The pharmacologic response of the brain vessels in man is a question presenting more than ordinary difficulty to experimental study, particularly under normal, nonoperative conditions. The only work of any significance in the latter connection is that of Shepard,1 and even here the matter of specific drug effect is but incidentally dealt with—only one group, that of the nitrites, having been definitely reported. It was deemed distinctly fortunate, therefore, when the presentation of a suitable subject rendered further investigation possible.
REPORT OF CASE
The subject R. K., aged 40, a male patient at the State Psychopathic Hospital, had undergone double subtemporal decompression for the relief of increased intracranial pressure, presumably of tumor origin. The first decompression had been performed nine months, and the second, eight months prior to the initiation of this study, the patient, having by that time, fully recovered from all operative reaction. There developed residually,
RAPHAEL T, STANTON JM. THE ACTION OF CERTAIN DRUGS ON BRAIN CIRCULATION IN MAN. Arch NeurPsych. 1919;2(4):389–392. doi:10.1001/archneurpsyc.1919.02180100022003
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