Explore the latest in pancreatic disease from The JAMA Network, including advances in diagnosis and management of pancreatitis and pancreatic cancer.
This study examines the protein expression and DNA alteration for the KRAS, CDKN2A, SMAD4, and TP53 main driver genes to determine their association with patient outcomes after pancreatic cancer surgical resection.
This cohort study examines the behavior and outcomes of deficient DNA mismatch repair in patients at elevated risk for malignant neoplasms, including pancreatic ductal adenocarcinoma.
This study identifies clinical factors associated with major pathologic response in a large cohort of patients who underwent preoperative therapy and pancreatectomy for pancreatic ductal adenocarcinoma.
This study evaluates the natural history of von Hippel–Lindau disease–associated pancreatic lesions to determine the factors associated with pancreatic neuroendocrine tumor phenotype and prognosis.
This population-based study evaluates SEER data on the incidence and prevalence of neuroendocrine tumors over 20 years.
A man in his 70s with history of pancreatic adenocarcinoma who had undergone a Whipple procedure 2 years prior to presentation came to the emergency department with a 1-day history of waxing and waning sharp abdominal pain radiating to his back. What is your diagnosis?
This commentary discusses lessons learned from a trial published in JAMA that reported no difference in survival between chemoradiotherapy vs chemotherapy alone in patients with locally advanced unresectable pancreatic cancer.
This cohort study uses resected cases from the International Cancer Genome Consortium to classify pancreatic ductal adenocarcinoma according to distinct mutational processes.
This multicenter cohort study of infants with cystic fibrosis who underwent newborn screening examines incremental weight gain, linear growth, and clinical features in the first year of life.
This study examines the feasibility of using laparoscopic total pancreatectomy with islet autotransplantation in the treatment of chronic pancreatitis.
This cohort study compares the morbidity and mortality associated with primary catheter draining vs primary relaparotomy in patients with severe pancreatic fistula.
This phase 2 randomized clinical trial compares selumetinib and MK-2206 vs modified FOLFOX chemotherapy in patients with metastatic pancreatic cancer for whom gemcitabine-based therapy had failed.
This study aims to determine whether there is a minimum number of minimally invasive pancreaticoduodenectomy cases performed by a hospital that is associated with a reduced likelihood of postoperative complications.
This study examines the effectiveness of robotic pancreatoduodenectomy vs open pancreatoduodenectomy for clinically relevant pancreatic fistula occurrence and other major postoperative outcomes.