Explore the latest in gastric cancer, including advances in understanding the epidemiology, diagnosis, management, and prevention of the disease.
This cohort study assesses the association between CDH1 variant pathogenicity or family history of cancer and signet ring cell cancer and describes outcomes of minimally invasive and open total gastrectomy.
This case report details off-label treatment of a patient’s gastric adenocarcinoma with erdafitinab.
This randomized clinical trial compares the safety of laparoscopic total gastrectomy vs conventional open total gastrectomy in patients with clinical stage I gastric cancer.
This phase 3, randomized, controlled, partially blinded interventional study evaluates the antitumor activity of pembrolizumab, pembrolizumab plus chemotherapy, or chemotherapy alone in patients with untreated, advanced gastric/gastroesophageal junction cancer with PD-L1 combined positive score ≥1.
This randomized clinical trial evaluates the efficacy and safety of ursodeoxycholic acid (UDCA) in preventing gallstone formation after gastrectomy in patients with gastric cancer.
This phase 2 nonrandomized clinical trial evaluates the clinical activity and safety of the FOLFIRINOX regimen (leucovorin, fluorouracil, irinotecan, and oxaliplatin) as first-line treatment for patients with advanced gastroesophageal adenocarcinoma.
This study evaluates the diagnostic value of circulating exosomal gastric cancer–associated long noncoding RNA1 for early detection and monitoring progression of gastric cancer.
This secondary analysis of a randomized clinical trial evaluates how lifestyle factors, including smoking, alcohol intake, and diet, may change the risk of gastric cancer (GC) incidence and mortality and whether the effects of vitamin and garlic supplementation on GC are associated with major lifestyle factors.
This case series describes intratumoral spatial heterogeneity of tumor cell populations and investigates its association with survival among patients with nonmetastatic gastroesophageal adenocarcinoma.
This randomized clinical trial investigates the safety and efficacy of using indocyanine green near-infrared tracer-guided imaging during laparoscopic D2 lymphadenectomy in patients with gastric cancer.
This phase 2 trial evaluates the coprimary end points of margin-negative (R0) resection rates and pathologic response grades of gFOLFIRINOX (fluorouracil, leucovorin, oxaliplatin, and UGT1A1 genotype-directed irinotecan) therapy among patients with locally advanced gastroesophageal adenocarcinoma.
This subgroup analysis of a randomized clinical trial compares trifluridine/tipiracil treatment with placebo for progression-free and overall survival among patients with previously treated metastatic gastric or gastroesophageal junction cancer who had or had not undergone gastrectomy.
This randomized clinical trial examines the safety and advantages of laparoscopy-assisted distal gastrectomy over the traditional open gastrectomy and following chemotherapy for adults with gastric adenocarcinoma.
This review of data from 75 families with a CDH1 pathologic variant compares estimates of the lifetime risk of gastric cancer in the families found to have a CDH1 pathologic variant through clinical ascertainment with those ascertained through multigene panel testing.
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