Just forty years ago, in 1880, there appeared an article on myxedema in the Boston Medical and Surgical Journal by Dr. William A. Hammond. He reported the first case of the kind in America. Based on necropsies of similar cases in England, he came to the conclusion that the mental symptoms were due to the mucoid deposits throughout the brain structure and that probably the cause of the disease lay there. No mention or thought of thyroid disturbance entered. Since that time we have made some progress. Does any one doubt that today, confronting us, are states of disease in which we show the same lamentable lack of knowledge? In the same year, Dr. George M. Beard presented at the American Neurological Association a report on neurasthenia—nerve exhaustion—with remarks on treatment; Dr. Hammond presented a paper on thalamic epilepsy, and Dr. Gray a paper on the "Interconvertibility of Migraine and
TIMME W. ENDOCRINOLOGIC ASPECTS OF SOME NEUROLOGIC CONDITIONS. Arch NeurPsych. 1920;3(6):601–608. doi:10.1001/archneurpsyc.1920.02180180002001
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