Explore the latest in sickle cell disease, including management of pain crises, acute chest syndrome, infection prevention, and more
This Viewpoint reviews the molecular basis of sickle cell disease (SCD), the history of treatments for the disease, and recent progress toward curative therapies including HSCT and gene therapy and editing, emphasizing that research and innovation needs to take into account patient priorities and perspectives given the history of research mistreatment of minority groups most affected by SCD.
This Viewpoint describes the poor state of care for children with sickle cell disease and 2 quality measures to assess efforts to improve care.
This case report describes outcomes after same-day exchange transfusion for central retinal vein occlusion associated with extensive capillary and arteriolar nonperfusion in a patient with sickle cell anemia (hemoglobin SS).
This qualitative study interviews patients with sickle cell disease and identifies their views on how the current US opioid epidemic has affected the management of chronic and acute pain related to their disease.
This nonrandomized controlled intervention study compared the effect of matched sibling donor hematopoietic stem cell transplantation (HSCT) vs standard care comprising transfusions and hydroxyurea on transcranial Doppler velocities, a measure of cerebral vasculopathy, at 1 year in children with sickle cell anemia requiring chronic transfusion.
This case report describes fluorescein angiography results of a neonate with a combination diagnosis of incontinentia pigmenti and sickle cell trait.
This cohort study compares readmission rates in children with sickle cell disease and acute chest syndrome who receive guideline-adherent vs other antibiotic therapies.
This randomized clinical trial compares the incidence and time to onset of grade 2 or higher hand-foot syndrome in patients receiving pyridoxine vs placebo and identifies biomarkers predictive of hand-foot syndrome.
This case series assesses the visual function of 3 patients with sickle cell disease and temporal macular atrophy but with no visual symptoms.
This study of 2 population cohorts of African Americans compares hemoglobin A1c values among those with vs without sickle cell trait to determine whether the trait interferes with identification of prediabetes or diabetes.
This cross-sectional study assesses the feasibility of using administrative claims data to identify receipt of transcranial Doppler screening among children and adolescents with sickle cell anemia.
This case report describes a man in his 30s with a history of sickle cell disease and tonic-clonic seizures.
This randomized trial determines if longer-storage RBCs are inferior to shorter-storage RBCs for tissue oxygenation as measured by reduction in blood lactate levels and cerebral tissue oxygen saturation among children with severe anemia.
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