The basis of this paper rests on the observation of six cases of multiple sclerosis. All of the six were symptomatically typical. Two were relatively early, the others were more advanced. Spasticity of both legs and bilateral Babinski sign were present in all; abdominal reflexes were uniformly absent; all, except one early case, showed pallor of the temporal half of each disk; nystagmus and intention tremor were present in all. All had complained of bladder irritability which had appeared early in each instance; incoordination of upper as well as lower extremities was present in all. Sensory symptoms were practically absent. As a discussion of symptomatology is not intended, transcript of case histories is omitted as the symptoms common to all the cases seem to furnish sufficient positive evidence, and negative blood serum and cerebrospinal serologic findings and the clinical progress, insufficient negative evidence to establish the diagnoses fairly clearly without
WOODBURY MS. A PROBABLE ETIOLOGIC FACTOR IN MULTIPLE SCLEROSIS. Arch NeurPsych. 1919;1(4):408–NP. doi:10.1001/archneurpsyc.1919.02180040025002
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