Explore the latest in sepsis, including recent consensus definitions and advances in prevention, detection, and management of the syndrome.
This cohort study compares definitive therapy with oral β-lactam antibiotics vs fluoroquinolones or trimethoprim-sulfamethoxazole after 1 to 5 days of parenteral antibiotics for Enterobacterales bacteremia from a suspected urine source.
This cross-sectional study examines changes in the rates of central catheter–associated bloodstream infections and catheter-associated urinary tract infections over time in critically ill pediatric patients.
This cohort study evaluates the independent risk factors associated with mortality of patients with COVID-19 requiring treatment in the intensive care unit in the Lombardy region of Italy.
This cohort study uses data from the Intensive Care National Audit & Research Centre Case Mix Programme database to derive and validate a parsimonious prognostic score for unplanned rehospitalizations or death in the first year after hospital discharge of adult sepsis survivors.
This cohort study examined the number and type of outpatient health visits before and after hospitalization for pediatric severe sepsis.
This Viewpoint discusses the possibility that survivors of severe COVID-19 will experience persistent symptoms similar to those of post-sepsis syndrome and reviews best practices for promoting recovery from intensive care illness, including referral to physical and occupational therapy, medication optimization, and structured exercise.
This randomized clinical trial compares the effect of combination hydrocortisone, ascorbic acid, and thiamine (the HAT or Marik protocol) vs placebo on SOFA score–measured organ injury at 72 hours in patients with septic shock.
This cohort study assesses new bloodstream infections in people who inject drugs (PWID) and are receiving treatment for infective endocarditis and investigates whether new infections and treatment settings are associated with mortality.
This case series examines the clinical conditions associated with splenic infarction of adult patients between 2010 and 2015 from computed tomographic imaging scans.
This case series describes clinical characteristics, treatment, and outcomes of 17 previously healthy SARS-CoV-2–infected children and adolescents with an inflammatory phenotype overlapping with but distinct from Kawasaki disease and toxic shock syndrome admitted to a New York City hospital in late April and early May 2020.
This case series describes the clinical and laboratory characteristics of children hospitalized in England from March to May 2020 who met criteria for pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (PIMS-TS), and compares syndrome characteristics with historical cases of Kawasaki disease (KD), KD shock syndrome, and toxic shock syndrome (TSS).
This cohort study uses medical records, death certificates, and hospital discharge data to describe health care exposures and outcomes among adult patients with sepsis and septic shock.
This cohort study assesses the current incidence, microbiology, morbidity, and mortality of early-onset sepsis among a cohort of term and preterm infants.
This cohort study evaluates whether racial/ethnic disparities in key care practices and major outcomes changed among extremely preterm infants from 2002 to 2016 at centers participating in the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.
This randomized trial compares the effects of C-reactive protein (CRP)–guided antibiotic duration (discontinuation once CRP declined by 75% of peak value) vs fixed 7- vs 14-day durations on 30-day clinical failure rate among patients with gram-negative bacteremia.
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