Explore the latest in Parkinson disease, including advances in understanding its epidemiology, etiology, diagnosis, and management.
This cohort study describes the efficacy and safety of internal globus pallidus deep brain stimulation in Filipino patients with severe X-linked dystonia parkinsonism and predominant dystonia.
This case-control cohort study used next-generation sequencing data to determine whether for loss of function variants in LRRK1 and LRRK2 are associated with the etiology of Parkinson disease.
This randomized clinical trial evaluates the safety and tolerability of multiple intravenous infusions of PRX002/RG7935 (anti–α-synuclein monoclonal) vs placebo in patients with idiopathic Parkinson disease.
This personal narrative shares insights gleaned after the author’s father, a patient with Parkinson disease, experiences a cervical spine fracture that mandates a complicated hospitalization.
This cross-sectional study analyzes data from the Centers for Medicare & Medicaid Services to identify both effective and ineffective dementia medication prescribing patterns as well as patient characteristics and comorbid conditions associated with dementia treatment among older Medicare beneficiaries with Parkinson disease.
This systematic review and meta-analysis investigates the dose-response association between levels of physical activity and the risk of Parkinson disease by examining data from 8 studies including more than half a million participants.
This brain bank case-control study analyzes disease-specific inclusions in the key structures of the circadian system in patients with Parkinson disease, multiple system atrophy, and progressive supranuclear palsy.
This cohort study uses 2 large administrative claims databases to examine the incidence of Parkinson disease among patients with inflammatory bowel disease and to assess whether exposure to antitumor necrosis factor therapy among these patients mitigates Parkinson disease risk.
This cohort study presents an office-based screening tool for the risk of dementia in Parkinson disease.
This review evaluates the literature for the epidemiological evidence of features of α-synucleinopathies that occur before clinical onset of disease, proposes a clinical timeline of the features, and attempts to define the different premotor and clinical phenotypes associated with α-synucleinopathies.
This population-based study investigates the cumulative association of established genetic risk factors for Parkinson disease with cognitive impairment and reexamines the association of the polygenetic risk score with motor progression and survival among patients with Parkinson disease.
This review discusses the benefits and risks to be considered in selection of deep brain stimulation of the subthalamic nucleus or globus pallidus interna in patients with Parkinson disease.
This longitudinal study examines whether the course of Parkinson disease in patients with the LRRK2 mutation differs from the course of Parkinson disease in patients without the mutation.
This population-based cross-sectional study estimates the association between pemphigus and 4 neurologic conditions using one of the largest cohorts of patients with pemphigus.
This phase 2 randomized clinical trial examines the feasibility and safety of high-intensity treadmill exercise in patients with de novo Parkinson disease who are not taking medication and whether the effect on the motor system warrants a phase 3 trial.
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