Syphilis of the nervous system has been attracting considerable attention from syphilographers of late, so much so that at the present time the journals are full of reports dealing with spinal fluid findings in cases of secondary and latent syphilis, in many cases with remarkable serologic evidence of invasion of the central nervous system with or without definite neurologic signs. Many represent latent cases of paresis or cerebrospinal syphilis, in which the invasion by spirochete and alterations in the spinal fluid occur a considerable time before we have any clinical evidence of such invasion. Cases of this type are much more frequently seen in the outpatient department of general hospitals, or in the practice of a syphilographer, than they are in nerve clinics or in the outpatient department of the psychopathic hospital. As mental symptoms are usually absent, such cases are only rarely seen in the state institutions.
LOWREY LG. FURTHER OBSERVATIONS ON NEUROSYPHILIS AND THE PSYCHOSES. Arch NeurPsych. 1920;3(5):500–529. doi:10.1001/archneurpsyc.1920.02180170039003
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