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    Diabetes

    Explore the latest in diabetes, including advances in screening, prevention, diagnosis, and treatment of the disease.

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    • Patterns of Regional Brain Atrophy and Brain Aging in Middle- and Older-Aged Adults With Type 1 Diabetes
      JAMA Network Open
      Research
      June 1, 2023

      This cohort study evaluates neuroimaging markers of brain age and Alzheimer disease–like atrophy in participants with type 1 diabetes and assesses the association between cognition and brain aging indices.

      Diabetes and Endocrinology Geriatrics Neurology Dementia and Cognitive Impairment
      Full Text | pdf link PDF open access
    • Association of Prescription Co-payment With Adherence to Glucagon-Like Peptide-1 Receptor Agonist and Sodium-Glucose Cotransporter-2 Inhibitor Therapies in Patients With Heart Failure and Diabetes
      JAMA Network Open
      Research
      June 1, 2023

      This cohort study compares rates of 1-year adherence to glucagon-like peptide-1 receptor agonist or sodium-glucose cotransporter 2 inhibitor therapies by co-payment level among US adults with type 2 diabetes and/or heart failure.

      Cardiology Clinical Pharmacy and Pharmacology Treatment Adherence Cardiovascular Risk Factors Health Care Economics, Insurance, Payment
      Full Text | pdf link PDF open access
    • Systemic Adverse Events Among Patients With Diabetes Treated With Intravitreal Anti–Vascular Endothelial Growth Factor Injections
      JAMA Ophthalmology
      Research
      June 1, 2023

      This cohort study evaluates the risks of adverse events associated with intravitreal anti–vascular endothelial growth factor injections in individuals with diabetes.

      Diabetic Retinopathy Clinical Pharmacy and Pharmacology Ophthalmology Adverse Drug Events Retinal Disorders
      Full Text | pdf link PDF
    • FDA Greenlights Automated Insulin Dosing System for Type 1 Diabetes
      JAMA
      News
      May 31, 2023
      Medical Devices and Equipment Diabetes and Endocrinology
      Full Text | pdf link PDF free
    • Assessment of Parafoveal Diabetic Macular Ischemia on Optical Coherence Tomography Angiography Images to Predict Diabetic Retinal Disease Progression and Visual Acuity Deterioration
      JAMA Ophthalmology
      Research
      May 25, 2023

      This cohort study investigates the association of the deep learning–based diabetic macular ischemia with the subsequent risk of diabetic retinopathy progression, diabetic macular edema development, and visual acuity deterioration.

      Diabetic Retinopathy Diabetes and Endocrinology Retinal Disorders Health Informatics Ophthalmic Imaging
      Full Text | pdf link PDF has multimedia
    • Temporal Changes in Obesity-Related Medication After Bariatric Surgery vs No Surgery for Obesity
      JAMA Surgery
      Research
      May 24, 2023

      This cohort study aims to clarify the long-term trajectories of lipid-lowering, cardiovascular, and antidiabetic medication in patients who have undergone bariatric surgery compared with matched patients who received no surgery for morbid obesity.

      Cardiology Dyslipidemia Cardiovascular Risk Factors Pharmacoepidemiology Clinical Pharmacy and Pharmacology
      Full Text | pdf link PDF open access
    • Benefits of Mandated Registries for Generating Real-World Outcome Data
      JAMA Surgery
      Opinion
      May 24, 2023
      Dyslipidemia Cardiology Cardiovascular Risk Factors Pharmacoepidemiology Obesity
      Full Text | pdf link PDF
    • Prediabetes and Fracture Risk Among Midlife Women in the Study of Women’s Health Across the Nation
      JAMA Network Open
      Research
      May 23, 2023

      This cohort study uses data from the Study of Women’s Health Across the Nation to evaluate whether prediabetes before the menopause transition is associated with incident fracture during and after the menopause transition.

      Diabetes and Endocrinology Orthopedics Gynecology Obstetrics and Gynecology Osteoporosis
      Full Text | pdf link PDF open access
    • Type 1 Diabetes Incidence and Risk in Children With a Diagnosis of COVID-19
      JAMA
      Research
      May 22, 2023

      This study used a population-based individual patient data set that included diagnoses of COVID-19 to determine whether there was a temporal association between COVID-19 and type 1 diabetes in children.

      Infectious Diseases Coronavirus (COVID-19) Diabetes and Endocrinology Pediatrics
      Full Text | pdf link PDF free
    • Efficacy and Safety of Oral Small Molecule Glucagon-Like Peptide 1 Receptor Agonist Danuglipron for Glycemic Control Among Patients With Type 2 Diabetes: A Randomized Clinical Trial
      JAMA Network Open
      Research
      May 22, 2023

      This randomized clinical trial investigates the efficacy, safety, and tolerability of danuglipron treatment for 16 weeks in adults with type 2 diabetes and inadequate glycemic control on diet and exercise, with or without the use of metformin.

      Diabetes and Endocrinology Pharmacy and Clinical Pharmacology Clinical Pharmacy and Pharmacology Drug Development
      Full Text | pdf link PDF open access
    • Comparative Effects of Glucose-Lowering Medications on Kidney Outcomes in Type 2 Diabetes: The GRADE Randomized Clinical Trial
      JAMA Internal Medicine
      Research
      May 22, 2023

      This randomized clinical trial evaluates kidney function with the use of medications added to metformin treatment in patients with type 2 diabetes.

      Clinical Pharmacy and Pharmacology Nephrology Diabetes and Endocrinology
      Full Text | pdf link PDF
    • Analysis of All-Cause Hospitalization and Death Among Nonhospitalized Patients With Type 2 Diabetes and SARS-CoV-2 Infection Treated With Molnupiravir or Nirmatrelvir-Ritonavir During the Omicron Wave in Hong Kong
      JAMA Network Open
      Research
      May 19, 2023

      This cohort study examines the effectiveness of molnupiravir and nirmatrelvir-ritonavir in nonhospitalized patients with type 2 diabetes and SARS-CoV-2 infection during the Omicron wave in Hong Kong.

      Pharmacy and Clinical Pharmacology Coronavirus (COVID-19) Clinical Pharmacy and Pharmacology Diabetes and Endocrinology
      Full Text | pdf link PDF open access
    • Cost-Related Insulin Rationing in US Adults Younger Than 65 Years With Diabetes
      JAMA
      Research
      May 16, 2023

      This study uses 2021 National Health Interview Survey data to examine the prevalence of insulin rationing among adults younger than 65 years in the US by demographic characteristics.

      Health Care Economics, Insurance, Payment Pharmacoeconomics Pharmacoepidemiology Diabetes and Endocrinology Health Policy
      Full Text | pdf link PDF
    • Fetal Cardiac Function at Midgestation in Women Who Subsequently Develop Gestational Diabetes
      JAMA Pediatrics
      Research
      May 15, 2023

      This study assesses cardiac morphology and function at midgestation in fetuses of mothers prior to development of gestational diabetes and compares them with those of unaffected controls.

      Cardiology Neonatology Pediatrics Women's Health Obstetrics
      Full Text | pdf link PDF
    • Topical Esmolol Hydrochloride as a Novel Treatment Modality for Diabetic Foot Ulcers: A Phase 3 Randomized Clinical Trial
      JAMA Network Open
      Research
      May 15, 2023

      This randomized clinical trial evaluates the use of topical esmolol hydrochloride combined with standard of care treatment vs standard care alone in patients with diabetic foot ulcers.

      Diabetes and Endocrinology Neuropathy Surgery Vascular Surgery
      Full Text | pdf link PDF open access
    • Rectifying Errors and an Apology for a Study of Possible Differential Effects of an Intervention Among Black and White Patients
      JAMA Network Open
      Opinion
      May 12, 2023
      Health Disparities Health Policy Health Inequities Equity, Diversity, and Inclusion Ethics
      Full Text | pdf link PDF open access
    • Estimating Changes in Medicare Part D and Commercial Insurer Insulin Spending Amid Planned State-Led Biosimilar Insulin Production in California
      JAMA Internal Medicine
      Research
      May 8, 2023

      This cross-sectional study evaluates the cost savings of state-led manufacturing and selling of biosimilar insulin.

      Clinical Pharmacy and Pharmacology Health Care Economics, Insurance, Payment Diabetes and Endocrinology Health Policy Pharmacoeconomics
      Full Text | pdf link PDF
    • Diabetes Care Barriers, Use, and Health Outcomes in Younger Adults With Type 1 and Type 2 Diabetes
      JAMA Network Open
      Research
      May 5, 2023

      This cohort study examines health, socioeconomic, structural, and other factors associated with access to and use of diabetes care in younger adults.

      Diabetes and Endocrinology Health Policy Health Care Economics, Insurance, Payment
      Full Text | pdf link PDF open access
    • Perception and Awareness of Diabetes Risk and Reported Risk-Reducing Behaviors in Adolescents
      JAMA Network Open
      Research
      May 3, 2023

      This cross-sectional study examines whether there are associations between diabetes risk perception and/or awareness and health behaviors in youth.

      Pediatrics Diabetes and Endocrinology Nutrition, Obesity, Exercise Obesity Adolescent Medicine
      Full Text | pdf link PDF open access
    • Association of Cardiac Biomarkers With Major Adverse Cardiovascular Events in High-risk Patients With Diabetes: A Secondary Analysis of the DECLARE-TIMI 58 Trial
      JAMA Cardiology
      Research
      May 1, 2023

      This secondary analysis of the DECLARE-TIMI 58 trial evaluates whether N-terminal pro–B-type natriuretic peptide and high-sensitivity cardiac troponin T levels can identify a subset of patients with type 2 diabetes at higher risk and who might benefit more from dapagliflozin with regard to atherosclerotic events.

      Acute Coronary Syndromes Ischemic Heart Disease Diabetes and Endocrinology Cardiology
      Full Text | pdf link PDF
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