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August 1919

THE COLLOIDAL GOLD REACTION IN FOUR HUNDRED AND NINETY-EIGHT PSYCHIATRIC CASES

Arch NeurPsych. 1919;2(2):180-191. doi:10.1001/archneurpsyc.1919.02180080034004

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Abstract

The following report is an analysis of the colloidal gold reaction in 498 cases of various psychoses in which there was suspected a nervous syphilis from the clinical findings of pupillary changes, exaggerated or lost reflexes, speech defects, histories of early cardiovascular involvement or apoplexies; with miscarriages, still births, defective mental development or more frank syphilitic manifestations in the immediate relations. No case was punctured which did not show either a positive Wassermann reaction of the serum with suggestive neurological symptoms, or neurological symptoms which made dependence on a negative serum inadvisable. The colloidal gold reaction is of special interest in regard to the reliability of the test as a means of diagnosis of syphilis when all other tests are negative and as a method of differentiation between general paralysis of the insane and cerebrospinal syphilis. Lange's original method was at first used, but later the modification of Miller and

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