Explore the latest in pancreatic disease, including advances in diagnosis and management of pancreatitis and pancreatic cancer.
A 5-year-old girl with a family history of cystic fibrosis presented with constipation, poor weight gain, and a BMI below the third percentile. Three sweat chloride tests were indeterminate, a CFTR analysis panel was negative, and whole-genome sequence analysis revealed 1 cystic fibrosis–causing mutation. What would you do next?
A 67-year-old man with type 2 diabetes, unintentional weight loss, and increasing fasting blood glucose levels showed diffuse enlargement of the pancreas with peripheral hypoenhancement but no discrete mass on CT scan and soft tissue surrounding the abdominal arteries and left ureter causing hydronephrosis. Testing showed no pancreatic malignancy, no abnormal findings on colonoscopy, and lab results showed elevated IgG4. How would you interpret the test results?
A 55-year-old man with several weeks of malaise, a 6.8-kg weight loss, a CT scan with multifocal liver masses and elevated alkaline phosphatase, ALT, and AFP levels had a heterogeneously enhancing pancreatic-tail mass on triple-phase CT. What would you do next?
This cohort study of patients in 4 European countries and the United States with resected pancreatic ductal adenocarcinoma assesses the validity of the eighth edition of the American Joint Committee on Cancer TNM staging system compared with the seventh edition.
This Special Communication discusses consensus recommendations regarding follow-up of fully resected, well-differentiated, or moderately differentiated gastroenteropancreatic neuroendocrine tumors.
This cohort study assesses the association of immunologic variables and survival in patients with resectable pancreatic ductal adenocarcinoma.
This study uses 2011-2014 ACS NSQIP data to compare perioperative outcomes for early vs delayed cholecystectomy treatment among 1937 adult patients with mild gallstone pancreatitis.
An adult patient with a medical history of systemic lupus erythematosus and cystic fibrosis was seen with painless, rapidly declining vision in both eyes of 1-month duration. Normal findings were seen on objective examinations. What would you do next?
This cohort study evaluates the changes in the amount of muscular and adipose tissue before and after neoadjuvant therapy in patients with pancreatic cancer.
This population-based study investigates the survival and causes of death in patients with pancreatic adenocarcinoma to 21 years after diagnosis.
This case-control study uses Mayo Clinic registry data to assess associations between inherited germline mutations in 21 cancer predisposition genes and risk of pancreatic cancer.
This study evaluates the use of a comprehensive screening protocol for prostate, breast, colorectal, and pancreatic cancer and skin malignant abnormalities in male BRCA carriers.
This Teachable Moment questions the value of repeat lipase level assay as a follow-up measure for patients with a diagnosis of acute pancreatitis and proposes a more effective alternative.
A man in his 20s with panhypopituitarism, septo-optic dysplasia, developmental delay, duodenal stricture, and a history of pancreatitis presented with a painful eruption on both lower legs. What is your diagnosis?
This cohort study examines recurrence outcomes in patients with fully resected gastroenteropancreatic neuroendocrine tumors.
This study investigates the incidence and prognosis of gastrinomas originating in the hepatobiliary tract in patients with Zollinger-Ellison syndrome.
This study examines the protein expression and DNA alteration for the KRAS, CDKN2A, SMAD4, and TP53 main driver genes to determine their association with patient outcomes after pancreatic cancer surgical resection.
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