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    Pancreatic Disease

    Explore the latest in pancreatic disease, including advances in diagnosis and management of pancreatitis and pancreatic cancer.

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    • Evaluation of Survival Following Surgical Resection for Small Nonfunctional Pancreatic Neuroendocrine Tumors
      JAMA Network Open
      Research
      March 28, 2023

      This cohort study evaluates the association between surgical resection and survival for patients with small, localized nonfunctional pancreatic neuroendocrine tumors.

      Surgery Surgical Oncology Endocrine Cancer Gastroenterology and Hepatology Gastroenterology
      Full Text | pdf link PDF open access
    • Calling Out Disparities in Pancreatic Cancer Care
      JAMA Surgery
      Opinion
      March 1, 2023
      Oncology Pancreatic Cancer Gastroenterology and Hepatology Health Inequities Equity, Diversity, and Inclusion
      Full Text | pdf link PDF
    • Association of Adjuvant Chemotherapy in Patients With Resected Pancreatic Adenocarcinoma After Multiagent Neoadjuvant Chemotherapy
      JAMA Oncology
      Research
      March 1, 2023

      This cohort study of data from the National Cancer Database on patients with pancreatic adenocarcinoma who received neoadjuvant chemotherapy compares overall survival between those who received adjuvant chemotherapy and those who did not.

      Oncology Surgery Surgical Oncology Gastroenterology and Hepatology Pancreatic Cancer
      Full Text | pdf link PDF has multimedia
    • Adjuvant Therapy for Pancreatic Adenocarcinoma—Leaving No Rock Unturned
      JAMA Oncology
      Opinion
      March 1, 2023
      Gastroenterology Gastrointestinal Cancer Oncology Pancreatic Cancer Surgery
      Full Text | pdf link PDF
    • Effect of a MUC5AC Antibody (NPC-1C) Administered With Second-Line Gemcitabine and Nab-Paclitaxel on the Survival of Patients With Advanced Pancreatic Ductal Adenocarcinoma: A Randomized Clinical Trial
      JAMA Network Open
      Research
      January 5, 2023

      This randomized clinical trial investigates whether NPC-1C, an antibody directed against MUC5AC, might increase the efficacy of second-line gemcitabine and nab-paclitaxel in patients with advanced pancreatic ductal adenocarcinoma (PDAC).

      Oncology Genetics and Genomics Targeted and Immune Cancer Therapy Cancer Biomarkers Cancer Genetics
      Full Text | pdf link PDF open access
    • Contemporary Surgical Management of Pancreatic Necrosis
      JAMA Surgery
      Review
      January 1, 2023

      This narrative review describes the most common treatment strategies in the step-up approach to managing necrotizing pancreatitis, including a discussion of common complications and associated issues.

      Gastroenterology Gastroenterology and Hepatology Surgery Pancreatic Surgery Hepatobiliary Surgery
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Evaluation of Adjuvant Chemotherapy Survival Outcomes Among Patients With Surgically Resected Pancreatic Carcinoma With Node-Negative Disease After Neoadjuvant Therapy
      JAMA Surgery
      Research
      January 1, 2023

      This cohort study evaluates survival outcomes with adjuvant chemotherapy for patients with node-negative disease after neoadjuvant therapy and surgical resection for pancreatic cancer.

      Oncology Surgery Surgical Oncology Gastroenterology and Hepatology Pancreatic Cancer
      Full Text | pdf link PDF
    • Survival After Minimally Invasive vs Open Surgery for Pancreatic Adenocarcinoma
      JAMA Network Open
      Research
      December 22, 2022

      This comparative effectiveness study evaluates long-term survival after minimally invasive and standard open surgery with curative intent among patients with pancreatic adenocarcinoma.

      Surgery Surgical Oncology Minimally Invasive Surgery Oncology Pancreatic Cancer
      Full Text | pdf link PDF open access
    • Association Between Polycystic Ovary Syndrome and Risk of Pancreatic Cancer
      JAMA Oncology
      Research
      December 1, 2022

      This case-control study sought to confirm the exploratory finding of an association between polycystic ovary syndrome and risk of pancreatic cancer.

      Cancer Epidemiology Cardiovascular Risk Factors Gynecology Women's Health Obstetrics and Gynecology
      Full Text | pdf link PDF
    • Bihormonal Artificial Pancreas With Closed-Loop Glucose Control vs Current Diabetes Care After Total Pancreatectomy: A Randomized Clinical Trial
      JAMA Surgery
      Research
      October 1, 2022

      This randomized crossover clinical trial compares bihormonal artificial pancreas treatment with current diabetes care in patients with total pancreatectomy.

      Medical Devices and Equipment Diabetes Diabetes and Endocrinology Surgery
      Full Text | pdf link PDF
    • Artificial Pancreas and Expanding the Use of Total Pancreatectomy
      JAMA Surgery
      Opinion
      October 1, 2022
      Diabetes Diabetes and Endocrinology Medical Devices and Equipment Surgery Pancreatic Surgery
      Full Text | pdf link PDF
    • Real-world Associations of US Cystic Fibrosis Newborn Screening Programs With Nutritional and Pulmonary Outcomes
      JAMA Pediatrics
      Research
      October 1, 2022

      This cohort study investigates the association of newborn screening for cystic fibrosis with child outcomes up to age 10 years in the US.

      Pulmonary Medicine Infectious Diseases Adolescent Medicine Gastroenterology Gastroenterology and Hepatology
      Full Text | pdf link PDF
    • The Continued Struggle for Defining a Role for Radiotherapy in Pancreas Cancer
      JAMA Oncology
      Opinion
      September 1, 2022
      Gastroenterology Gastrointestinal Cancer Oncology Pancreatic Cancer Radiation Oncology
      Full Text | pdf link PDF
    • Evaluation of Adherence to Venous Thromboembolism Prophylaxis Guidelines Among US Adults After Pancreatic Cancer Surgery
      JAMA Surgery
      Research
      September 1, 2022

      This cohort study evaluates postoperative adherence to venous thromboembolism prophylaxis guidelines among US adults with pancreatic cancer using a national population sample drawn from Surveillance, Epidemiology, and End Results–Medicare data.

      Surgery Surgical Oncology Venous Thromboembolism Oncology Pancreatic Cancer
      Full Text | pdf link PDF
    • Comparison of Society Guidelines for the Management and Surveillance of Pancreatic Cysts: A Review
      JAMA Surgery
      Review
      August 1, 2022

      This narrative review provides an overview of the current guidelines for the surveillance and management of pancreatic cystic lesions.

      Gastroenterology Guidelines Gastroenterology and Hepatology Pancreatic Surgery Surgery
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Association of Matrix Metalloproteinase 7 Expression With Pathologic Response After Neoadjuvant Treatment in Patients With Resected Pancreatic Ductal Adenocarcinoma
      JAMA Surgery
      Research
      July 13, 2022

      This single-center prognostic study of biopsy specimens from treatment-naive patients with pancreatic ductal adenocarcinoma assesses the association of aberrant gene expression as well as expression of matrix metalloproteinase 7 with pathologic response to preresection neoadjuvant therapy.

      Genetics and Genomics Oncology Surgery Surgical Oncology Cancer Genetics
      Full Text | pdf link PDF
    • Case Study: Engineered T Cells Shrank Pancreatic Cancer Tumors
      JAMA
      News
      July 12, 2022
      Gastroenterology Gastrointestinal Cancer Targeted and Immune Cancer Therapy Oncology Pancreatic Cancer
      Full Text | pdf link PDF
    • An Unusual Case of Severe Bilateral Extraocular Muscle Enlargement
      JAMA Ophthalmology
      Case Report
      July 1, 2022

      A 47-year-old woman with a history of metastatic neuroendocrine carcinoid tumor status in remission after liver transplant was hospitalized for workup of a new pancreatic mass concerning for recurrence. Examination revealed restriction of extraocular movements in all directions of gaze, diffuse punctate epithelial erosions, and mechanical lower lid entropion secondary to severe chemosis in both eyes as well as bilateral and symmetric tendon-sparing extraocular muscle enlargement of all extraocular muscles with nodular heterogenous enhancement. What would you do next?

      Ophthalmology Clinical Challenge Oncology Surgery Surgical Oncology
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Adaptive Dynamic Therapy and Survivorship for Operable Pancreatic Cancer
      JAMA Network Open
      Research
      June 23, 2022

      This cohort study evaluates the association of dynamic therapy with oncologic outcomes among patients with surgically resected pancreatic cancer.

      Oncology Cancer Biomarkers Surgery Surgical Oncology Gastroenterology and Hepatology
      Full Text | pdf link PDF open access
    • Assessment of Clinical Response Following Atezolizumab and Bevacizumab Treatment in Patients With Neuroendocrine Tumors: A Nonrandomized Clinical Trial
      JAMA Oncology
      Research
      June 1, 2022

      This nonrandomized clinical trial evaluates the response rate to treatment with a combination of bevacizumab and atezolizumab in patients with advanced neuroendocrine tumors.

      Gastroenterology Targeted and Immune Cancer Therapy Oncology Gastroenterology and Hepatology Cancer Biomarkers
      Full Text | pdf link PDF
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