Explore the latest in toxicology from The JAMA Network, including the epidemiology, health effects, and management of environmental toxic exposures.
This Viewpoint reviews the potential health risks associated with fracking in the United States, including effects on air quality and consequences of exposure to fracking fluids, and proposes policy and public health safeguards to prevent harms.
A 15-year-old boy presented to a hospital with pain and purpura of his left thigh after an intramuscular injection. What is your diagnosis?
This clinical trial examines whether adaptive radiation therapy can target high-dose radiation to the 18F-fludeoxyglucose (FDG)-avid tumor on midtreatment FDG–positron emission tomography with computed tomography to improve local tumor control of locally advanced non–small-cell lung cancer.
This multicenter clinical study evaluates outcomes in different age groups among older patients with de novo acute myeloid leukemia who received HLA-mismatched microtransplant.
This study characterizes purpuric skin eruptions caused by epidermal growth factor receptor inhibitors.
This Viewpoint questions the use of anthracyclines in the treatment of gastroesophageal cancers.
This study uses Medicaid data to compare prescription opioid use, duration of opioid use, and rates of medication-assisted treatment (buprenorphine, methadone, or naltrexone) among enrollees before and after an overdose event.
This study addressed toxic effects and time to treatment failure in patients with melanoma treated with nivolumab plus ipilimumab.
This open-label, single-group assignment phase 2 study reports 5-year results evaluating concurrent chemotherapy and high-dose proton beam radiotherapy to treat unresectable stage III non–small cell lung cancer.
This systematic review compares outcomes and toxic effects between thoracic radiation with either cisplatin-etoposide or carboplatin-paclitaxel for patients with stage III non–small-cell lung cancer.
This randomized, double-blind, placebo-controlled clinical trial evaluates the efficacy and safety of extended-release ADS-5102 (amantadine) 274-mg capsules for treatment of levodopa-induced dyskinesia in patients with Parkinson disease.
This Medical Letter review summarizes management of anaphylaxis and of insect bites and stings, including information about commercially available epinephrine auto-injectors for use by at-risk patients.
This case series study characterizes the immunohistochemical phenotype of the infiltrate in histiocytoid Sweet syndrome and evaluates whether this variant of Sweet syndrome is more frequently associated with hematologic malignancies than classic Sweet syndrome.
This Viewpoint provides recommendations to prevent and reduce prenatal and childhood lead exposure and lead toxicity in children in the United States.
This review examines the incidence, clinical presentations, and mechanisms of cardiovascular complications in patients with multiple myeloma.