Explore the latest in research, methods, and statistics, including topics in clinical research infrastructure, design, conduct, and analysis.
This quality improvement study characterizes surgical oncology trials, analyzes growth, identifies associations with early discontinuation or results reporting, and evaluates proportions of trials involving each neoplasm site.
This systematic review reassesses representation since 2010-2015 of racial minority groups and women in randomized clinical trials published from 2015-2020 pertaining to dermatologic conditions that are well-studied, common, and affect patients within varied demographic categories.
This cohort study examines the translatability of findings from studies on artificial intelligence funded by the National Institutes of Health (NIH).
This cross-sectional study examines the prevalence of restricted choice of treatment in control groups among physicians and investigators conducting oncology randomized clinical trials (RCTs).
This survey study examined the views of dermatologists, rheumatologists, and patients with psoriatic disease on strategies to address the risk of cardiovascular disease.
This JAMA Guide to Statistics and Methods discusses cardinality matching, a method for finding the largest possible number of matched pairs in an observational data set, with the goal of balanced and representative samples of study participants between groups.
This randomized clinical trial evaluates the rate of in-stent restenosis and the risk of stroke recurrence after the placement of a drug-eluting stent vs standard bare-metal stent among patients with symptomatic high-grade intracranial atherosclerotic stenosis.
This Genomics and Precision Health article explores the concept of phenome-wide association studies, which use a data set to find phenotypic associations with genetic variations.
This Users’ Guide to the Medical Literature describes the fundamental concepts of platform trials and master protocols and reviews issues in the conduct and interpretation of these studies.
This qualitative study surveys otolaryngologists and radiation oncologists regarding their opinions on deintensification of surveillance in patients with diagnosed head and neck cancer.
This systematic review and meta-analysis assesses quality of life measures among patients with single-sided sensorineural deafness who received a unilateral bone conduction device.
This systematic review and meta-analysis evaluates recent evidence on the effect of hyperbaric oxygen therapy on hearing outcomes in patients with sudden sensorineural hearing loss to determine if this treatment should be part of a combination regimen.
This post hoc secondary analysis of a randomized clinical trial assesses whether routinely collected health data or streamlined mail-based follow-up data without adjudication are sufficiently accurate and complete to be the sole source of estimates of serious vascular events in patients with diabetes.
This systematic review assesses the ability of the flexible parametric cure model to determine whether immune checkpoint inhibitors are associated with an increased probability of being a long-term responder and improved progression-free survival in non–long-term responders.
This cohort study investigates the association of stage shift with population mortality among patients diagnosed with non–small cell lung cancer between 2006 and 2016.
This Viewpoint considers current challenges to developing patient-oriented researchers and offers strategies to support patient-oriented researchers at key career stages.
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