Explore the latest in sickle cell disease, including management of pain crises, acute chest syndrome, infection prevention, and more
An African American woman presents with a 1-day history of new floaters in her right eye and no history of sickle cell disease. What would you do next?
This randomized clinical trial examines the safety and efficacy of cannabis for pain in adults with sickle cell disease.
This survey study evaluates pain interference, quality of health care, and disease-specific self-efficacy to assess perceived barriers for seeking care among adults and adolescents with sickle cell disease..
This qualitative study evaluates transcripts of interviews with adults with sickle cell disease and caregivers of patients with sickle cell disease to assess their attitudes and decision-making regarding bone marrow transplantation.
This cross-sectional study compares disease-specific federal and foundation funding for sickle cell disease and cystic fibrosis research and assesses the factors associated with research productivity.
This phase 2 clinical trial in patients with high-risk sickle cell disease assesses the feasibility, safety, and 1-year event-free survival after myeloimmunoablative conditioning and familial haploidentical stem cell transplant.
This simulated cohort modeling study compares life expectancy, quality-adjusted life expectancy, and projected lifetime income between individuals with and without sickle cell disease.
This Viewpoint reviews the molecular basis of sickle cell disease (SCD), the history of treatments for the disease, and recent progress toward curative therapies including HSCT and gene therapy and editing, emphasizing that research and innovation needs to take into account patient priorities and perspectives given the history of research mistreatment of minority groups most affected by SCD.
This Viewpoint describes the poor state of care for children with sickle cell disease and 2 quality measures to assess efforts to improve care.
This case report describes outcomes after same-day exchange transfusion for central retinal vein occlusion associated with extensive capillary and arteriolar nonperfusion in a patient with sickle cell anemia (hemoglobin SS).
This qualitative study interviews patients with sickle cell disease and identifies their views on how the current US opioid epidemic has affected the management of chronic and acute pain related to their disease.
This nonrandomized controlled intervention study compared the effect of matched sibling donor hematopoietic stem cell transplantation (HSCT) vs standard care comprising transfusions and hydroxyurea on transcranial Doppler velocities, a measure of cerebral vasculopathy, at 1 year in children with sickle cell anemia requiring chronic transfusion.
This case report describes fluorescein angiography results of a neonate with a combination diagnosis of incontinentia pigmenti and sickle cell trait.
This meta-analysis examines whether sickle cell trait is associated with a higher risk of incident ischemic stroke among African Americans.
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