Explore the latest in pancreatic disease from The JAMA Network, including advances in diagnosis and management of pancreatitis and pancreatic cancer.
A woman in her 20s with cystic fibrosis underwent bilateral endoscopic sinus surgery and medial maxillectomy 4 months after bilateral lung transplantation; at 6-week follow-up, she presented with throat pain, and 2 weeks later, with nasal obstruction. What is your diagnosis?
This study evaluates the natural history of von Hippel–Lindau disease–associated pancreatic lesions to determine the factors associated with pancreatic neuroendocrine tumor phenotype and prognosis.
A man in his 20s with panhypopituitarism, septo-optic dysplasia, developmental delay, duodenal stricture, and a history of pancreatitis presented with a painful eruption on both lower legs. What is your diagnosis?
This JAMA Insights article explains how precision health, which uses mechanistic insights to treat individual patients based on their unique abnormalities, can treat variants causing cystic fibrosis.
This Teachable Moment examines the danger in overvaluing laboratory test results that contradict clinical findings.
This comparative effectiveness study compares the utility of upfront resection vs long-term surveillance in treatment of pancreatic branch duct intraductal papillary mucinous neoplasms with worrisome features.
This Medical Letter review summarizes the composition and dosing of commercially available pancreatic enzyme replacement products used to improve digestion in patients with exocrine pancreatic insufficiency.
This study examines the protein expression and DNA alteration for the KRAS, CDKN2A, SMAD4, and TP53 main driver genes to determine their association with patient outcomes after pancreatic cancer surgical resection.
This cohort study examines the behavior and outcomes of deficient DNA mismatch repair in patients at elevated risk for malignant neoplasms, including pancreatic ductal adenocarcinoma.
This study identifies clinical factors associated with major pathologic response in a large cohort of patients who underwent preoperative therapy and pancreatectomy for pancreatic ductal adenocarcinoma.
This population-based study evaluates SEER data on the incidence and prevalence of neuroendocrine tumors over 20 years.
A man in his 70s with history of pancreatic adenocarcinoma who had undergone a Whipple procedure 2 years prior to presentation came to the emergency department with a 1-day history of waxing and waning sharp abdominal pain radiating to his back. What is your diagnosis?
This multicenter cohort study of infants with cystic fibrosis who underwent newborn screening examines incremental weight gain, linear growth, and clinical features in the first year of life.
This study examines the feasibility of using laparoscopic total pancreatectomy with islet autotransplantation in the treatment of chronic pancreatitis.
This cohort study compares the morbidity and mortality associated with primary catheter draining vs primary relaparotomy in patients with severe pancreatic fistula.
This commentary discusses lessons learned from a trial published in JAMA that reported no difference in survival between chemoradiotherapy vs chemotherapy alone in patients with locally advanced unresectable pancreatic cancer.