Multiple sclerosis has steadily held the attention of the investigators for a number of decades, and the careful clinical study of the disease in connection with exhaustive histopathologic research has resulted in a number of theories on the basis of which the more recent histologic studies have given gratifying results.
The newer methods of staining and modifications of the older ones made it possible to differentiate more definitely the tissue elements which enter into the pathologic process and in consequence of this, these have been minutely described. However, it is evident in the conclusions drawn from the results which have been revealed that the interpretation of the tissue changes and their correlation, not only from a histopathologic standpoint, but also in connection with the reaction of certain tissue elements under abnormal conditions and the reaction of a feeble biogenetic balance in the tissue as a whole, is incomplete and the
KLINGMAN T. THE HISTOGENESIS OF MULTIPLE SCLEROSIS. Arch NeurPsych. 1919;1(1):39–NP. doi:10.1001/archneurpsyc.1919.02180010042004
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