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    Toxicology

    Explore the latest in toxicology, including the epidemiology, health effects, and management of environmental toxic exposures.

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    • Association of Household Opioid Availability With Opioid Overdose
      JAMA Network Open
      Research
      March 17, 2023

      This cohort study examines the risk for opioid overdose associated with the presence of opioids within the household.

      Substance Use and Addiction Medicine Opioids Public Health
      Full Text | pdf link PDF open access
    • Association of Implementation of Postoverdose Outreach Programs With Subsequent Opioid Overdose Deaths Among Massachusetts Municipalities
      JAMA Psychiatry
      Research
      March 15, 2023

      This time-series analysis assesses the association of implementation of postoverdose outreach programs with opioid fatality rates in Massachusetts municipalities with high numbers of opioid-related medical emergency services responses.

      Substance Use and Addiction Medicine Opioids
      Full Text | pdf link PDF has multimedia
    • Universal Precautions for People at Risk of Opioid Overdose in North America
      JAMA Internal Medicine
      Opinion
      March 13, 2023

      This viewpoint discusses and suggests clinical interventions to be implemented by clinicians and health systems in North America to reduce opioid overdose deaths among at-risk patients.

      Substance Use and Addiction Medicine Opioids Public Health
      Full Text | pdf link PDF
    • Mortality Trends Among Adults Experiencing Homelessness in Boston, Massachusetts From 2003 to 2018
      JAMA Internal Medicine
      Research
      March 13, 2023

      This cohort study involves assessing causes of death among people experiencing homelessness in Boston from 2003 to 2018.

      Health Disparities Substance Use and Addiction Medicine Opioids Equity, Diversity, and Inclusion Public Health
      Full Text | pdf link PDF
    • What Is Lead Poisoning?
      JAMA
      Patient Information
      March 10, 2023

      This JAMA Patient Page describes lead poisoning, its health effects, diagnosis, treatment, and prevention measures.

      Patient Information JAMA Patient Information Environmental Health
      Full Text | pdf link PDF free
    • States’ Methods for Capturing and Reporting Local Responses to Suspected Nonfatal Drug Overdoses
      JAMA
      Research
      March 7, 2023

      This study examines the available data used to surveil state-level drug overdoses and characterizes them based on their timeliness, drug involvement, and specification of nonfatal outcomes.

      Substance Use and Addiction Medicine Opioids Public Health Health Policy Health Informatics
      Full Text | pdf link PDF
    • Association of FDA Mandate Limiting Acetaminophen (Paracetamol) in Prescription Combination Opioid Products and Subsequent Hospitalizations and Acute Liver Failure
      JAMA
      Research
      March 7, 2023

      This interrupted time-series analysis uses data from the National Inpatient Sample and the Acute Liver Failure Study Group to assess the odds of hospitalization and the proportion of acute liver failure cases with acetaminophen and opioid toxicity prior to and after the US Food and Drug Administration mandate to limit acetaminophen (paracetamol) to 325 mg/tablet in combination acetaminophen and opioid medications.

      Law and Medicine Substance Use and Addiction Medicine Opioids Public Health Health Policy
      Full Text | pdf link PDF has multimedia
    • Moving the Needle to Reduce Acetaminophen (Paracetamol) Hepatotoxicity
      JAMA
      Opinion
      March 7, 2023
      Public Health Health Policy Gastroenterology and Hepatology Hepatobiliary Disease Adverse Drug Events
      Full Text | pdf link PDF has multimedia
    • Years of Life Lost to Drug Overdose Among Black Female Individuals in the US, 2015-2021
      JAMA Psychiatry
      Research
      March 1, 2023

      This cross-sectional study calculates years of life lost to drug overdose in non-Hispanic Black female individuals and describes the changes in years of life lost that have occurred during the current overdose crisis.

      Full Text | pdf link PDF
    • Assessment of Alcohol Exposure From Alcohol-Based Disinfectants Among Premature Infants in Neonatal Incubators in Japan
      JAMA Network Open
      Research
      February 24, 2023

      This quality improvement study examines blood alcohol concentrations in premature infants and evaporated alcohol concentrations within neonatal incubators before and after implementation of a practice limiting exposure of the infants to alcohol disinfectants.

      Pediatrics Neonatology
      Full Text | pdf link PDF open access
    • Identification of Bradycardia Following Remdesivir Administration Through the US Food and Drug Administration American College of Medical Toxicology COVID-19 Toxic Pharmacovigilance Project
      JAMA Network Open
      Research
      February 14, 2023

      This cohort study examines the incidence of bradycardia occurring during or after administration of remdesivir in patients with COVID-19 through the US Food and Drug Administration American College of Medical Toxicology COVID-19 Toxic (FACT) Pharmacovigilance Project.

      Public Health Rhythm Disorders Pharmacy and Clinical Pharmacology Cardiology Adverse Drug Events
      Full Text | pdf link PDF open access
    • Changes in Pregnancy-Associated Deaths in the US During the COVID-19 Pandemic in 2020
      JAMA Network Open
      Research
      February 1, 2023

      This cross-sectional study assesses changes in pregnancy-associated mortality from drug overdose, homicide, suicide, and other causes in the US from 2018 through 2020.

      Obstetrics and Gynecology Pregnancy Obstetrics Women's Health Coronavirus (COVID-19)
      Full Text | pdf link PDF open access
    • Prevalence of Alcohol in Unintentional Opioid Overdose Deaths, 2017-2020
      JAMA Network Open
      Research
      January 24, 2023

      This cross-sectional study investigates the prevalence of alcohol in unintentional opioid overdose deaths in Illinois from 2017 through 2020.

      Substance Use and Addiction Medicine Alcohol Opioids
      Full Text | pdf link PDF open access
    • Fentanyl Drives Startling Increases in Adolescent Overdose Deaths
      JAMA
      News
      January 24, 2023
      Public Health Substance Use and Addiction Medicine Opioids Adolescent Medicine Pediatrics
      Full Text | pdf link PDF
    • US Life Expectancy in 2021 Lowest Since 1996
      JAMA
      News
      January 24, 2023
      Oncology Cancer Epidemiology Opioids Substance Use and Addiction Medicine Coronavirus (COVID-19)
      Full Text | pdf link PDF
    • Telemedicine Use and Quality of Opioid Use Disorder Treatment in the US During the COVID-19 Pandemic
      JAMA Network Open
      Research
      January 24, 2023

      This cohort study assesses the level of telehealth implementation and its outcomes among office-based clinicians who provide outpatient opioid use disorder care.

      Substance Use and Addiction Medicine Opioids Health Policy Health Care Delivery Models Mobile Health and Telemedicine
      Full Text | pdf link PDF open access
    • Trends and Characteristics of Buprenorphine-Involved Overdose Deaths Prior to and During the COVID-19 Pandemic
      JAMA Network Open
      Research
      January 20, 2023

      This cross-sectional study assesses whether buprenorphine-involved overdose deaths changed after implementing more flexible prescription policies during the COVID-19 pandemic and highlights characteristics and circumstances of these deaths

      Public Health Substance Use and Addiction Medicine Opioids Coronavirus (COVID-19)
      Full Text | pdf link PDF open access
    • Pediatric Hospitalizations for Unintentional Cannabis Poisonings and All-Cause Poisonings Associated With Edible Cannabis Product Legalization and Sales in Canada
      JAMA Health Forum
      Research
      January 13, 2023

      This cross-sectional study uses population data to evaluate the association of pediatric hospitalizations for cannabis poisoning with legalization of edible cannabis products in Canada.

      Health Policy Emergency Medicine Law and Medicine Substance Use and Addiction Medicine Pediatrics
      Full Text | pdf link PDF open access
    • Fentanyl Overdose
      JAMA
      Patient Information
      January 10, 2023

      This JAMA Patient Page describes fentanyl and illicit fentanyl analogues, and the common signs and symptoms of fentanyl overdose, its treatment, and overdose prevention measures.

      Emergency Medicine Patient Information JAMA Patient Information Opioids Substance Use and Addiction Medicine
      Full Text | pdf link PDF free
    • Effect of Prescriber Notifications of Patient’s Fatal Overdose on Opioid Prescribing at 4 to 12 Months: A Randomized Clinical Trial
      JAMA Network Open
      Research
      January 6, 2023

      This randomized clinical trial evaluates the effect of prescriber notifications of a patient’s fatal overdose on opioid prescribing, including decreases in morphine milligram equivalents, new patients taking opioids, and patients taking a high dose, at 4 to 12 months after notification.

      Health Policy Substance Use and Addiction Medicine Opioids
      Full Text | pdf link PDF open access
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