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    Sickle Cell Disease

    Explore the latest in sickle cell disease, including management of pain crises, acute chest syndrome, infection prevention, and more

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    • Examining Mental Health, Education, Employment, and Pain in Sickle Cell Disease
      JAMA Network Open
      Research
      May 18, 2023

      This cross-sectional study examines the associations of educational attainment, employment status, and mental health with pain episode frequency and severity among individuals with sickle cell disease.

      Hematology Psychiatry and Behavioral Health Pain Medicine
      Full Text | pdf link PDF open access
    • Rethinking Care Models for Young Adults With Sickle Cell Disease
      JAMA Health Forum
      Opinion
      May 12, 2023

      This Viewpoint discusses developing new sickle cell disease adult care models to support specialized health care homes that are patient-focused and antiracist, rather than an approach focused mainly on financial incentives.

      Health Policy Hematology Pediatrics Adolescent Medicine
      Full Text | pdf link PDF open access
    • A Case of Acute Chest Pain After Acetazolamide to Treat Uncontrolled Increased Intraocular Pressure
      JAMA Ophthalmology
      Case Report
      April 1, 2023

      A 61-year-old man with uncontrolled increased intraocular pressure after cataract surgery was treated with acetazolamide. Three days later, he developed acute chest pain requiring emergency treatment. What would you do next?

      Glaucoma Hematology Ophthalmology Clinical Challenge Emergency Medicine
      Full Text | pdf link PDF | CME & MOC is active quiz
    • Changes in Hydroxyurea Use Among Youths Enrolled in Medicaid With Sickle Cell Anemia After 2014 Revision of Clinical Guidelines
      JAMA Network Open
      Research
      March 24, 2023

      This cross-sectional study investigates changes in the use of hydroxyurea among youths insured by Medicaid with sickle cell anemia after the 2014 revision of clinical guidelines.

      Hematology Health Care Quality Health Policy Pediatrics Adolescent Medicine
      Full Text | pdf link PDF open access
    • Sickle Cell Disease Gene Therapy Trial Paused
      JAMA
      News
      February 7, 2023
      Genetics and Genomics Drug Development Hematology
      Full Text | pdf link PDF
    • Severe Maternal Morbidity and Mortality in Sickle Cell Disease in the National Inpatient Sample, 2012-2018
      JAMA Network Open
      Research
      February 2, 2023

      This cross-sectional study of deliveries in US hospitals examines pregnancy outcomes for people with sickle cell disease (SCD) and compares adverse outcomes with Black and Non-Black populations without SCD.

      Hematology Health Disparities Health Policy Health Inequities Obstetrics and Gynecology
      Full Text | pdf link PDF open access
    • Comparisons of Severe Maternal Morbidity and Other Adverse Pregnancy Outcomes in Pregnant People With Sickle Cell Disease vs Anemia
      JAMA Network Open
      Research
      February 2, 2023

      This cross-sectional study compares rates and odds of severe maternal morbidity and other adverse pregnancy outcomes among Black pregnant individuals with sickle cell disease vs anemia.

      Hematology Bleeding and Transfusion Health Policy Health Inequities Equity, Diversity, and Inclusion
      Full Text | pdf link PDF open access
    • Gene Therapy for Sickle Cell Disease, β-Thalassemia Enters Regulatory Reviews
      JAMA
      News
      November 8, 2022
      Hematology Regulatory Agencies Genetics and Genomics
      Full Text | pdf link PDF
    • Too Few Children, Teens with Sickle Cell Anemia Receive Screening, Medication to Prevent Serious Complications
      JAMA Health Forum
      News
      November 1, 2022
      Health Policy Hematology Pediatrics Adolescent Medicine
      Full Text | pdf link PDF open access
    • Children With Sickle Cell Anemia Not Receiving Recommended Care
      JAMA
      News
      October 25, 2022
      Adolescent Medicine Hematology Neurology Stroke Pediatrics
      Full Text | pdf link PDF
    • Incidence of Acute Chest Syndrome in Children With Sickle Cell Disease Following Implementation of the 13-Valent Pneumococcal Conjugate Vaccine in France
      JAMA Network Open
      Research
      August 2, 2022

      This cohort study of children with sickle cell disease (SCD) in a French hospital system examines the association of 13-valent pneumococcal conjugate vaccine implementation with incidence of acute chest syndrome (ACS).

      Infectious Diseases Vaccination Pediatrics Hematology Public Health
      Full Text | pdf link PDF open access
    • Sickle Cell Trait Associated With Kidney Failure and COVID-19 Death
      JAMA
      News
      August 2, 2022
      Acute Kidney Injury Coronavirus (COVID-19) Nephrology Hematology
      Full Text | pdf link PDF free
    • Association of Kidney Comorbidities and Acute Kidney Failure With Unfavorable Outcomes After COVID-19 in Individuals With the Sickle Cell Trait
      JAMA Internal Medicine
      Research
      August 1, 2022

      This genetic association study assesses the association of sickle cell trait with prepandemic health conditions in Million Veteran Program participants and assesses the severity and sequelae of COVID-19.

      Coronavirus (COVID-19) Nephrology Hematology Acute Kidney Injury
      Full Text | pdf link PDF | CME & MOC free is active quiz
    • Sickle Cell Disease: A Review
      JAMA
      Review
      July 5, 2022

      This Review summarizes the pathophysiology and diagnosis for sickle cell disease (SCD), management for SCD and its related complications, and prognosis for patients with SCD.

      Hematology Pediatrics Stroke Cerebrovascular Infarction Neurology
      Full Text | pdf link PDF | CME & MOC is active quiz has multimedia
    • Evaluation of Stillbirth Among Pregnant People With Sickle Cell Trait
      JAMA Network Open
      Research
      November 24, 2021

      This cohort study investigates the association between sickle cell trait and risk of stillbirth in pregnant people.

      Health Informatics Obstetrics and Gynecology Genetics and Genomics Oncology Pregnancy
      Full Text | pdf link PDF open access
    • Improving Outcomes for Patients With Sickle Cell Disease in the United States: Making the Case for More Resources, Surveillance, and Longitudinal Data
      JAMA Health Forum
      Research
      October 29, 2021

      This review discusses how systematic data collection for sickle cell disease through a longitudinal clinical registry and a national surveillance program can improve resource use and patient outcomes and provide an equitable foundation for care.

      Health Policy Hematology
      Full Text | pdf link PDF open access
    • Hydroxyurea Use After Transitions of Care Among Young Adults With Sickle Cell Disease and Tennessee Medicaid Insurance
      JAMA Network Open
      Research
      October 13, 2021

      This cohort study examines whether hydroxyurea use changes in young adults with sickle cell disease who are transitioning from pediatric to adult health care.

      Hematology Pediatrics Adolescent Medicine
      Full Text | pdf link PDF open access
    • Prescription Drug Monitoring Program Mandates and Opioids Dispensed Following Emergency Department Encounters for Patients With Sickle Cell Disease or Cancer With Bone Metastasis
      JAMA
      Research
      July 20, 2021

      This study examines the association between prescription drug monitoring program mandates and changes in opioids dispensed to patients with sickle cell disease or cancer with bone metastasis who presented to the emergency department in 29 US states.

      Law and Medicine Oncology Substance Use and Addiction Medicine Opioids Hematology
      Full Text | pdf link PDF free
    • Gene Therapy for Sickle Cell Disease—A Debt to Be Paid
      JAMA Pediatrics
      Opinion
      June 1, 2021
      Genetics and Genomics Health Care Economics, Insurance, Payment Health Policy Hematology
      Full Text | pdf link PDF
    • A Budget Impact Analysis of Gene Therapy for Sickle Cell Disease: The Medicaid Perspective
      JAMA Pediatrics
      Research
      June 1, 2021

      This economic evaluation estimates the budget impact and affordability of a gene therapy for severe sickle cell disease from the perspective of US Medicaid programs with the highest prevalence of sickle cell disease while exploring the impact of an annuity payment model.

      Health Care Economics, Insurance, Payment Health Policy Genetics and Genomics Hematology
      Full Text | pdf link PDF free
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