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October 1920


Author Affiliations

Resident Physician, Neurological Service, Cook County Hospital CHICAGO

From the Surgical Service of Peter Bent Brigham Hospital, Boston, and from the Pathological Laboratories of Cook County and Psychopathic Hospitals, Chicago.

Arch NeurPsych. 1920;4(4):401-416. doi:10.1001/archneurpsyc.1920.02180220050004

INTRODUCTION  In 1904, Nonne1 reported a series of cases which he tried to combine into a clinical entity. This was characterized by a more or less chronic development of the picture of brain tumor, with or without localizing signs, and without discoverable etiology. The patients usually recovered, either spontaneously or after treatment with mercury and iodids. If death occurred, no adequate macroscopic or microscopic lesions could be found. Nonne went so far as to claim that in some cases no microscopic pathology was present.Nonne's publication was followed by numerous reports of similar cases in some of which the symptom-complex in question was referred to as "die Nonnesche Krankheit"2 or "das neue Kranksheitsbild."3 Prior to Nonne, a number of similar cases were reported by Quincke4 under the name of serous meningitis.It was well known that various pathologic conditions could simulate brain tumor, but the idea