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The following report is an analysis of the colloidal gold reaction in 498 cases of various psychoses in which there was suspected a nervous syphilis from the clinical findings of pupillary changes, exaggerated or lost reflexes, speech defects, histories of early cardiovascular involvement or apoplexies; with miscarriages, still births, defective mental development or more frank syphilitic manifestations in the immediate relations. No case was punctured which did not show either a positive Wassermann reaction of the serum with suggestive neurological symptoms, or neurological symptoms which made dependence on a negative serum inadvisable. The colloidal gold reaction is of special interest in regard to the reliability of the test as a means of diagnosis of syphilis when all other tests are negative and as a method of differentiation between general paralysis of the insane and cerebrospinal syphilis. Lange's original method was at first used, but later the modification of Miller and
RAWLINGS E. THE COLLOIDAL GOLD REACTION IN FOUR HUNDRED AND NINETY-EIGHT PSYCHIATRIC CASES. Arch NeurPsych. 1919;2(2):180–191. doi:10.1001/archneurpsyc.1919.02180080034004
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