With Surgically Resected Pancreatic Carcinoma With Node-Negative Disease After Neoadjuvant Therapy
      JAMA Surgery
      Research
      January 1, 2023

      This cohort study evaluates survival outcomes with adjuvant chemotherapy for patients with node-negative disease after neoadjuvant therapy and surgical resection for pancreatic cancer.

      Oncology Surgery Surgical Oncology Gastroenterology and Hepatology Pancreatic Disease
      Full Text | pdf link PDF free
    • Survival After Minimally Invasive vs Open Surgery for Pancreatic Adenocarcinoma
      JAMA Network Open
      Research
      December 22, 2022

      This comparative effectiveness study evaluates long-term survival after minimally invasive and standard open surgery with curative intent among patients with pancreatic adenocarcinoma.

      Surgery Surgical Oncology Minimally Invasive Surgery Oncology Pancreatic Disease
      Full Text | pdf link PDF open access
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